Severe, difficult-to-treat asthma remains a serious medical problem even in the current age of effective asthma therapies. In this Asthma Grand Rounds presentation, Dr. Bruce Levy – member of Partners Asthma Center and of the Pulmonary and Critical Care Division and Co-Director of the Medical Residency Program at Brigham and Women’s Hospital – discusses the lipid mediators called lipoxins and the role that they play in promoting resolution of inflammation. He shares the results of his research demonstrating a deficiency of lipoxins in severe asthma.