Keywords: transplant research, transplant immunology, ischemia, tolerance, innate immunity, age, donor treatment, immunogenicity
Please visit the Our Lab Website the Transplant Surgery Research Lab at tullius.partners.org.
The transplantation surgery laboratory’s main objective is to investigate clinically relevant questions in experimental models. In addition to answering basic science questions and unraveling relevant mechanisms, we also try to find clinical significance in experimental conclusions.
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Current Projects
Improvement of the quality of marginal donor organs following the perfusion/preservation with IGL-1:
Correlation between innate and adaptive immunity:
Immunogenicity and alloresponse Impact of donor treatment Synergism of prolonged ischemia and additional risk factors such as age, brain death, and diabetes. |
Consequences of increasing donor and recipient age:
Modified immune responses of elderly recipients Influence of graft age on the immune response Age adapted immunosuppression |
Defining criteria for clinical tolerance induction:
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Techniques
Histology, Immunohistology
PCR gene product identification and quantification
Real-time PCR
ELISA
Cytokine bead arrays
ELISPOT, flow cytometry
Proliferation assays
Rodent organ transplantation: cardiac, kidney, skin, thymus and islet transplantation in mouse and rat models
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1. Exposed donor situs,
renal vein + artery. | 2. After prep: exposed vessels + ureter. In order to perfuse in situ ligatures are placed above and below renal vessel around aorta. | 3. After perfusion (UW-solution). | 4. Subsequent recipient left sided Nephrectomy . Vessel clamps on renal artery and vein, ureter is held by forceps. |
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| 5. Arterial anastomosis is done by single stitching. You can see finished anastomsis. | 6. Transluminal continuous suture of recipient and donor vein. Arrow pointing at backside of vessel wall. | 7. Finished vessel anastomosis, ureter | 8. After reperfusion, in the back artery. |
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| 9. After reperfusion. Arrow points to ureter. | 10. Circular ureteral anastomosis using 5 to 6 single stitches. | 11. Treatment is finished. Kidney has good color and no tension on vessels/ureter. | |
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Funding Sources
Institut Geroges Lopez
Brigham and Women's Department of Surgery
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I. Original Articles
For the latest articles by Dr. Stefan Tullius please visit 
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Kotsch K, Martins PN, Klemz R, Janssen U, Gerstmayer B, Dernier A, Reutzel-Selke A, Kuckelkorn U, Tullius SG, Volk HD. Heme oxygenase-1 ameliorates ischemia/reperfusion injury by targeting dendritic cell maturation and migration. Antioxid Redox Signal. 2007 Dec;9(12):2049-63.
Chandraker A, Tullius SG. Induction therapy: are we picking our battles? Clin J Am Soc Nephrol. 2006 May;1(3):356-7. Epub 2006 Apr 12. No abstract available.
Gabardi S, Kubiak DW, Chandraker AK, Tullius SG. Invasive fungal infections and antifungal therapies in solid organ transplant recipients. Transpl Int. 2007 Dec;20(12):993-1015. Epub 2007 Jul 6.
Vadivel N, Tullius SG, Chandraker A. Chronic allograft nephropathy. Semin Nephrol. 2007 Jul;27(4):414-29. Review.
Pratschke J, Tullius SG. Promising recent data on ABO incompatible liver transplantation: restrictions may apply. Transpl Int. 2007 Aug;20(8):647-8. Review. No abstract available.
Weiss S, Kotsch K, Francuski M, Reutzel-Selke A, Mantouvalou L, Klemz R, Kuecuek O, Jonas S, Wesslau C, Ulrich F, Pascher A, Volk HD, Tullius SG, Neuhaus P, Pratschke J. Brain death activates donor organs and is associated with a worse I/R injury after liver transplantation. Am J Transplant. 2007 Jun;7(6):1584-93. Epub 2007 Apr 8.
Martins PN, Benckert C, Vetzke-Schlieker W, Pratschke J, Tullius SG, Neuhaus P. Intraduodenal diverticulum associated with a double common bile duct causing recurrent pancreatitis and cholangitis: report of a case. Surg Today. 2007;37(4):320-4. Epub 2007 Mar 26.
Reutzel-Selke A, Jurisch A, Denecke C, Pascher A, Martins PN, Kessler H, Tamura A, Utku N, Pratschke J, Neuhaus P, Tullius SG. Donor age intensifies the early immune response after transplantation. Kidney Int. 2007 Jan.
Kumamoto Y, Tamura A, Volk HD, Reinke P, Lohler J, Tullius SG, Utku N. TIRC7 is induced in rejected human kidneys and anti-TIRC7 mAb with FK506 prolongs survival of kidney allografts in rats. Transpl Immunol. 2006 Nov;16(3-4):238-44.
Martins PN, Reutzel-Selke A, Jurisch A, Denecke C, Attrot K, Pascher A, Kotsch K, Pratschke J, Neuhaus P, Volk HD, Tullius SG. Induction of carbon monoxide in donor animals prior to organ procurement reduces graft immunogenicity and inhibits chronic allograft dysfunction. Transplantation. 2006 Oct 15;82(7):938-44.
Pascher A, Proesch S, Pratschke J, Reutzel-Selke A, Sawitzki B, Lehmann M, Tullius SG, Neuhaus P, Volk HD, Reinke P. Rat cytomegalovirus infection interferes with anti-CD4 mAb-(RIB 5/2) mediated tolerance and induces chronic allograft damage. Am J Transplant. 2006 Sep;6(9):2035-45. Epub 2006 Jul 25.
Martins PN, Chandraker A, Tullius SG. Modifying graft immunogenicity and immune response prior to transplantation: potential clinical applications of donor and graft treatment. Transpl Int. 2006 May;19(5):351-9. Review.
Junge G, Schewior LV, Kohler S, Neuhaus R, Langrehr JM, Tullius S, Kahl A, Frei U, Neuhaus P. Acute renal failure after liver transplantation: incidence, etiology, therapy, and outcome. Transplant Proc. 2006 Apr;38(3):723-4.
Martins PN, Chandraker A, Tullius SG. Modifying graft immunogenicity and immune response prior to transplantation: potential clinical applications of donor and graft treatment. Transpl Int. 2006 May;19(5):351-9.
Kotsch K, Francuski M, Pascher A, Klemz R, Seifert M, Mittler J, Schumacher G, Buelow R, Volk HD, Tullius SG, Neuhaus P, Pratschke J. Improved long-term graft survival after HO-1 induction in brain-dead donors. Am J Transplant. 2006 Mar;6(3):477-86.
Hanninen EL, Denecke T, Stelter L, Pech M, Podrabsky P, Pratschke J, Ricke J, Schindler R, Neuhaus P, Felix R, Tullius SG. Preoperative evaluation of living kidney donors using multirow detector computed tomography: comparison with digital subtraction angiography and intraoperative findings. Transpl Int. 2005 Oct;18(10):1134-41.
Junge G, Tullius SG, Klitzing V, Schewior L, Pratschke J, Radke C, Neuhaus R, Neuhaus P. The influence of late acute rejection episodes on long-term graft outcome after liver transplantation. Transplant Proc. 2005 May;37(4):1716-7.
Junge G, Neuhaus R, Schewior L, Klupp J, Guckelberger O, Langrehr JM, Tullius S, Neuhaus P. Withdrawal of steroids: a randomized prospective study of prednisone and tacrolimus versus mycophenolate mofetil and tacrolimus in liver transplant recipients with autoimmune hepatitis. Transplant Proc. 2005 May;37(4):1695-6.
Kuecuek O, Mantouvalou L, Klemz R, Kotsch K, Volk HD, Jonas S, Wesslau C, Tullius S, Neuhaus P, Pratschke J. Significant reduction of proinflammatory cytokines by treatment of the brain-dead donor. Transplant Proc. 2005 Jan-Feb;37(1):387-8.
Martins PN, Keßler H, Jurisch A, Reutzel-Selke A, Kramer J, Pascher A, Pratschke J, Neuhaus P, Volk H-D, Tullius SG. Induction of heme oxygenase-1 (HO-1) in the donor reduces graft immunogenicity. Transplant. Proc. 2005; 37: 384-386.
Martins PN, Reutzel-Selke A, Jurisch A, Atrott A, Pascher A, Pratschke J, Buelow R, Neuhaus P, Volk H-D, Tullius SG. Induction of carbon monoxide in the donor reduces graft immunogenicity and chronic graft deterioration. Transplant. Proc. 2005; 37: 379-3381.
Reutzel-Selke A, Filatenkov A, Jurisch A, Denecke C, Martins PNA, Pascher A, Jonas S, Pratschke J, Neuhaus P, Tullius SG. Grafts from elderly donors elicit a stronger immune response in the early period post transplantation. Transplant. Proc. 2005; 37: 382-383.
Martins PN, Mashreghi MF, Reutzel-Selke A, Neuhaus P, Volk HD, Tullius SG, Kotsch K. Quantification of donor-derived DNA in serum: A new approach of acute rejection diagnosis in a rat kidney transplantation model. Transplant. Proc. 2005; 37: 87-88.
Kuecuek O, Mantouvalou L, Klemz R, Kotsch K, Volk HD, Jonas S, Wesslau C, Tullius S, Neuhaus P, Pratschke J. Significant reduction of proinflammatory cytokines by treatment of the brain-dead donor. Transplant. Proc. 2005; 37: 387-388.
Reutzel-Selke A, Filatenkov A, Denecke C, Martins PNA, Jurisch A, Pratschke J, Neuhaus P, Tullius SG. Die Transplantation älterer Spenderorgane führt zu einer modifizierten Immunantwort und einer ausgeprägten chronischen Transplantatdysfunktion. Springer Medizin Verlag, German Society of Surgery, Surgical Forum of Experimental und Clinical Research 2005.
Martins PN, Keßler H, Jurisch A, Reutzel-Selke A, Pascher A, Pratschke J, Neuhaus P, Volk H-D, Tullius SG. Die Induktion der Hämoxygenase-1 (HO-1) im Spender kurz vor Organentnahme reduziert die Immunogenität des Transplantates. Springer Medizin Verlag, German Society of Surgery, Surgical Forum of Experimental und Clinical Research 2005.
Pascher A, Pratschke J, Neuhaus P, Tullius SG. Modifications of immune regulations with increasing donor & recipient age. Ann. Transplant. 2004; 9: 72-73.
Pratschke J, Tullius SG, Neuhaus P. Brain death associated ischemia/reperfusion injury. Ann. Transplant. 2004; 9: 78-80.
Jonas S, Weinreich M, Tullius SG, Al-Abadi H, Steinbrich R, Radke C, Klupp J, Neuhaus P. Microscopic tumor cell dissemination in gastric cancer. Surg. Today 2004; 34: 101-106.
Senf R, Klingel R, Kurz S, Tullius SG, Sauer I, Frei U, Schindler R. Bilirubin-adsorption in 23 critically ill patients with liver failure. Int. J. Artif. Organs 2004; 27: 717-722.
Nickel P, Presber F, Bold G, Biti D, Schonemann C, Tullius SG, Volk HD, Reinke P. Enzyme-linked immunosorbent spot assay for donor-reactive interferon-gamma-producing cells identifies T-cell presensitization and correlates with graft function at 6 and 12 months in renal-transplant recipients. Transplantation 2004; 78: 1640-1646.
Hildebrandt B, Wust P, Drager J, Ludemann L, Sreenivasa G, Tullius SG, Amthauer H, Neuhaus P, Felix R, Riess H. Regional pelvic hyperthermia as an adjunct to chemotherapy (oxaliplatin, folinic acid, 5-fluorouracil) in pre-irradiated patients with locally recurrent rectal cancer: a pilot study. Int. J. Hyperthermia. 2004; 20: 359-369.
Pratschke J, Paz D, Wilhelm MJ, Laskowski I, Kofla G, Vergopoulos A, MacKenzie HJ, Tullius SG, Neuhaus P, Hancock WW, Volk HD, Tilney NL. Donor hypertension increases graft immunogenicity and intensifies chronic changes in long-surviving renal allografts. Transplantation 2004; 77: 43-48.
Seehofer D, Rayes N, Schiller R, Stockmann M, Muller AR, Schirmeier A, Schaeper F, Tullius SG, Bengmark S, Neuhaus P. Probiotics partly reverse increased bacterial translocation after simultaneous liver resection and colonic anastomosis in rats. J. Surg. Res. 2004; 117: 262-271.
Baid-Agrawal S, Reinke P, Schindler R, Tullius S, Frei U. WCN 2003 satellite symposium on kidney transplantation in the elderly, Weimar, Germany, June 12-14, 2003. Congress Report. Nephrol. Dial. Transplant. 2004; 19: 43-46.
Pascher A, Reutzel-Selke A, Bachmann U, Jurisch A, Pratschke J, Volk H-D, Tullius SG. Alterations of the immune response with increasing recipient age are associated with reduced long-term organ graft function of rat kidney allografts. Transplantation 2003; 76: 1560-1568.
Reutzel-Selke A, Zschockelt T, Denecke C, Bachmann U, Jurisch A, Pratschke J, Schmidbauer G, Volk H-D, Neuhaus P, Tullius SG. Short-term immunosuppressive treatment of the donor ameliorates consequences of ischemia/reperfusion injury and long-term graft function in renal allografts from older donors. Transplantation 2003; 75: 1786-92.
Heidenhain C, Reutzel-Selke A, Bachmann U, Jonas S, Pascher A, Ulrich F, Pratschke J, Volk H-D, Tullius SG. The impact of immune-activating processes following transplantation on chronic allograft nephropathy. Kidney Int. 2003; 64: 1125-1133.
Pascher, A, Reutzel-Selke A, Bachmann U, Jurisch A, Pratschke J, Neuhaus P, Volk H-D, Tullius SG. Die intensivierte zelluläre Immunantwort in älteren Empfängern verstärkt die chronische Transplantatabstoßung in einem experimentellen Nierentransplantationsmodell. Langenbecks Archives of Surgery 2003 (suppl.), Surgical Forum of Experimental und Clinical Research.
Tullius SG, Pratschke J, Strobelt V, Kahl A, Reinke P, May G, Frei U, Neuhaus P. ATG versus basiliximab induction therapy in renal allograft recipients receiving a dual immunosuppressive regimen: one-year results. Transplant. Proc. 2003; 35: 2100-2101.
Tullius SG, Schmidbauer G, Pratschke J, Ulrich F, Reutzel-Selke A, Steinmüller T, Volk H-D, Neuhaus P. Kurzzeit Immunsuppresion des sogenannten marginalen Spenders zur Verbesserung der Transplantatfunktion. Langenbecks Arch. Surg. 2003 (suppl.), Surgical Forum of Experimental und Clinical Research.
Schindler R, Tullius SG, Tanriver Y, Noack K, Qun Y, Jurgensen JS, Frei U. Hypertension increases expression of growth factors and MHC II in chronic allograft nephropathy. Kidney Int. 2003; 63: 2302-2308.
Jonas S, Steinmüller T, Tullius SG, Thelen A, Settmacher U, Berg T, Radtke C, Neuhaus P. Increased mortality after liver transplantation for hepatocellular carcinoma in hepatitis B-associated cirrhosis. Transpl. Int. 2003; 16: 33-36.
Benckert C, Jonas S, Cramer T, Tullius SG, Rosewicz S, Neuhaus P. TGF-beta 1 stimuliert die VEGF-Gentranskription im Humanen Cholangiozellulären Karzinom. Langenbecks Arch. Surg. 2003 (suppl.), Surgical Forum of Experimental und Clinical Research.
Ulrich F, Steinmüller T, Gärtner M, Tullius SG, Kamm B, Neuhaus P. Endokrine Sekretion und physiologische Steuerbarkeit von humanem Nebenschilddrüsengewebe nach Mikroenkapsu-lierung mit Natriumcellulosesulfat und Poly-DADMAC. Langenbecks Arch. Surg. 2003 (suppl.), Surgical Forum of Experimental und Clinical Research 32: 561-563.
Pratschke J, Kordic M, Kotsch K, Pascher A, Tullius SG, Volk H-D, Neuhaus P. Risikofaktor Hirntod - Einflüsse der Induktion protektiver Gene auf die Transplantatfunktion. Langenbecks Arch. Surg. 2003 (suppl.), Surgical Forum of Experimental und Clinical Research.
Pascher A, Schläfke S, Wiedenmann B, Radke C, Tullius SG, Müller AR, Steinmüller T, Neuhaus P. Stellenwert der resektiven chirurgischen Therapie und positive prognostische Faktoren in der Behandlung hepatisch metastasierter neuroendokriner Tumore. Langenbecks Arch. Surg. 2003 (suppl.), Surgical Forum of Experimental und Clinical Research.
Yang J, Reutzel-Selke A, Steier C, Jurisch A, Tullius SG, Sawitzki B, Kolls J, Volk HD, Ritter T. Targeting of Macrophage Activity by Adenovirus-mediated intragraft overexpression of TNFRp55-Ig, IL-12p40, and vIL-10 ameliorates adenovirus-mediated chronic graft injury, whereas stimulation of macrophages by overexpression of IFN-gamma accelerates chronic graft injury in a rat renal allograft model. J. Am. Soc. Nephrol. 2003; 14: 214-225.
Fritsche L, Horstrup J, Budde K, Reinke P, Giessing M, Tullius SG, Loening S, Neuhaus P, Neumayer HH, Frei U. Old-for-Old Kidney Allocation Allows Successful Expansion of the Donor and Recipient Pool. Am. J. Transplant. 2003; 3: 1434-1439.
Filatenkov A, Schmidt H, Reutzel-Selke A, Seifert M, Doebis C, Jurisch A, Pratschke J, Neuhaus P, Volk HD, Tullius SG. Initial organ engraftment with a short-term low-dose CyA treatment induces tolerance for consecutive grafts in a model of strong histoincompatibility. Transplant. Proc. 2002; 34: 2895-2896.
Tullius SG, Nieminen-Kelhä M, Buelow R, Reutzel-Selke A, Pratschke J, Bachmann U, Lehmann M, Southard D, Iyer S, Sawitzki B, Reinke P, Neuhaus P, Volk H-D. Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single donor treatment for the induction of heme oxygenase-1. Transplantation 2002; 74: 591-598.
Tullius SG, Filatenkov A, Horch D, Mehlitz T, Pratschke J, Jonas S, Lun A, Al-Abadi H, Neuhaus P. Accumulation of crystal deposits in abdominal organs following perfusion with defrosted University of Wisconsin solutions. Am. J. Tranplant. 2002; 2:627-630.
Tullius SG, Bachmann U, Heidenhain C, Reutzel-Selke A, Jurisch A, Filatenkov A, Pratschke J, Jonas S, Steinmüller T, Volk HD, Neuhaus P. Early cellular markers for the prediction of chronic graft deterioration in a retransplantation model. Transplant. Proc. 2002; 34: 2357-2358.
Seehofer D, Rayes N, Tullius SG, Schmidt CA, Neumann UP, Radke C, Settmacher U, Muller AR, Steinmuller T, Neuhaus P. CMV hepatitis after liver transplantation: Incidence, clinical course and long-term follow-up. Liver Transpl. 2002; 8: 1138-1146.
Kotsch K, Kordic M, Buelow R, Tullius SG, Volk H, Neuhaus P, Pratschke J. HO-1 induction in brain dead donors leads to improved organ survival. Hum. Immunol. 2002; 63(suppl): S67.
Ulrich F, Jonas S, Steinmüller T, Seehofer D, Tullius SG, Neuhaus P. Chirurgische Therapie von Präkanzerosen und frühen Karzinomen der Leber. Chir. Gastroenterol. 2002; 18: 134-140.
Jonas S, Guckelberger O, Muller AR, Langrehr JM, Settmacher U, Tullius SG, Steinmuller T, Neuhaus P. Cyclosporine-based quadruple induction therapy versus tacrolimus-based dual immunosuppression after liver transplantation: ten-year follow-up. Transplant. Proc. 2002; 34: 1504-1506.
Seehofer D, Steinmüller T, Gräf KJ, Rayes N, Wiegand W, Tullius SG, Settmacher U, Neuhaus P. Pituitary function test and endocrine status in patient with cirrhosis of the liver before and after hepatic transplantation. Ann. Transplant. 2002; 7: 32-37.
Ulrich F, Steinmüller T, Settmacher U, Müller AR, Jonas S, Tullius SG, Neuhaus P. Therapy of Caroli's disease by orthotopic liver transplantation. Transplant Proc. 2002 34: 2279-2280.
Ulrich F, Steinmüller T, Lang M, Settmacher U, Müller AR, Jonas S, Tullius SG, Neuhaus P. Liver transplantation in patients with advanced Budd-Chiari syndrome. Transplant. Proc. 2002; 34: 2278.
Pratschke J, Kofla G, Wilhelm M, Vergopoulos A, Laskowski I, Shaw GD, Tullius SG, Volk HD, Neuhaus P, Tilney NL. Improvements in early behaviour of kidney allografts after donor treatment. Transplant. Proc. 2002; 34: 2213-2214.
Schmidt H, Filantenkov A, Reutzel-Selke A, Seifert M, Doebis C, Jurisch A, Pratschke J, Neuhaus P, Tullius SG, Volk HD. Adoptive transfer of regulatory T cells following chronic allograft rejection induces tolerance for secondary allografts. Transplant. Proc. 2002; 34: 2893-2894.
Tullius SG, Nieminen.Kelhä M, Reutzel-Selke A, Bachmann U, Jonas S, Pratschke J, Bechstein WO, Volk HD, Bülow R, Neuhaus P, Reinke P. Improvement of long-term function in renal allografts from ‘marginal donors‘ following the induction of Hemeoxygenase-1 (HO-1). Transplant. Proc. 2001; 33: 1160.
Tullius SG, Nieminen-Kelhä M, Bachmann U, Reutzel-Selke A, Jonas S, Pratschke J, Bechstein WO, Reinke P, Bülow R, Neuhaus P, Volk HD. Induction of Hemeoxygenase-1 (HO-1) prevents ischemia/reperfusion injury (I/R) and improves long-term graft outcome in rat renal allografts. Transplant. Proc. 2001; 33: 1286.
Tullius SG, Jonas S, Pratschke J, Bülow R, Volk H-D, Neuhaus P. Verbesserung der Transplantatfunktion marginaler Spenderorgane durch Induktion der Hämoxygenase-1 (HO-1). Langenbecks Arch. Surg. 2001 (suppl.), Surgical Forum of Experimental und Clinical Research 2001; 30: 285-287.
Tullius SG, Reutzel-Selke A, Nieminen-Kelhä M, Jonas S, Pratschke J, Bechstein WO, Neuhaus P, Volk HD. Tolerance induction by the graft itself. Transplant. Proc. 2001; 33: 2317-2318.
Tullius SG, Reutzel-Selke A, Bachmann U, Jurisch A, Nieminen-Kelha M, Pratschke J, Jonas S, Steinmuller T, Volk HD, Neuhaus P. Influence of recipient and donor age on long-term renal allograft function in an experimental model. Transplant. Proc. 2001; 33: 3345-3346.
Reutzel-Selke A, Tullius SG, Zschockelt T, Bachmann U, Nieminen.Kelhä M, Jonas S, Pratschke J, Bechstein WO, Volk HD, Neuhaus P. Donor-pretreatment of grafts from marginal donors improves long-term graft outcome. Transplant. Proc. 2001; 33: 970.
Jonas S, Guckelberger O, Tullius SG, Steinmüller T, Muller AR, Grauhan O, Langrehr JM, Bechstein WO, Neuhaus P. Corticosteroid-free therapy after tacrolimus-based dual immunosuppression versus cyclosporine-based quadruple-induction therapy. Transplant. Proc. 2001; 33: 2232-2233.
Jonas S, Herrmann M, Rayes N, Berg T, Radke C, Tullius SG, Settmacher U, Steinmuller T, Neuhaus P. Survival after liver transplantation for hepatocellular carcinoma in cirrhosis according to the underlying liver disease. Transplant. Proc. 2001; 33: 3444-3445.
Pratschke J, Wilhelm MJ, Laskowski M, Kusaka M, Paz D, Tullius SG, Neuhaus P, Hancock WW, Tilney NL. The influence of donor brain death on long-term function of renal allotransplants in rats. Transplant. Proc. 2001; 33: 693.
Pratschke J, Wilhelm MJ, Laskowski M, Kusaka M, Beato F, Tullius SG, Neuhaus P, Hancock WW, Tilney NL. Influence of donor brain death on chronic rejection of renal transplants in rats. J. Am. Soc. Nephrol. 2001; 12: 2474-2481.
Seehofer D, Rayes N, Naumann U, Neuhaus R, Müller AR, Tullius SG, Berg T, Steinmüller T, Bechstein WO, Neuhaus P. Preoperative antiviral treatment and postoperative prophylaxis in HBV-DNA positive patients undergoing liver transplantation. Transplantation 2001: 72: 1381-1385.
Steinmüller T, Ulrich F, Rayes N, Lang M, Seehofer D, Tullius SG, Jonas S, Neuhaus P. Operationsverfahren und Risikofaktoren in der Therapie der benignen Struma multinodosa. Der Chirurg 2001; 72: 1453-1457.
Pratschke J, Kofla G, Wilhelm MJ, Vergopoulos A, Laskowski I, Shaw GD, Tullius SG, Volk H-D, Neuhaus P, Tilney NL. Improvements in early behaviour of kidney allografts after treatment of the brain-dead donor. Ann. Surg. 2001; 234: 732-740.
Tullius SG, Reutzel-Selke A, Nieminen-Kelhä M, Egermann F, Jonas S, Bechstein WO, Volk HD, Neuhaus P. The contribution of prolonged ischemia and donor age on chronic renal allograft dysfunction. J. Am. Soc. Nephrol. 2000; 11: 1317-1324.
Tullius SG, Pratschke J, Hancock WW, Neuhaus P. Abschaltung des neutrophilen Rezeptors CCRI schützt vor Ischämie-, Reperfusionsschäden. Langenbecks Arch. Surg. 2000 (suppl.), Surgical Forum of Experimental und Clinical Research 2000; 29: 169-172.
Reutzel-Selke A, Tullius SG, Graser E, Nieminen-Kelhä, Jonas S, Bechstein WO, Neuhaus P, Volk HD. Mechanisms of tolerance induction in second renal allografts of a chronic rejection model. Transplant. Int. 2000; 13 (suppl.): 476-479.
Pratschke J, Wilhelm M, Hancock WW, Tullius SG, Tilney NL, Neuhaus P. Einflüsse des Hirntodes auf die Langzeitfunktion allogener und isogener Nierentransplantate. Langenbecks Arch. Surg. 2000 (suppl.), Surgical Forum of Experimental und Clinical Research 2000; 29: 241-244.
Neuhaus P, Klupp J, Langrehr JM, Neumann U, Gebhardt A, Pratschke J, Tullius SG, Lohmann R, Radke C, Rayes N, Neuhaus R, Bechstein WO. Quadruple Tacrolimus-based induction therapy including Azathioprine and ALG does not significantly improve outcome after liver transplantation when compared with standard induction with Tacrolimus and steroids: results of a prospective, randomized trial. Transplantation 2000; 69: 2343-2353.
Braun C, Conzelmann T, Vetter S, Schaub M, Back WE, Kirchengast M, Tullius SG, Schnulle P, van der Woude F, Rohmeiss P. Treatment with a combined endothelin A/B-receptor antagonist does not prevent chronic renal allograft rejection in rat. J. Cardiovasc. Pharmacol. 2000; 36: 428-437.
Click here for Dr. Tullius' pre-2000 publications.
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II. Book Chapters & Reviews
Martins PNA, Pratschke J, Pascher A, Fritsche L, Frei U, Neuhaus P, Tullius SG. Age and immune response in organ transplantation. Transplantation 2005; 79: 127-132.
Pratschke J, Neuhaus P, Tullius SG. What can be learned from brain-death models? Transplant. Int. 2005; 18: 15-21.
Tullius, SG, Neuhaus P: Handbuch Transplantation: Pankreastransplantation, Medizinische Medien Informations GmbH, Neu-Isenburg, 2004.
Tullius SG, Neuhaus P. The marginal kidney donor. Curr. opin. Urol. 2002; 12: 101-107.
Stark K, Gunther M, Schonfeld C, Tullius SG, Bienzle U. Immunisations in solid-organ transplant recipients. Lancet 2002; 359: 957-65.
Pratschke J, Tullius SG, Neuhaus P. Immunosuppression in solid organtransplantation: a review. Graft 2002; 5: 338-343.
Tullius SG, Pratschke J, Neuhaus P: Die Transplantation von Nieren eingeschränkter Qualität. In: Langzeitüberleben nach Nierentransplantation sichern. U. Frei, J. Klempnauer, B. Ringe, H. Sperschneider (Hrsg.); Springer Verlag , Heidelberg, 2001.
Tullius SG, Neuhaus P. Die chronische Transplantatdysfunktion. Eingeschränkter Langzeiterfolg nach Organtransplantation. Humboldt Spektrum 2001; 1: 4-8.
Tullius SG, Pfitzmann R, Neuhaus P. Nierentransplantation. In: Thorakale und abdominale Organtransplantation. R. Pfitzmann, P. Neuhaus, R. Hetzer (Hrsg.); De Gruyter, Berlin-New York, 2001.
Tullius SG, Volk HD, Neuhaus P. Transplantation of organs from marginal donors. Transplantation 2001; 72:1341-1349.
Buelow R, Tullius SG, Volk H-D. Protection of grafts by hemeoxygenase-1 and its toxic product carbon monoxide. Am. J. Transplant. 2001; 1: 313-315.
Pratschke J, Tullius SG, Jonas S, Neuhaus P: Risikofaktor Hirntod. In: Langzeitüberleben nach Nierentransplantation sichern. U. Frei, J. Klempnauer, B. Ringe, H. Sperschneider (Hrsg.); Springer Verlag , Heidelberg, 2001.
Bechstein WO, Tullius SG. Maintenance immunosuppression after renal transplantation: identify those who need little or less. Transplantation 2000; 70 (1): 2-3.
Heemann UW, Tullius SG, Azuma H, Schmid C, Tilney NL. Influence of laminin and fibronectin on leucocyte infiltration following surgery. In: The immune consequences of trauma, shock and sepsis. Mechanisms and therapeutic approaches. Faist E, Bauer AE, Schildberg FW (eds), Pabst Science Publishers; 1996: 628-634.
Tullius SG, Sablinski T, Heemann UW, Kupiec-Weglinski JW, Tilney NL: Immunobiolgy of heart rejection in experimental models. In: Immunology of heart and lung transplantation. Yacoub and Rose (ed) Edward Arnold, England 1993; 42-57.
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Staff
Steven McGuire -- Lab Manager
Xupeng Ge, MD PhD, Post-Doctoral Research Fellow
Damanpreet Singh Bedi, MD, Surgical Fellow
Irene Kim, MD, Surgical Fellow
Anke Jurisch, Technical Research Assistant
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