Otolaryngology-Head and Neck Surgery Research

Otolaryngology faculty members are committed to fulfilling Brigham and Women’s Hospital’s (BWH) important research mission. Our faculty contribute to the advancement of otolaryngology knowledge and innovations in diagnosis, medical treatment and surgical techniques for common, rare and complex diseases of the ears, nose and throat regions.

Our otolaryngologists are also at the forefront of improving the quality and effectiveness of healthcare. National leaders and collaborators with others at institutions and medical societies, our faculty investigates, develops and publishes clinical guidelines and population studies that influence and improve the quality of care for all patients.

Current Research

Below is a brief summary of the faculty’s recent research work and scholarly contributions.

Thomas L. Carroll, MD

  • Dr. Carroll’s research studies two clinical diagnoses that are often inconclusive: laryngopharyngeal reflux (LPR) and glottic insufficiency. Both can present with similar symptoms but are managed in completely different ways.
  • He also explores alternate dosing regimens for acid suppressive medications for laryngopharyngeal reflux (LPR) and will be exploring the role of vocal fold augmentation for patients with Parkinson’s disease as part of a prospective multicenter clinical trial.
  • Dr. Carroll is an instructor in otology and laryngology at Harvard Medical School.

Carleton Eduardo Corrales, MD

  • Dr. Corrales researches the degeneration and regeneration processes of the inner ear thru functional assessment assays viewed in an in vivo manner. Micro-endoscopy using gradient refractive index optics (GRIN) offers a new approach to overcome this challenge. GRIN micro endoscopy is an emerging imaging modality that provides micron-scale optical resolution in tissues inaccessible to standard light microscopy.
  • He also investigates cochlear GRIN micro endoscopy to provide a greater understanding of cochlear microanatomy in order to provide a step-by-step roadmap of ototoxin entry to identify the cellular changes occurring in hair cells after, for example, aminoglycoside exposure. Even more important, it will identify intervention sites for hearing preservation during ototoxic events and will provide novel assays for efficacy of intervention regardless of the hearing loss type (aminoglycoside-induced, noise-induced, age-related or cisplatin-induced).
  • Dr. Corrales is an instructor of otology and laryngology at Harvard Medical School.

Laura A. Goguen, MD, FACS

  • Dr. Goguen’s research focuses on neck dissection and dysphagia management in head and neck cancer. Her work on these subjects has been published in several peer-reviewed journals in otolaryngology.
  • She is also involved in the development of several cancer treatment protocols in collaboration with her colleagues in the Dana-Farber Brigham Cancer Center.
  • She has authored over 30 peer-reviewed publications in otolaryngology and her research has been disseminated at regional and national presentations.
  • Dr. Goguen is an Associate Professor of otology and laryngology at Harvard Medical School.

Anthony Prince, MD

  • Dr. Prince’s research centers on patient safety and quality improvement in otolaryngology. He currently serves as a member of the Department of Surgery Quality Improvement Committee.
  • He also has interests in global health and in particular expanding access to otolaryngologic care in resource-poor settings outside the U.S. He has previously served as a volunteer in Cange, Haiti through Partners in Health.
  • Dr. Prince is an Instructor of otology and laryngology at Harvard Medical School.

Jennifer Shin, MD, SM

  • Dr. Shin is the chair of the Outcomes Research and Evidence-Based Medicine Leadership Group for the American Academy of Otolaryngology-Head and Neck Surgery Foundation. She has also recently served as co-chair of the expert panel convened by the Academy to develop their national Clinical Consensus Statement on Pediatric Chronic Rhinosinusitis and is currently vice-chair of the upcoming national Clinical Practice Guideline on Otitis Media with Effusion.
  • She serves as associate editor for clinical epidemiology and outcomes research for the Journal, Otolaryngology-Head and Neck Surgery.
  • Dr. Shin has authored over 50 peer-reviewed research papers and two textbooks in otolaryngology. Her first book, Evidence-Based Otolaryngology, was counted as among the publisher’s most accessed books in the field last year. Her second book, Otolaryngology Prep and Practice prepares specialists for the board certification examinations.
  • Recent years’ journal publications have spanned the range of otolaryngology topics, including hearing loss, rhinosinusitis, vascular malformations, thyroid disease, neural monitoring, and evidence-based medicine.
  • Dr. Shin is an Assistant Professor of otology and laryngology at Harvard Medical School. She teaches regularly in the epidemiology curriculum at the Harvard School of Public Health and has received multiple awards and grants, including a Harvard Medical School Shore Foundation Faculty

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