Neonatal Cardiovascular, Pulmonary and Integrated Biology Research

Our mission is to support clinical innovation in neonatal care through scientific discovery. Using preclinical models and translational approaches our physician-scientist-led research groups address biological questions important to perinatal transition, morbidities of prematurity, and long term health of our patient population. Focus areas include cardiovascular and pulmonary diseases such as bronchopulmonary dysplasia, lung injury and repair, pulmonary hypertension, congenital heart disease and cardiomyopathies, systemic disturbances such as infection, inflammation and sepsis and disorders of angiogenesis such as retinopathy of prematurity. Our approaches include studies of novel pathogenetic mechanisms such as autophagy, nutritional factors and angiogenesis, cell-based therapies and novel pharmacologic interventions.

Neonatal Cardiovascular, Pulmonary and Integrated Biology Teams

Cataltepe Lab
The Cataltepe Laboratory, led by Sule Cataltepe, MD, studies the molecular mechanisms that are involved in the development of chronic lung disease in premature infants. The lab is particularly interested in mechanisms that govern vascular growth in the lung in CLD as well as in other pathologies.

Team Members:

  • Xiaoliang Liang, PhD, Postdoctoral Fellow

Christou Lab
The Christou Laboratory, led by Helen Christou, MD, studies the mechanisms contributing to long term cardiopulmonary morbidities in surviving premature infants and developing interventions to ameliorate them. The research is focused on pulmonary hypertension and Bronchopulmonary Dysplasia.

Team Members:

  • Hannes Hudalla, PhD, Postdoctoral Fellow
  • Zoe Michael, PhD, Postdoctoral Fellow

Perrella Lab 
The Perrella Laboratory, led by Mark Perrella, MD, studies the regulation of genes important for the modulation of vascular tone, vascular cell growth, and oxidative stress in inflammatory disease processes involving the lungs and other critical organs, in addition to investigating the regulation and biology of genes selectively expressed in vascular smooth muscle cells.

Team Members:

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