DPNBM Site Investigator: Richard Parad, MD, MPH
Overall Principal Investigators: Robert Green, Alan Beggs, Project #2: Richard Parad, MD, MPH
Overall Aim: To determine whether genomic sequencing of a newborn infant confers benefit to the infant or family.
Study Population: Well newborns
Study Contact: Richard Parad, MD, MPH
DPNBM Site Investigator: Mandy Brown Belfort, MD, MPH
Overall Principal Investigator: Mandy Brown Belfort, MD, MPH
Overall Aim: To assess the nutritional content of maternal breast milk.
Study Population: Premature infants ≤32 weeks ≥ 14 days old planning to provide breast milk exclusively.
Study Contact: Mandy Brown Belfort, MD, MPH and Caroline Palmer, BS
DPNBM Site Investigator: Helen Christou, MD
Overall Principal Investigator: Janet Soul
Overall Aim: To assess the usefulness of Bumetanide treatment for seizures in newborn infants
Study Population: Newborns at postconceptual age of 33 to 44 weeks who are at risk of seizures or suspected seizures due to asphyxia/HIE, intracranial hemorrhage, suspected or confirmed stroke, CNS infection, genetic syndrome, brain malformation, metabolic disorder
Study Contact: Avantika Singh, Research Fellow
(617) 355-6369; page# 5401
DPNBM Site Investigator: Richard Parad, MD, MPH
Overall Principal Investigator: Jonathan Davis
Overall Aim: To evaluate CC10 as a potential preventive treatment for neonatal chronic lung disease (Interventional FDA orphan funded trial).Study Population: NICU Infants <29 weeks, enrolled within 4 hrs of birth
Study Contact: Richard Parad, MD, MPH, Emily Langner, MA
DPNBM Site Investigator: Anne CC (S.) Lee, MD, MPH
Overall Principal Investigator: Anne CC (S.) Lee, MD, MPH
Overall Aim: To test a newly developed method of assessing a newborn infant’s level of jaundice that can be applied in under-resourced settings.
Study Population: Well newborns
Study Contact: Anne CC (S.) Lee, MD, MPH
DPNBM Site Investigators: Brian Walsh, MD
Overall Principal Investigators: Ellen Grant , Mari Franceschini
Overall Aim: To evaluate ways to improve cerebral monitoring of the extremely preterm infant with specific focus on intermittent hypoxic episodes.
Study Population: Inclusion: Premature infants born <32 weeks and <72 hours of age or are intubated. Exclusion: Contraindication to NIRS probe to scalp, or major congenital anomaly
Study Contact: Brian Walsh
DPNBM Site Investigator: Brian Walsh, MD,
Overall Principal Investigator: Ivy Lin, Mari Franceschini
Overall Aim: To assess brain health in premature infants who have had IVH and PHH.
Study Population: Studies in 4 groups:GM/IVH, PHH, infants with ventriculomegaly, healthy control.
Study Contact: Ivy Lin
DPNBM Site Investigator: Linda Van Marter, MD, MPH
Overall Principal Investigators: Page Pennell, MD, Kimford Meador
Overall Aim: To evaluate maternal and neonatal outcomes of maternal anti-epileptic drug therapy
Study Population: Pregnant women with epilepsy and their infants
Study Contact: Linda Van Marter, MD, MPH
DPNBM Site Investigator: Sarbattama Sen, MD
Overall Principal Investigator: Sarbattama Sen, MD
Overall Aim: To determine whether the addition of prenatal vitamin supplementation will improve outcomes of obese mothers and their infants.
Study Population: Pregnant women with BMI > 30
Study Contact: Annie Penfield-Cyr, BS
DPNBM Site Investigator: Lianne Woodward, PhD
Overall Principal Investigator: Lianne Woodward, PhD
Overall Aim: Parent interview to learn more about parents’ experiences while their infant is hospitalized in the Newborn Intensive Care Unit (NICU).
Study Population: All infants and mothers with LOS > 1 week
Study Contact: Alyssa Morris, BS
DPNBM Site Investigators: Mohamed El-Dib, MD
Overall Principal Investigator: Ellen Grant
Overall Aim: To determine if an index of cerebral oxygen metabolism (CMRO2i) measured by frequency domain near infrared spectroscopy (FDNIRS) in combination with Diffuse Correlation Spectroscopy (DCS) in babies with neonatal encephalopathy will predict outcomes up to 2 years of age.
Study Population: Newborns of gestational age ≥33 weeks diagnosed with neonatal encephalopathy
Study Contact: Mohamed El-Dib, MD
DPNBM Site Investigator: Saima Aftab, MD
Overall Aim: To investigate the impact of maternal dietary supplementation with pomegranate juice on the placenta and on subsequent newborn brain development and function.
Study Population: Pregnant women between 24 weeks and 34 weeks gestation with an estimated fetal weight less than the 5th percentile on the Doubilet growth curve.
Study Contact: Stephanie Lynch, MPH, Zachary Sletterink, BA
DPNBM Site Investigator: Linda Van Marter, MD, MPH
Overall Principal Investigator: Martha Sola-Visner
Overall Aim: Mathematical modeling of prolonged and severe thrombocytopenia
Study Population: NICU infants < 42 weeks PMA with persistent thrombocytopenia > 5 days with plt <60 or receiving plt for count <100
Study Contact: Yvonne Sheldon, Linda Van Marter, MD, MPH
DPNBM Site Investigator: Linda Van Marter, MD, MPH
Overall Principal Investigators: Stella Kourembanas, MD, Linda Van Marter, MD, MPH
Overall Aim: To evaluate factors contributing to chronic lung disease and other serious complications of prematurity.
Study Population: BWH NICU infants born before 29 completed weeks of gestation
Study Contact: Linda Van Marter, MD, MPH
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