Our lab specializes in research related to the renin-angiotensin-system (RAS) and hemodynamic response in various populations. Using a unique auto analyzer assay method allows us to measure kidney function through the analysis of renal plasma flow (RPF) and glomerular filtration rate (GFR). These assay methods have been paramount in the study of the human kidney. Other methods of kidney study have focused on kidney hormones and measurements of plasma renin, renin activity (PRA) prorenin, aldosterone and angiotensin II (Ang II).
Our second line of investigation involves the role of nitric oxide synthesis in the control of several regional circulations in the human and the influence of flavanoids on the state of these circulations, specifically in response to nitric oxide synthesis activation. The richest supply of plant flavanoids identified to date has come from flavanol-rich cocoa -- minimally processed. In a parallel investigation performed in Panama, we have identified a strikingly lower frequency of ischemic heart disease, stroke, diabetes mellitus, and cancer in inhabitants who ingest a very high flavanoid intake, largely cocoa. Specific foci include:
Control of the circulation of the brain, the kidney, and the extremity
Renal and hormonal response following consumption of flavanol-rich cocoa
Norman K Hollenberg, MD, PhD Director, Physiologic Research Division Department of Radiology Brigham and Women's Hospital Professor of Medicine Harvard Medical School Boston, MA 02115 Phone: (617) 732-6682