E. Antonio Chiocca, MD, PhD, FAANS Neurosurgeon-in-Chief and Chairman, Department of Neurosurgery
Lab Contact Information
Harvey W. Cushing Professor of Neurosurgery, Harvard Medical School Neurosurgeon-in-Chief and Chairman, Department of Neurosurgery Co-Director, Institute for the Neurosciences Brigham and Women's Faulkner Hospital Surgical Director, Center for Neuro-oncology, Dana-Farber Cancer Institute
75 Francis Street, Boston, MA 02115 Phone: (617) 732-6939 Fax: (617) 734-8342
My laboratory is focused on developing novel genetic therapies for malignant brain tumors. A major focus of our research is the engineering of viruses that can kill tumor cells without affecting normal brain cells. We are currently combining this research with novel pharmacological and immunotherapeutic approaches for brain cancer.
Preclinical evaluation of oncolytic viruses for glioma therapy: This project focuses on the development of a recombinant Herpes virus that specifically kills brain cancer cells and is being prepared for clinical studies.
Gene, viral, and immuno- therapy of brain tumors: This project studies how to circumvent the host responses that limit the efficacy of novel engineered viruses that target gliomas as well as how to stimulate the antitumor immune response.
Novel anti-invasive and anti-angiogenic drugs for gliomas: This study focuses on understanding the molecular mechanisms of a novel class of inhibitors, called indirubins, which reduce tumor growth and dispersion in the brain.