Lifestyle and Nutrition Factors
CDNM investigators have examined a wide range of lifestyle factors, including obesity, physical activity, alcohol use, hormonal and reproductive exposures, and dietary patterns and factors, with risk of ischemic, hemorrhagic, and total stroke.
Biomarkers
NIH-funded research has supported CDNM investigations of sex hormones, adipokines, fatty acids, magnesium, and vitamin D with risk of ischemic stroke.
Metabolomics
NHLBI-funded research currently supports our investigation of metabolomic signatures for ischemic stroke among women in the Nurses’ Health Studies (I and II).
Network Approaches
CDNM investigators have been using network approaches to examine metabolomic profiles using subnetworks and disease pathway models
Study Populations
Study populations utilized by CDNM investigators include:
- Nurses’ Health Study and Nurses’ Health Study II
- Health Professionals Follow-up Study
- Women’s Health Initiative
National and International Collaborations
Stroke investigators at CDNM are involved in the NINDS Stroke Genetics Network (SiGN) Study, the International Stroke Genetics Consortium, CoMETS, and NHLBI Trans-Omics in Precision Medicine (TOPMed), which facilitate access to an extensive repertoire of multi-omic data.