Anne CC Lee, MD, MPH, of the Department of Pediatric Newborn Medicine, received a K23, five-year Career Development Award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) for her grant proposal, “The role of perinatal nutrition, infection and inflammation in the neurodevelopment of Bangladeshi infants.”
This grant will allow Lee to expand her investigation into neurodevelopment and build a multidisciplinary research program in perinatal health in low-income countries.
Lee plans to test the hypothesis that maternal undernutrition and infections in pregnancy place the fetus at greater risk of inflammation, and, in turn, at risk of brain white-matter injury and long-term neuro-developmental impairment in childhood.
Lee will study a cohort of 300 Bangladeshi mothers and infants, exploring the role of perinatal nutrition and inflammation in brain growth and neurodevelopmental outcomes at two years old. She hopes that the expertise, knowledge and pilot data gained from the K23 program will enable her to lead a randomized controlled trial of interventions in pregnancy to optimize neurodevelopment among children in low-income countries.