Moody Lab Publications

Madigan CA, Cheng TY, Layre E, Young DC, McConnell M, Debono CA Murry JP, Wei J-R, Barry III CE, Rodriguez GM, Matsunaga I, Rubin EJ, Moody DB.  Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in M. tuberculosis. Proc Natl Acad Sci 2012 (in press).

Layre E, Hong S, Sweet L, Madigan CA, Desjardins D, Young D, Cheng TY, Annand JW, Kim K, Shamputa IC, McConnell MJ, Debono CA, Behar SM, Minnaard AJ, Murray M, Barry III CE, Matsunaga I, Moody DB. A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis. Chem Biol2011 Dec 23; 18(12):1537-49.

Huang S, Cheng TY, Young D, Layre E, Madigan C, Shires J, Cerundolo V, Altman JD, Moody DB. Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among the diverse groove blocking lipids of the human CD1 system. Proc Natl Acad Sci 2011 Nov 29; 108(48):19335-40.  PMC3228429

Kasmar AG, van Rhijn I, Cheng T-Y, Turner M, Seshadri C, Schiefner A, Kalathur RC, Annand JW, de Jong A, Shires J, Leon L, Brenner M, Wilson IA, Altman JD, Moody DB.  CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med 2011 Aug 29; 208(9):1741-7. PMC3171094

Yakimchuk K, Roura-Mir C, Magalhaes KG, de Jong A, Kasmar AG, Granter SR, Budd R, Steere A, Pena-Cruz V, Kirschning C, Cheng TY, Moody DB. Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1-b. Eur J Immunol 2011 Mar;41(3):694-705.  PMC3082368

de Jong A, Peña-Cruz V, Cheng TY, Clark RA, Van Rhijn I, Moody DB. CD1a-autoreactive T cells are a normal component of the human ab T cell repertoire. Nat Immunol 2010 Dec;11(12):1102-9.  PMC3131223

Relloso M, Cheng TY, Im JS, Parisini E, Roura-Mir C, DeBono C, Zajonc DM, Murga LF, Ondrechen MJ, Wilson IA, Porcelli SA, Moody DB. pH-dependent interdomain tethers of CD1b regulate its antigen capture. Immunity 2008; 28(6):774-86.  PMC2753602

de Jong A, Arce EC, Cheng TY, van Summeren RP, Feringa  BL, Dudkin V, Crich D, Matsunaga I, Minnaard AJ, Moody DB. CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs. Chem Biol 2007; 14(11):1232-42.  PMC2692252

Moody DB. Immunology: how a T cell sees sugar. Nature 2007; 448(7149):36-7.

Cheng T, Relloso M, Van Rhijn I, Young DC, Besra G, Briken V, Zajonc D, Wilson IA, Porcelli S, Moody DB. Role of lipid trimming and CD1 groove size in cellular antigen presentation. EMBO J 2006; 25:2989-99.  PMC1500985

Moody DB. TLR gateways to CD1 function. Nat Immunol 2006; 7(8):811-7.

Roura-Mir C, Wang L, Cheng TY, Matsunaga I, Dascher CC, Peng SL, Fenton MJ, Kirschning C, Moody DB. Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J Immunol2005; 175(3):1758-66.

Roura-Mir C, Catalfamo M, Cheng TY, Marqusee E, Besra GS, Jaraquemada D, Moody DB. CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis. J Immunol 2005; 174(6):3773-80.

Zajonc DM, Crispin MD, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, Brenner MB, Moody DB, Wilson IA.  Molecular mechanism of lipopeptide presentation by CD1a.  Immunity 2005; 22(2):209-19.

Matsunaga I, Bhatt A, Young DC, Cheng TY, Eyles SJ, Besra GS, Briken V, Porcelli SA, Costello CE, Jacobs WR, Moody DB. Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J Exp Med 2004; 200(12):1559-69.

Van Rhijn I, Young DC, Im JS, Levery SB, Illarionov  PA, Besra GS, Porcelli SA, Gumperz J, Cheng TY, Moody DB. CD1d-restricted T cell activation by nonlipidic small molecules. Proc Natl Acad Sci U S A2004; 101(37):13578-83.

Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O'Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA, Costello CE, Brenner MB. T cell activation by lipopeptide antigens. Science 2004; 303(5657):527-31.