| Principal Investigator(s): |
Julie E. Buring, ScD
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| Group Member(s): |
J. Michael Gaziano, MD
JoAnn E. Manson, MD
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| The Physicians' Health Study is a randomized, double-blind, placebo-controlled trial of the role of aspirin and beta-carotene in decreasing the risks of cardiovascular disease and cancer. This study has been conducted entirely by mail among 22,071 U.S. male physicians who were between the ages of 40 and 84 years when the trial began in 1982. The aspirin component of the trial was halted prematurely, in 1988, primarily because of a statistically extreme 44% reduction in risk of a first myocardial infarction among the group of men assigned to take low-dose aspirin. (Click here for a summary of the study results.) The beta-carotene component of the trial, which ended on schedule in 1995, found no evidence of either benefit or harm from beta-carotene supplements on risks of cancer or cardiovascular disease after more than 12 years of treatment and follow-up. (Click here for a summary of the study results.) |
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This page was last modified on 2/11/2008
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