Michael and Lee Bell Professor of Women's Health
Brigham and Women's Hospital
Professor of Epidemiology
Harvard School of Public Health
Brigham and Women's Hospital
Division of Preventive Medicine
900 Commonwealth Avenue East, 3rd floor
Boston, Massachusetts 02215
JoAnn E. Manson, MD, DrPH is Chief of the Division of Preventive Medicine at Brigham and Women’s Hospital and the Michael and Lee Bell Professor of Women’s Health at Harvard Medical School. She is an endocrinologist, epidemiologist, and expert in women's health and preventive medicine. She leads several major research studies addressing prevention of heart disease, diabetes, and cancer, including the VITamin D and OmegA-3 TriaL (VITAL; www.vitalstudy.org), the Women’s Health Initiative Clinical Center in Boston, the Women’s Antioxidant and Folic Acid Cardiovascular Study, the cardiovascular component of the Nurses’ Health Study, and the KEEPS center in Boston (these studies are described below).
Her primary research interests include the role of lifestyle and nutritional factors, particularly vitamin D, omega-3s, and folate, in the prevention of chronic disease, the effects of moderate-intensity vs. vigorous exercise, and the risks and benefits of estrogen therapy. Manson has received numerous awards and honors, including the “Woman in Science” Award from the American Medical Women’s Association, the American Heart Association’s Population Research Prize, the AHA's Distinguished Scientist Award, the Bernadine Healy Award for Visionary Leadership in Women's Health, election to the Institute of Medicine and the Association of American Physicians, and she recently served as president of the North American Menopause Society (NAMS). She has published more than 700 articles in the medical literature and is the author or editor of several books, including Prevention of Myocardial Infarction (1996), Clinical Trials in Heart Disease (2004), The 30-Minute Fitness Solution (2001), and Hot Flashes, Hormones, & Your Health (2007).
(1) VITamin D and OmegA-3 TriaL (VITAL) (Principal Investigator): This large-scale randomized clinical trial (N=20,000 U.S. men and women) assesses the role of supplementation with vitamin D and the marine omega-3 fatty acids in the primary prevention of cancer and cardiovascular disease. A wide range of additional outcomes (hypertension, diabetes, cognitive function, mood/depression, physical performance, and autoimmune disorders) are being assessed in ancillary studies.
(2) Women's Health Initiative (Principal Investigator of Vanguard Clinical Center at Brigham and Women's Hospital): This national multicenter randomized clinical trial and observational study is addressing the balance of benefits and risks of hormone replacement therapy, low fat diet, and calcium/vitamin D supplementation. A total of 161,000 postmenopausal U.S. women were enrolled in the study nation‑wide.
(3) Women's Antioxidant and Folic Acid Cardiovascular Study (Principal Investigator): This investigator-initiated randomized clinical trial assessed the role of antioxidant micronutrients (vitamins C, E, and beta‑carotene) in the secondary prevention of cardiovascular events among 8000 high‑risk women with prior cardiovascular disease or multiple coronary risk factors. A homocysteine‑lowering component (with folic acid, B6, and B12) was added to the trial in 1998.
(4) Risk Factors for Cardiovascular Disease in Women (Principal Investigator): an epidemiologic study of determinants of coronary heart disease in women (the Nurses' Health Study cohort). A recent focus has been biochemical and genetic predictors of CHD.
(5) Kronos Early Estrogen Prevention Study (Principal Investigator of Boston center); a randomized clinical trial of transdermal vs oral estrogen vs placebo and atherosclerotic disease in recently menopausal women (aged 42-58). Additional components include cognitive function and quality of life measurements.
In addition, she collaborates on the following studies: Women’s Health Study, Nurses’ Health Study I and II, and Physicians’ Health Study I and II.
Visit Dr. Manson's Find A Researcher page
Muni RH, Kohly RP, Lee EQ, Manson JE, Semba RD, Schaumberg DA. Prospective study of inflammatory biomarkers and risk of diabetic retinopathy in the diabetes control and complications trial. JAMA Ophthalmol. 2013 Apr 1; 131(4):514-21.
Pai JK, Cahill LE, Hu FB, Rexrode KM, Manson JE, Rimm EB. Hemoglobin a1c is associated with increased risk of incident coronary heart disease among apparently healthy, nondiabetic men and women. J Am Heart Assoc. 2013; 2(2):e000077.
Chiuve SE, Sun Q, Curhan GC, Taylor EN, Spiegelman D, Willett WC, Manson JE, Rexrode KM, Albert CM. Dietary and plasma magnesium and risk of coronary heart disease among women. J Am Heart Assoc. 2013; 2(2):e000114.
Wild RA, Wu C, Curb JD, Martin LW, Phillips L, Stefanick M, Trevisan M, Manson JE. Coronary heart disease events in the Women's Health Initiative hormone trials: effect modification by metabolic syndrome: a nested case-control study within the Women's Health Initiative randomized clinical trials. Menopause. 2013 Mar; 20(3):254-60.
Pan A, Sun Q, Manson JE, Willett WC, Hu FB. Walnut consumption is associated with lower risk of type 2 diabetes in women. J Nutr. 2013 Apr; 143(4):512-8.