The research laboratories of the Department encompass a wide variety of areas and emphasize a modern, multi-disciplinary approach to pathophysiology and mechanisms of disease. Examples of current activities in the areas of emphasis in the basic research groups of the Department of Pathology at the Brigham and Women's Hospital are:
Vascular Biology: Leukocyte-endothelial interactions, molecular basis of endothelial gene expression and role of hemodynamic factors, targeted disruption of endothelial adhesion molecules, molecular mechanism of atherosclerosis.
Pulmonary Pathobiology: Mechanisms of inhalant-induced lung injury, the biology of alveolar macrophages, and the molecular basis of lung development, including neuroendocrine differentiation.
Immunology: Cellular interactions in immune responses, immunology of vascular endothelium, cytokines, lymphocyte activation and tolerance, targeted disruption of lymphocyte molecules, autoimmunity, and antigen presentation.
Molecular Oncology/Genetics: Molecular studies of onco-genes and tumor suppressor genes, analysis of chromosomal aberrations in cancer and benign disorders, control of DNA synthesis and the cell cycle, mechanisms of gene transcription, immunogenetics, receptor mediated control of cell differentiation, signal transduction, molecular methods of disease diagnosis, and the molecular genetics of hearing.
Topics of Research on Human Disease
- AIDS - Neuropathology Division
- ALZHEIMER'S DISEASE - Neuropathology Division
- ATHEROSCLEROSIS - Division of Vascular Biology Research
- BLADDER PATHOLOGY - Genitourinary Pathology
- BRAIN TUMORS - Neuropathology Division
- CARDIOVASCULAR DYSFUNCTION/CARDIAC DEVICE MALFUNCTION - Cardiac Pathology
- CEREBROVASCULAR DISEASES - Neuropathology Division
- CERVICAL AND VULVAR DISEASES - Women's and Perinatal Pathology Division
- CONNECTIVE TISSUE DISORDERS - Surgical Pathology Division
- FIBROIDS (LEIOMYOMAS) AND OTHER RELATED TUMORS - Women's and Perinatal Pathology Division
- GASTROINTESTINAL STROMAL TUMORS - Surgical Pathology Division
- GENETICS OF OVARIAN AND ENOMETRIAL CANCER - Women's and Perinatal Pathology Division
- HEARING AND DEVELOPMENTAL DISORDERS - Cytogenetics Division
- IMMUNE RESPONSES - Immunology Research Division
- INFLAMMATORY BOWEL DISEASE - Gastrointestinal Pathology
- KIDNEY CANCER - Genitourinary Pathology
- LIPOSARCOMAS - Surgical Pathology Division
- LUNG DISORDERS (health effects of inhaled particles and fibers) – Pulmonary Pathology
- MELANOMAS - Dermatopathology
- MUSCULOSKELETAL TUMORS - Surgical Pathology Division
- NEUROMUSCULAR DISEASES - Neuropathology Division
- PERINATAL NEUROLOGICAL DISEASES - Neuropathology Division
- PRENEOPLASTIC GI CONDITIONS - Gastrointestinal Pathology
- PROSTATE CANCER - Genitourinary Pathology
- SARCOMAS - Surgical Pathology Division
- SCREENING FOR CANCER: IMPROVED TECHNIQUES - Cytopathology Division
- SKIN LYMPHOMAS - Dermatopathology
- SOFT TISSUE TUMORS - Surgical Pathology Division
- SWEAT GLAND CANCERS - Dermatopathology
- UTERINE FIBROIDS - Cytogenetics Division
Perhaps you or a family member or friend has benefited from the diagnostic expertise of our department, or we are conducting research on a disease of interest to you. If so, you may wish to make a donation to one of the research programs in the department. To learn more about making a financial contribution to our research efforts, please contact the Development Office of Brigham and Women's Hospital (617-732.5008) or contact the director of the appropriate division.
Links to Research Sites
Cochlear EST Database
Endometrial Disease Research Dr. George Mutter
Dr. David Sacks' Laboratory Calmodulin Research
Dr. Mel Feany Laboratory Degenerative Neuological Diseases
Dr. Stephen Blacklow Laboratory Protein folding and protein-protein interactions
BWH Sarcoma Gene Expression Profiling Project
Dr. Charles Lee Cytogenetic Research Lab
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