Systems Genetics and Genomics

The Systems Genetics and Genomics Unit (previously the Respiratory, Genetic, and Environmental Epidemiology Unit) has developed a larger number of smaller study populations in both Asthma and COPD, with a total sample size of approximately 100,000 subjects with DNA samples. For more information about each project, please refer to our complete listing of all research projects.

Channing COPD Study Populations 

Study Design Funding Sample Size Longitudinal Follow-Up Available Genome-wide SNP Genotyping Available
Boston Early-Onset COPD Study (EOCOPD) Extended Pedigrees NIH 1,200 No No
International COPD Genetics Network Nuclear Families GlaxoSmithKline 3,100 No No
National Emphysema Treatment Trial (NETT) Cases NIH 382 Yes, within surgical trail Yes
Normative Aging Study Controls NIH 1,500 Yes, for 30 years Yes
Bergen, Norway COPD Study (Norway) Case-Control GlaxoSmithKline 1,629 No Yes
ECLIPSE Case-Control GlaxoSmithKline 1,911 Yes, for 3 years Yes
Transcontinental COPD Genetics Study Case-Control NIH 1,000 No No
Genetic Epidemiology of COPD (COPDGene) Case-Control NIH 10,300 Yes, phone contact for 3 years Yes


BWH/Channing Asthma Study Populations

Study Design Funding Sample Size Longitudinal Follow-Up Available Genome-wide SNP Genotyping Available Other Genomic Data
CAMP Trios NIH 958 subjects and their parents Yes Yes Methylation + gene expression of CD4 cells and immortalized lymphocytes
Costa Rica Trios + Extended Pedigrees NIH 200 trios and 840 extended pedigree members No Yes Peripheral whole blood gene expression
SHARP Trios and singleton asthmatics NIH 2,000 asthmatic subjects and trios from asthma clinical trials Yes Yes No
EVE 60% case-control and 40% trios NIH 6,000 Partial Yes See ABRIDGE
ABRIDGE 50% case only and 50% trios NIH 1,500 subset of EVE Partial Yes Gene expression and Methylation
VDAART Randomized clinical trial NIH 900 mother-infant pairs Yes DNA but no GWAS RNA but no gene expression yet
Crimson Cases + controls NIH 16,000 Yes, with health outcomes Not Yet No
ALA Asthma Clinical trials ALA 2,000 Yes Yes No
VIVA Cohort study of mothers and children at risk for asthma NIH 5,000 Yes DNA but no GWAS Plans for DNA methylation studies
Home Allergens Cohort study of mothers and children at risk for asthma NIH 1,000 Yes DNA but no GWAS Limited gene expression data
Fetal Lung Development Issues Cohort study NIH 500 No Yes Gene expression
Normal Controls Cross-sectional study NIH 400 No Yes Yes