Systems Genetics and Genomics

The Systems Genetics and Genomics Unit (previously the Respiratory, Genetic, and Environmental Epidemiology Unit) has developed a larger number of smaller study populations in both Asthma and COPD, with a total sample size of approximately 100,000 subjects with DNA samples. For more information about each project, please refer to our complete listing of all research projects.

Channing COPD Study Populations

StudyDesignFundingSample SizeLongitudinal Follow-Up AvailableGenome-wide SNP Genotyping Available
Boston Early-Onset COPD Study (EOCOPD)Extended PedigreesNIH1,200NoNo
International COPD Genetics NetworkNuclear FamiliesGlaxoSmithKline3,100NoNo
National Emphysema Treatment Trial (NETT)CasesNIH382Yes, within surgical trialYes
Normative Aging StudyControlsNIH1,500Yes, for 30 yearsYes
Bergen, Norway COPD Study (Norway)Case-ControlGlaxoSmithKline1,629NoYes
ECLIPSECase-ControlGlaxoSmithKline1,911Yes, for 3 yearsYes
Transcontinental COPD Genetics StudyCase-ControlNIH1,000NoNo
Genetic Epidemiology of COPD (COPDGene)Case-ControlNIH10,300Yes, phone contact for 3 yearsYes

BWH/Channing Asthma Study Populations

StudyDesignFundingSample SizeLongitudinal Follow-Up AvailableGenome-wide SNP Genotyping AvailableOther Genomic Data
CAMPTriosNIH958 subjects and their parentsYesYesMethylation + gene expression of CD4 cells and immortalized lymphocytes
Costa RicaTrios + Extended PedigreesNIH200 trios and 840 extended pedigree membersNoYesPeripheral whole blood gene expression
SHARPTrios and singleton asthmaticsNIH2,000 asthmatic subjects and trios from asthma clinical trialsYesYesNo
EVE60% case-control and 40% triosNIH6,000PartialYesSee ABRIDGE
ABRIDGE50% case only and 50% triosNIH1,500 subset of EVEPartialYesGene expression and Methylation
VDAARTRandomized clinical trialNIH900 mother-infant pairsYesDNA but no GWASRNA but no gene expression yet
CrimsonCases + controlsNIH16,000Yes, with health outcomesNot YetNo
ALA Asthma Clinical trialsALA2,000YesYesNo
VIVACohort study of mothers and children at risk for asthmaNIH5,000YesDNA but no GWASPlans for DNA methylation studies
Home AllergensCohort study of mothers and children at risk for asthmaNIH1,000YesDNA but no GWASLimited gene expression data
Fetal Lung Development IssuesCohort studyNIH500NoYesGene expression
Normal ControlsCross-sectional studyNIH400NoYesYes