The Department of Neurosurgery at Brigham and Women's Hospital is on the forefront of neuroscience and tumor biology research. With a robust research agenda and state-of-the-art technologies, our program is supported by over 20 research faculty and $10 million in funding each year.
Our laboratories conduct both basic science and clinical research to explore a range of complex neurological diseases, such as brain tumors, spinal disorders, stroke, and epilepsy. The aim of our research is to investigate the underlying risks, treatment strategies, and outcomes associated with these diseases and translate new findings to design and optimize neurosurgical treatments for each of our patients. Our Department works collaboratively on various research projects, as well as with other local, national and international partnering institutes.
Focus: Molecular diagnosis and prognosis for clinical and surgical applications
Surgical Molecular Imaging LaboratorySee Research Profile See Nathalie Agar, PhD, Research Profile
Focus: Re-wiring of neural circuits
Focus: Translational biology of skull base tumors by integrating genomic, immunology, advanced imaging, and computational tools to improve patient and surgical outcomes
Focus: Novel experimental therapies for malignant brain tumors
Focus: Drug delivery and the blood brain barrier in brain tumors
Focus: Cancer epidemiology and statistical genetics
Focus: Role of genetics in stroke and cerebrovascular diseases
Focus: Structural and functional MRI and brain electrophysiology
Surgical Brain Mapping LaboratorySee Research Profile See Alexandra Golby, MD, Research Profile
Focus: To harness the administrative, clinical, research and financial data streams combined with detailed outcomes tracking to inform best practices and protocols for neurosurgery.
Computational Neuroscience Outcomes CenterSee Research Profile See William Gormley, MD, MPH, MBA, Research Profile
Focus: Functional recovery after spinal cord injury
Spinal Cord Injury Research LaboratorySee Research Profile See Yi Lu, MD, PhD, Research Profile
Focus: Immunotherapy and non-coding RNAs in brain tumors
Focus: Oncolytic viruses and immunotherapy in glioblastoma
Focus: The biology of small non-coding RNAs and the pioneering of their genetic engineering for a cure against brain cancer.
Focus: Applying neural engineering and neuromodulation to understand the brain and treat neurological and psychiatric diseases
Mapping & Engineering Neural Dynamics (MEND) LaboratorySee Research Profile
Focus: Develop and test novel targeted stem cell based therapies for cancer
Vice Chair for Research
Center for Stem Cell Therapeutics and Imaging
Computational Neuroscience Outcomes CenterSee Research Profile See Timothy Smith, MD, MPH, PhD, Research Profile
Focus: Developing neuroimaging approaches for presurgical brain mapping and investigation of brain function alterations in neurological conditions.
Focus: Identification of candidate therapeutics for neurodegenerative disorders
Neuroapoptosis Drug Discovery LaboratorySee Research Profile See Xin Wang, PhD, Research Profile
For over a century, a leader in patient care, medical education and research, with expertise in virtually every specialty of medicine and surgery.