The Genetics & Genomic Medicine Service at Brigham and Women’s Hospital provides care for individuals in need of genetic risk assessment, genetic testing, genetic diagnosis, genetic counseling, or management of genetic disease. We offer exome and genome sequencing as a clinical service to patients for diagnosis and clinical management. For more information, please visit our website.
The Division of Genetics has developed many useful software tools. Here are some of our more popular programs:
Sunyaev Lab/Bork Group
Polymorphism Phenotyping This program may be used to predict the impact of an amino acid substitution on the structure and function of a protein using straightforward physical and comparative considerations.
This program evaluates the likelihood that a given genomic region is a cisregulatory module for an input set of transcription factors according to its degree of: (1) homotypic site clustering; (2) heterotypic site clustering; and (3) evolutionary conservation across multiple genomes.
This software performs automated motif searching using four different profile-based motif finders, including AlignACE, MDscan, BioProspector and MEME. We anticipated that using all four of these motif finders might allow the user to combine the strengths of their different algorithms.