Jill M. Goldstein, PhD

Jill M. Goldstein, PhD

Jill M. Goldstein, PhD

Women's Health

Director of Research for the Connors Center for Women's Health and Gender Biology, Division of Women's Health

Jill M. Goldstein, PhD is a Professor of Psychiatry and Medicine at Harvard Medical School, a Senior Scientist with the Division of Women's Health at BWH and a Senior Scientist in the Department of Psychiatry at Massachusetts General Hospital.

As a clinical neuroscientist with doctoral training in psychiatric epidemiology and psychopathology at Columbia University, and post-doctoral training in clinical neuroscience and brain imaging at Harvard Medical School, Dr. Goldstein is an internationally recognized expert in understanding sex differences in health and diseases associated with the central nervous system. Specifically, Dr. Goldstein’s investigations have focused on characterizing sex differences in the development and adult functioning of the human brain and how these differences contribute to understanding sex differences in psychiatric and neurologic disorders and their comorbidity with general medical disorders.

Her program of research, called the Clinical Neuroscience Laboratory of Sex Differences in the Brain consists of an interdisciplinary team of investigators, integrating structural and functional brain imaging studies, psychophysiology, neuroendocrine studies of hormones and brain function, genetics, inflammatory factors, and collaborative efforts with animal investigators studying genes, hormones, inflammation and the brain. Brain circuitries under current investigation include the stress response circuitry, memory and working memory (including brain aging), and reward circuitry implicated in the neural control of obesity. This work has been funded by the National Institutes of Health for nearly 30 years. She has published over 120 articles, chapters and other original and peer-reviewed work in these areas.

Dr. Goldstein is also an administrative and educational leader in women’s health and sex differences in medicine, locally and nationally. At BWH, she has built a unique research infrastructure to foster collaborative efforts to understand mechanisms that explain sex differences in health and disease across disciplines and methods of study. She also is the Principal Investigator of a Harvard-wide junior faculty training program on building interdisciplinary careers in women’s health called, "Hormones and Genes in Women’s Health: From Bench to Bedside" and is committed to training the next generation in this arena in medicine.

Selected Publications

Goldstein, JM, Buka, SL, Seidman, LJ, Tsuang, MT.  Specificity of the transmission of schizophrenia psychosis spectrum and affective psychoses in the New England Family Studies high risk design. Archives of General Psychiatry 2010; 67:458-467. PMID: 20439827. PMCID: PMC3049996.

Goldstein, JM, Jerram, M, Abbs, B, Whitfield-Gabrieli, S, Makris, N.  Sex differences in stress response circuitry activation dependent on female hormonal cycle. Journal of Neuroscience 2010, 30 (2): 431-438. PMID: 20071507. PMCID: PMC2827936.

Goldstein, JM, Cherkerzian, S, Seidman, LJ, Petryshen, TL, Fitzmaurice, G, Tsuang, MT, Buka, SL. Sex-specific rates of transmission of psychosis in The New England High-Risk Family Study. Schizophr Res. 2011 May; 128 (1-3):150-5. PMCID: PMC3085650

Goldstein JM, Cherkerzian S, Buka S, Fitzmaurice G, Susser E, Hornig M, Gillman M, Factor-Litvak P, Sloan RP.  Sex-specific impact of maternal-fetal risk factors on depression and cardiovascular risk 40 years later. Journal of Developmental Origins of Health and Disease 2011; 2 (6): 353–364. PMCID: PMC3558934

Abbs B, Liang L, Makris N, Tsuang M, Seidman LJ, Goldstein JM. Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical. NeuroImage 2011; 56(4):1865-74;  PMCID: PMC3113542

Makris N, Swaab DF, van der Kouwe A, Abbs B, Boriel D, Handa R, Tobet S, Goldstein JM. Volumetric Parcellation Methodology of the Human Hypothalamus in Neuroimaging: Normative Data and Sex Differences. NeuroImage. 2013 April 1 (69):1-10. PMCID: PMC3575213

Holsen LM, Lancaster K, Klibanski A, Whitfield-Gabrieli S, Cherkerzian, S, Buka S, Goldstein JM. HPA-Axis Hormone Modulation of Stress Response Circuitry Activity in Women with Remitted Major Depression. Neuroscience. 2013 Oct 10; 250:733-42. PMCID: PMC3772711

Goldstein, JM, Handa, RJ, Tobet, SA. Disruption of Fetal Hormonal Programming (Prenatal Stress) Implicates Shared Risk for Sex Differences in Depression and Cardiovascular Disease. Front Neuroendocrin. 2014; 35(1); 140-158. PMCID: PMC3917309

Jacobs EG, Holsen LM, Lancaster K, Makris N, Whitfield-Gabrieli S, Remington A, Weiss B, Buka S, Klibanski A, Goldstein JM. 17β-Estradiol Differentially Regulates Stress Circuitry Activity in Healthy and Depressed Women. Neuropsychopharmacology. 2014 Aug 12. doi: 10.1038/npp.2014.203. [Epub ahead of print] PMID: 25113601. PMCID: PMC4289944

Goldstein JM, Cherkerzian S, Seidman LJ, Donatelli JA, Remington AG, Tsuang MT, Hornig M, Buka SL. Prenatal maternal immune disruption and sex-dependent risk for psychoses. Psychol Med. 2014 Nov;44(15):3249-61. PMID: 25065485. PMCID: PMC4477534

Goldstein JM, Lancaster K, Longenecker JM, Abbs B, Holsen LM, Cherkerzian S, Whitfield-Gabrieli S, Makris N, Tsuang MT, Buka SL, Seidman LJ, Klibanski A. Sex differences, hormones, and fMRI stress response circuitry deficits in psychoses. Psychiatry Res. 2015 Mar 31. pii: S0925-4927(15)00066-9. PMID: 25914141. PMCID: PMC4439265

Holsen LM, Lee J-H, Spaeth SB, Ogden LA, Klibanski A, Whitfield-Gabrieli S, Sloan RP, Goldstein JM. Brain hypoactivation, autonomic nervous system dysregulation, and gonadal hormones in depression: a preliminary study. Neurosci Lett. 2012 Apr 11;514(1):57-61.

Research and Lab Links

Building Interdisciplinary Research Careers in Women's Health (BIRCWH)

Clinical Neuroscience Lab of Sex Differences in the Brain

Connors-BRI Center for Research on Women's Health & Gender Biology

Harvard Medical School, Department of Psychiatry

Specialized Center of Research on Sex Differences in Depression (SCOR)

Contact Information

Jill M. Goldstein, PhD
jill_goldstein@hms.harvard.edu

Brigham and Women's Hospital
One Brigham Circle (OBC3-34)
1620 Tremont Street
Boston, MA 02120

Assistant: Michelle Shafer
mshafer@bwh.harvard.edu

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