Past and Present Funding
Other Sponsors:
Marine Polymer
Tissue Engineering Research Fund
William F. Milton Fund
Back to the top
Current and Pending Grant Proposals -- Basic Science
CIMIT
We are in a phase II CIMIT study optimizing forces to stimulate blood vessel growth in our rat ear-stretch model. During this year, we hope to be able to optimize the waveform of mechanical stretch applied to the ears to optimally stimulate blood vessel development.
Adlyfe Corporation
Adlyfe Corporation has a proprietary method of freeze-drying platelets using a disaccharide (Trehalose) as a cryoprotectant. With support from the Department of Defense, we are studying the effects of these platelet concentrates in a diabetic mouse model. We are now working with them on applying for the first phase of a STTR award.
LifeCell Corporation
LifeCell Corporation has proposed using ThromboSol®, a platelet-stabilizing formulation consisting of second messenger effectors that inhibit specific activation pathways, as a cryoprotectant for freeze-dried platelets. We are completing a study of these platelets in a leptin deficient diabetic mouse model, and we have a preliminary agreement to extend the study to the action mechanism of these platelets.
Marine Polymers
Marine Polymers has provided funding for us to study the effect of N-acetal-glucosamine (NAG) on wound healing and hemostatic applications.
Hemedex Corporation
Hemedex Corporation has committed funding for a medical student to study the thermal perfusion probe as a summer research project.
DARPA
We are part of a 12-institution proposal submitted by the University of Indiana for a two year study. In this proposal we will study the effect of several specialized regeneration templates prepared by Dr. Yannas at MIT and analyzed by Dr. George Murphy at BWH.
Wound Healing Society
We have proposed to study the effects of human platelets in a diabetic mouse model. We are working with Dr. Peter Lapchak in Dr. Mannick’s laboratory who will assist us in concentrating platelets from mice.
National Endowment for Plastic Surgery
We are applying for an award to study the mechanism of vascular changes in soft tissues exposed to mechanical stretch. We propose that one mechanism is the development of intermittent hypoxia that up-regulates the NO pathway stimulating the production of VGEF.
NIH R-21 (1-R21-DE016585-01)
In July of 2004 we submitted a R-21 grant proposal that was not funded. We received positive reviews and hope that with more preliminary data, the proposal will be funded when we re-submit it later this year.
Back to the top
Current and Pending Grant Proposals -- Clinical Research
Kinetic Concepts Incorporated
Open Abdominal Wound Study – BWH was one of 10 centers randomizing patients to be treated with the VAC® vs. conventional treatment. Dr. Orgill is the lead investigator on this study, and is on a consensus panel to make recommendations on the appropriate use of this new technology.
Open Chest Study – BWH is one of 10 centers randomizing patients to VAC® vs. standard therapy. Dr. Orgill was the lead author in a consensus document recently published.
Pressure Sore Study – BWH is continuing the study started at Boston University comparing the VAC® with an advanced wound care modality Panafil.
Encelle Pharmaceuticals
Diabetic Foot Ulcer Study. Encelle manufactures an injectable collagen product that may be useful in wound healing. We were one site in a Phase II clinical trial
Synthes
Flammacerium in Burn Patients. We are part of a multi-centered trial comparing Flammacerium (Cerium Nitrate/Silver Sulfadiazine Cream) vs. Silver Sulfadiazine Cream.
Avocet Corporation
Incisional Scar Study. Avocet makes a scar cream with anti-inflammatory properties that we are designing a trial to compare efficacy in patients undergoing breast surgery.
Back to the top
Send Feedback to: 
