Identifying Early Biomarkers of Alzheimer's Disease Trial

Identifying Early Biomarkers of Alzheimer's Disease

Full Study Title:
  Evolution of memory-related fMRI activation over the course of MCI and AD

What is the purpose of this study?

The purpose of this study is to explore the usefulness of fMRI as a biomarker (a way to detect a disease) for use in clinical drug studies and studies of disease progression in people with mild memory impairments (MCI), an early stage of memory loss and Alzheimer’s disease (AD). This study will help us find out if there are changes in the fMRI scan that occur over the course of MCI and mild AD. We will examine the relationship of fMRI scan findings to clinical variables, memory task performance, gene type, and other imaging techniques (ASL perfusion and volumetric MRI) in those who have had scans at one time point (cross-sectionally) and those who will have several scans over 36 months (longitudinally).

Who is eligible?

We are looking for participants who:

* are between the age of 55 and 90 
* are in general good health or have stable medical problems at the time of screening 
* have a study partner/caregiver able to provide an independent evaluation of daily functioning 
* have no contraindications to MRI scanning
* are in stable medical condition

People with significant neurological diseases other than Alzheimer’s disease or memory impairment are ineligible. For more detailed information about eligibility for this study, please contact us.

What happens during the study?

During the study, we will ask you to come to our office to have blood drawn, undergo tests of memory and have an MRI scan of the brain.

How long is this study?

This study requires 8 clinic visits over the course of 3 years. Each study visit will last for 3 to 5 hours.

Will I be paid?

Study participants will be reimbursed $50.00 for the completion of each scan visit and $50 for each testing visit. We will also pay the costs of parking at our offices during your visits.

Who is sponsoring this study?

National Institute on Aging

How do I find out more about the study?

For more information, please call us at 617-732-8085 or email our study coordinator Natacha Lorius