Representative Publications

  1. Quintana, F.J., Hagedorn, P.H., Elizur, G., Merbl, Y., Domany, E. & Cohen, I.R. Functional immunomics: microarray analysis of IgG autoantibody repertoires predicts the future response of mice to induced diabetes. Proc Natl Acad Sci U S A 101, 14615-14621 (2004).
  2. Quintana, F.J., Gerber, D., Kent, S.C., Cohen, I.R. & Shai, Y. HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. J Clin Invest 115, 2149-2158 (2005). 
  3. Quintana, F.J., Basso, A.S., Iglesias, A.H., Korn, T., Farez, M.F., Bettelli, E., Caccamo, M., Oukka, M. & Weiner, H.L. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453, 65-71 (2008).
  4. Quintana, F.J., Farez, M.F., Viglietta, V., Iglesias, A.H., Merbl, Y., Izquierdo, G., Lucas, M., Basso, A.S., Khoury, S.J., Lucchinetti, C.F., Cohen, I.R. & Weiner, H.L. Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc Natl Acad Sci U S A 105, 18889-18894 (2008).
  5. *Farez, M.F., *Quintana, F.J., Gandhi, R., Izquierdo, G., Lucas, M. & Weiner, H.L. Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nat Immunol 10, 958-964 (2009).
  6. *Apetoh L., *Quintana F.J., *Pot C., Joller N., Xiao S., Kumar D., Burns E.J., Sherr D.H., Weiner H.L. and Kuchroo V.K.. The Aryl hydrocarbon Receptor (AhR) interacts with c-Maf to promote the differentiation of IL-27-induced regulatory type 1 (TR1) cells. Nat Immunol 11, 854-61 (2010).
  7. Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., Kozoriz D., Weiner H.L. and Quintana F.J.. Aryl hydrocarbon receptor activation induces human Tr1-like and Foxp3+ Treg cells. Nat Immunol 11, 846-53 (2010). Corresponding author.
  8. Quintana F.J., Murugaiyan G., Farez M.F., Mitsdoerffer M., Tukpah A.M., Burns E.J., Weiner H.L. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 107, 20768-73 (2010). Corresponding author.
  9. Yeste, A., Nadeau, M., Burns, E.J., Weiner, H.L., Quintana, F.J. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 109, 11270-5 (2012).
  10. *Quintana, F.J., *Jin, H., Burns, E.J., Nadeau, M., Yeste, A., Kumar, D., Rangachari, M., Zhu, C., Xiao, S., Seavitt, J., Georgopoulos, K., Kuchroo, V.K. Aiolos promotes T(H)17 differentiation by directly silencing Il2 expression. Nat Immunol 13, 770-7 (2012).
  11. Mascanfroni, I.D., Yeste, A., Vieira, S.M., Burns, E.J., Patel, B., Sloma, I., Wu, Y., Mayo, L., Efroni, S., Kuchroo, V.K., Robson, S.C. and Quintana, F.J.. IL-27 acts on dendritic cells to suppress the T-cell response and autoimmunity by inducing ENTPD1 (CD39) expression. Nat Immunol. 14, 1054-63 (2013).
  12. Yeste, A., Mascanfroni, I.D., Nadeau, M., Burns, E.J., Tukpah, A.M., Santiago, A., Wu, C., Patel, B., Kumar, D., Quintana, F.J.. IL-21 induces STAT3-mediated CD4+ T-cell production of IL-22. Nat Commun. 5, 3753 (2014). 
  13. Mayo L., Trauger S.A., Blain M., Nadeau M., Patel B., Alvarez J.I., Mascanfroni I.D., Yeste A., Kivisäkk P., Kallas K., Ellezam B., Bakshi R., Prat A., Antel J.P., Weiner H.L., Quintana F.J.. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 20, 1147-56 (2014).
  14. Mascanfroni I.D., Takenaka M.C., Yeste A., Patel B., Wu Y., Kenison J., Siddiqui S., Basso A.S., Otterbein L.E., Pardoll D.M., Pan F., Priel A., Clish C.B., Robson S.C., Quintana F.J.. Metabolic control of type 1 regulatory (Tr1) cell differentiation by AHR and HIF1-α. Nat Med. 21, 638-46 (2015).
  15. Farez M.F., Mascanfroni I.D., Mendez-Huergo S.P., Yeste A., Gopal M., Garro L., Balbuena Aguirre M.E., Patel B., Ysrraelit M.C., Zhu C., Kuchroo V.K., Rabinovich G.A., Quintana F.J.*, Correale J.*. Melatonin Contributes To The Seasonality Of Multiple Sclerosis Relapses. Cell 162, 1338-52 (2015). *co-senior authors. Corresponding author.
  16. Yeste A., Takenaka M.C., Mascanfroni I.D., Nadeau M., Kenison J.E., Patel B., Tukpah A-M, Babon J.A.B., DeNicola M., Kent S.C., Pozo D., Quintana F.J.. Induction of SOCS2 by tolerogenic nanoparticles arrests the diabetogenic T cell response. Science Signaling 9, ra61 (2016)
  17. Covacu R., Philip H., Jaronen M., Almeida J., Kenison J., Darko S., Chao C.C., Douek D.C., Efroni S. and Quintana F.J.. System-wide analysis of the T-cell response. Cell Reports. 14, 2733-44 (2016)
  18. Goettel J.A., Gandhi R., Kenison J.E., Yeste A., Murugaiyan G., Sambanthamoorthy S., Griffith A.E., Patel B., Shouval D.S., Weiner H.L., Snapper S.B., Quintana F.J.. AHR activation is protective against colitis driven by T cells in humanized mice. Cell Reports. 17(5):1318-1329 (2016) 
  19. Rothhammer R., Mascanfroni I.D., Bunse L., Takenaka M.C., Kenison J., Mayo L., Chao C.C., Patel B., Yan R., Blain M., Alvarez J.I., Kébir H., Anandasabapathy N., Izquierdo G., Jung S., Obholzer N., Pochet N., Clish C.B., Prinz M., Prat A., Antel J., Quintana F.J. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat. Med. 22, 586-97 (2016)
  20. Rothhammer R., Kenison J., Tjon E., Takenaka M., Alves De Lima K., Borucki D., Chao C., Wilz A., Blain M., Healy L., Antel J., Quintana F.J. Sphingosin-1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation. Proc Natl Acad Sci U S A.  114, 2012-2017 (2017)

See full list of publications.