|  Research Summary  |  Equipment & Techniques  |  Patents  | 
|  Funding  |  Publications  |

Research Summary

The overall interest of the laboratory is in epithelial dysfunction caused by inflammation, local or systemic. Two main projects are underway and funded. The first investigates the role of Zn2+ in preserving pH and internal environment in key acidic organelles of the acid secreting parietal cells and other epithelial cells of the GI tract. The second project seeks to characterize and understand the implications of disturbances in thiol redox potential and heavy metals (such as Zn2+) in serum and GI tissues subjected to inflammation caused by infection or systemic stress (shock or sepsis).

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Equipment & Techniques

Fluorescence Imaging System for cellular-level, real-time imaging of cells and multicellular units (such as gastric glands or colon crypts) in vitro.

Biotek 96 well plate reader for luminescence, fluorescence, spectrophotometry and colorimetry.

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Patents

Human calcium-sensing receptor in the detection and treatment of cancer - 6296833 (co-inventor with Edward Brown, MD

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Funding

1. NIH RO1 DK 06695 (PI: Soybel, 09/2005 - 08/2010) -- "Gastric injury in trauma and surgical sepsis"

2. NIH T32 DK0 07754 (PI: Soybel, 07/2004 - 06/2009) -- "Research training in alimentary tract surgery"

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Publications

To access Dr. David Soybel's publications, please click here.

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David Soybel
MD

Clinical Profile & Contact Information

Research Interests

Epithelial Dysfunction
Inflammation
Role of Zn2+
GI Tract