Publications

Articles
  1. Mihm MC Jr, Clark WH Jr, From L. The clinical diagnosis, classification and histogenetic concepts of the early stages of cutaneous malignant melanoma. N Engl J Med. 1971; 284:1078-1082.
  2. Mihm MC Jr, Fitzpatrick TB, Lane-Brown MD, Raker JW, Malt RA, Kaiser JS. Early detection of cutaneous malignant melanoma: A color atlas. N Engl J Med. 1973; 289:989-996. Reprinted In: Cancer Manual, 6th ed., Amer Cancer Soc, Mass Div, Inc. 1985; 12:104-111.
  3. Dvorak HF, Mihm MC Jr, Dvorak AM, Barnes BA, Manseau EJ, Galli SJ. Rejection of first set skin allografts in man. The microvasculature is the critical target of the immune response. J Exp Med. 1979; 150:322-337.
  4. Mihm MC Jr, Clemente CG, Cascinelli N.  Tumor Infiltrating Lymphocytes in Lymph Node Melanoma Metastases:  A Histopathologic Prognostic Indicator and an Expression of Local Immune Response. Lab. Invest. 1996, 74:1, 43-47.
  5. Soiffer R, Lynch T, Mihm MC Jr, Jung K, Rhuda C, Schmollinger JC, Hodi FS, Liebster L, Lam P, Mentzer S, Singer S, Tanabe KK, Cosimi AB, Duda R, Sober A, Bhan A, Daley J, Neuberg D, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Clift S, Cohen LK, Mulligan RC, Dranoff G.  Vaccination with irradiated autologous melanoma cells engineer to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma.  Proc. Natl. Acad. Sci USA,1998. Vol 95; 13141-13146.
  6. North PE, Mizeracki A, Waner M, and Mihm MC, Jr:  GLUT1: a newly discovered marker for juvenile hemangiomas.  Human Pathology: 31(1):11-22, 2000.
  7. Dadras SS, Paul T, Bertoncini J, Brown LF, Muzikansky A, Jackson DG, Ellwanger U, Garbe C, Mihm MC, Detmar M.  Tumor lymphangiogenesis:  a novel prognostic indicator for cutaneous melanoma metastasis and survival.  Am J Pathol 2003; 162(6):1951-60.
  8. Magro CM, Crowson AN, Mihm MC Jr.  Unusual variants of malignant melanoma. Mod Pathol. 2006:19,S41-S70.
  9. Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, Macrae S, Nelson M, Canning C, Lowy I, Korman A, Lautz D, Russell S, Jaklitsch MT, Ramaiya N, Chen TC, Neuberg D, Allison JP, Mihm MC, Dranoff G.  Immunologic and Clinical Effects of Blockade of Cytotoxic T Lymphocyte-Associated Antigen 4 in Previously Vaccinated Cancer Patients.  Proc Natl Acad Sci USA.  2008 Feb 26; 105 (8):3005-10.
  10. Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty PA, Kirkwood JM, McMasters KM, Mihm MC Jr, Morton DL, Ross MI, Sober AJ, Sondak VK.  Final Version of 2009 AJCC Melanoma Staging and Classification. J Clin Oncol. 2009 Dec 20;27(36):6199-206.
  11. Scolyer R, Thompson JF, O’Toole, SA, Karim RZ, Mihm MC Jr., McCarthy SW, Murali R.  Recent advances and important issues in melanoma pathology: An update for oncologists.  Cancer Forum. 2012 Nov 136(3):151-158.
  12. Gao L, Phan S, Nadora DM, Chernova M, Sun V, Preciado SM, Ballew B, Jia Z, Jia W, Wang G, Mihm MC Jr, Nelson JS, Tan W. Topical rapamycin systematically suppresses the early stages of pulsed dye laser-induced angiogenesis pathways.  Lasers Surg Med. 2014 Nov;46(9):679-88

Books

Pathobiology and Recognition of Malignant Melanoma (International Academy of Pathology Monograph)

Williams & Wilkins

Publication Date: June 1988

Author: Martin C. Mihm, Jr.

Problematic Pigmented Lesions: A Case Method Approach

Lea & Febiger

Publication Date: May 1990

Authors: Martin C., Jr. Mihm, Paul B. Googe, Arthur K. F. Tong

 

Color Atlas and Synopsis of Pigmented Lesions

McGraw-Hill Education (ISE Editions)

Publication Date: February 1, 1995

Authors: Raymond L. Barnhill, Katrin Fandrey, Martin C. Mihm Jr, Arthur J. Sober, Thomas B. Fitzpatrick

This work provides a comprehensive summary of benign and malignant pigmented lesions and their differential diagnosis. It covers points of interest such as epidemiological data, aetiology, clinical and histological features, biological behaviour, treatment and prognosis, and gives a survey of the current literature. It is written for dermatologists, those working in paediatrics, general practioners and students.

 

The Melanocytic Proliferation: A Comprehensive Textbook of Pigmented Lesions

Wiley-Liss; 1st edition

Publication Date: October 15, 2001

Authors: A. Neil Crowson, Cynthia M. Magro, Martin C. Mihm, Jr.

The rising number of incidences of melanoma has led to increased interest in the disease from diagnostic, management, and basic science perspectives. The Melanocytic Proliferations describes the pathobiology of pigmented melanocytic lesions, and provides guidelines for their diagnosis and management as they affect the skin and mucosas.

Extensively illustrated, this book is divided into four parts: the biology of melanocytes and malignant melanoma; nonmelanocytic lesions (e.g., lentigo, congenital nevi, compound nevi); melanocytic lesions with the potential to develop as melanoma (e.g., dysplastic nevi); and malignant melanoma (e.g., radial and vertical growth phases). Offering extensive discussions of each lesion, The Melanocytic Proliferations covers clinical applications, histology, differential diagnostic features, diagnostic algorithms, immunohistochemistry, electromicroscopy, and, where applicable, treatment, prognosis, and adjuvant therapy.

The Melanocytic Proliferations is an excellent and indispensable resource for dermatologists, pathologists, dermapathologists, and surgical pathologists.

 

Primer of Dermatopathology (Book with CD-ROM)

Lippincott Williams & Wilkins; Third edition

Publication Date: July 15, 2002

Authors: Antoinette F. Hood, Theodore H. Kwan, Martin C. Mihm, Jr. Thomas D. Horn, Bruce R. Smoller

Featuring nearly 400 clear, sharp photomicrographs, the Third Edition of this primer is a user-friendly guide to interpreting skin biopsies. Abnormalities are grouped according to location in the skin and morphologic characteristics. Each abnormality is discussed in an easy-to-follow three-column format. The first column lists the disease entities. The second column lists histologic criteria for diagnosis, with key features in boldface. The third column presents the differential diagnosis, helpful hints, and clinical information. Adjacent to the text are representative photomicrographs, accompanied where necessary by drawings to clarify cellular structures. New to this edition is a bound-in CD-ROM that contains over 2,000 full-color photomicrographs with more than 300 multiple-choice questions and answers for review and self-assessment.

 

The Cutaneous Lymphoid Proliferations: A Comprehensive Textbook of Lymphocytic Infiltrates of the Skin

Wiley Publications

Publication Date: March 16, 2007

Authors: Cynthia M. Magro, A. Neil Crowson, Martin C. Mihm, Jr.

A complete reference to the latest understanding of lymphocytic infiltrates

The Cutaneous Lymphoid Proliferations provides a complete, authoritative treatment of the clinical features, phenotypes, pathogenesis, histopathology, diagnosis, and treatment of lymphocytic infiltrates of the skin. Incorporating the latest findings from the fields of light microscopy, immunohistochemistry, and flow cytometry, the book brings readers up to date on the most current thinking in the field. Those readers familiar with the authors' critically acclaimed The Melanocytic Proliferations will find a similar structure and the same attention to detail and quality in this latest reference.

The book starts off with a clinical atlas and introduction to the ontogeny and biology of the lymphoid system. Next, the authors explore novel molecular approaches to the diagnosis of cutaneous lymphoid proliferations and benign lymphocytic infiltrates. The remaining chapters concentrate on major inflammatory skin diseases and lymphoproliferative disorders, including chronic lymphocytic leukemia, lupus, adult T cell leukemia, and primary cutaneous Hodgkin's disease.

As a reference to lymphocytic infiltrates, this book is unsurpassed. Novice and experienced practitioners alike will gain important insights into the field, including:

  • The role of the immune system in the pathogenesis of cutaneous disease
  • Relationships between therapeutic drugs and cutaneous eruptions
  • Important drug reactions

Hundreds of full-color, high-quality clinical and histologic photographs help readers visualize the various infiltrates and their treatments. Having this reference on hand is essential for all dermatologists, dermatopathologists, oncologists, and general pathologists who need a synthesis of the current thinking in the field.

 

Biopsy Interpretation of the Skin: Primary Non-Lymphoid Neoplasms of the Skin
Lippincott Williams & Wilkins

Publication Date: December 1, 2010

Authors: Martin C. Mihm, Jr., Cynthia M. Magro A. Neil Crowson

This new volume of the Biopsy Interpretation Series is a practical, superbly illustrated reference on the primary non-lymphoid neoplasms of the skin. The book offers guidelines on how and when to biopsy the skin and then discusses benign melanocytic proliferations, precursor lesions to melanoma, and melanomas. Also included are discussions of basal cell carcinoma, squamous cell carcinoma and its precursors, benign and malignant adnexal neoplasms, and soft tissue neoplasms of the skin and superficial subcutis. A major highlight of the book is the extensive discussion of differential diagnostic considerations and their separation from the main diagnostic entities under consideration. The book features nearly 300 full-color images. A companion Website will provide 400 additional figures, plus a test bank that is ideal for board exam preparation.
Inflammatory Disorders of the Skin (Atlas of Nontumor Pathology)

American Registry of Pathology; 1 edition

Publication Date: September, 2012

Authors: George F. Murphy, Arturo P. Saavedra, Martin C. Mihm, Jr.

Because inflammatory skin disorders represent the most common and significant non-neoplastic skin diseases, as well as the most frequently encountered diagnostic hurdle for the practicing patholo­gist, they are the focus of this volume. This Atlas seeks to summarize and illuminate relevant clinical and pathologic findings for non-neoplastic disorders of skin in the context of recent knowledge and in a manner that promotes practicality. Non-neoplastic diseases of the skin are ubiquitous and numerous. They are re­sponsible for significant morbidity in patients worldwide and account for enormous time consumption and cost within the medical community. The authors hope that this Fascicle will facilitate the diagnosis and treatment of these important conditions in a manner that will benefit patients and clinicians alike.

 

Dermatopathology: Clinicopathological Correlations

Springer; 2014 edition

Publication Date: December 8, 2013

Authors: Clay Cockerell, Martin C Mihm Jr., Brian Hall, Cary Chisholm, Chad Jessup, Margaret C. Merola

Dermatopathology is a specialized branch of pathology in which there has been great progress as new techniques have become available to evaluate the pathology of the skin. Many of the advances in our knowledge and understanding of the skin and the diseases that affect it have been made by people with experience of both diagnostic pathology and clinical dermatology. With significant numbers of large textbooks available, there is a need to provide practical clinical information and concise criteria for pathologic diagnosis for pathologists and dermatologists looking for up-to-date diagnostic and management options.

 

The Melanocytic Proliferations: A Comprehensive Textbook of Pigmented Lesions

Wiley Publications

Publication Date: 3/17/2014

Authors: Martin C. Mihm Jr., M.D., A. Neil Crowson, Cynthia Magro, M.D.

A thorough updating of this best-selling textbook, The Melanocytic Proliferations is the most comprehensive single-source treatment of the subject available. Presenting an experience- and evidence-based review of pigmented lesions encompassing the biology, diagnosis, and treatment of melanocytic proliferations and disorders, including malignant melanoma, this fully revised second edition contains three completely new chapters: Staging of Melanoma, Dermoscopy and its relationship to the histomorphology of select pigmented lesions, and Confocal microscopy of melanoma subtypes. The text includes over 300 new, additional color images.

 

Melanocytic Lesions: A Case Based Approach
Springer; 2014 edition

Publication Date: June 26, 2014

Authors: Mai P. Hoang, Martin C Mihm Jr.

Melanocytic Lesions: A Case Based Approach provides a concise yet comprehensive guideline on how to diagnose common as well as problematic and challenging melanocytic lesions. In the first 11 chapters, each entity is illustrated by an actual case; followed by discussion of how the diagnosis is reached, of the histologic differential diagnoses and of diagnostic pitfalls and ends with bulleted teaching points. Pertinent and up to date references are included at the end of each chapter. The latter chapters cover current microstaging and classification of melanoma, ancillary techniques including immunohistochemistry as well as available molecular assays and molecular targeted therapy. All figures and glass slides of the discussed cases are hosted online for easy viewing and access. Melanocytic Lesions: A Case Based Approach will serves as a useful resource for pathologists, dermatologists and researchers dealing with melanocytic lesions.

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