The Allergy and Immunology program at Brigham and Women’s Hospital has made pioneering advancements in Allergy and Immunology for more than 50 years and continues to be one of the largest research groups in Allergy and Immunology in the country. Basic science discoveries have included seminal work on the identification of cysteinyl leukotrienes and their receptors in anaphylaxis and asthma, identification of exercise-induced anaphylaxis as a form of physical allergy, elucidation of mediators implicated in hereditary angioedema, and elucidation of human mast cell growth factors and developmental pathways.
The Division’s home base is in the Hale Building for Transformative Medicine which features eight floors of research space, including basic, clinical and translational research labs, a Human Immunology Center, a single cell RNA-sequencing core, patient information and consent rooms for clinical trials, and an advanced imaging suite. Here MDs and PhDs work in a highly collaborative fashion. In addition to the R01-funded basic science and translational labs focused on eicosanoids, lymphocyte biology, mast cell biology, antibody generation, and respiratory epithelial cells, the group works closely with researchers doing cutting-edge clinical trials, genomic studies, database research and computational analyses across the Longwood Medical Area to speed the process from discovery from bench to bedside.