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Anesthesiology, Perioperative and Pain Medicine Research

A Message from the Vice Chairman for Research

J. Danny Muehlschlegel, MDWelcome to the research home of the Brigham and Women's Department of Anesthesiology, Perioperative, and Pain Medicine. The Department is involved in laboratory, translational, and clinical research at the forefront of academic medicine.

The mission of our research is to understand the mechanisms of diseases and processes that we actively manage and potentially prevent in our patients as they undergo surgeries and other operative procedures. Our aim is to apply this knowledge to the development of new and more effective treatments which can be applied to the clinical practice of anesthesia, intensive care, and pain management, but also to medicine more broadly.

Research in the Department is funded through grants from the National Institutes of Health, Foundations, and Industry and is conducted by both basic scientists and by clinical anesthesiologists. Areas of basic, translational, and clinical research include a broad array of topics, reflecting the diversity, complexity, and reach of the science of Anesthesiology. Departmental investigators frequently collaborate with researchers in other Departments catalyzing the rich scientific environment of Harvard Medical School and its associated hospitals and institutions, and benefit from the longstanding tradition and infrastructure of strong clinical research at Brigham and Women’s Hospital. Fruitful collaborations between industry and departmental investigators, both in the lab and in the operating room have facilitated a strong translational pathway for the development of new drugs and procedures.

Residents and Fellows with interest in laboratory and clinical research are encouraged to pursue their own ideas within the context of our Department's world-renowned research activities and contribute importantly to the success and dissemination of these innovative translational discoveries. To quote our former Chairman Professor Simon Gelman, “Researching, or looking for answers, is unbelievably fun. To make a discovery, no matter how small, is to stand on the top of a mountain, to have a feeling that nobody in the world ever had his or her feet on that mountain. To be a pioneer and a discoverer is an amazing reward in life.”

I encourage you to explore the profiles of the various researchers to fully appreciate the breadth and commitment of our research mission across the Department.

Danny Muehlschlegel, MD, MMSc, FAHA

Vice Chairman for Research
Brigham and Women’s Hospital
Associate Professor of Anesthesiology
Harvard Medical School

Please click here to visit our New Research Website!


Researchers (in alphabetical order):

Alexander Arriaga, MD, MPH, PhD

Alexander Arriaga, MD, MPH, PhD

  • Health services research in crisis management, patient safety, perioperative care, and quality improvement, with a focus on the fields of surgery and anesthesiology

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Angela Bader, MD, MPH

Angela Bader, MD, MPH

  • Co-leads the SHARPP research group with Dr. Zara Cooper at the is at the Center for Surgery and Public Health

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Christopher W. Connor, MD, PhD

Christopher W. Connor, MD, PhD

  • Action of volatile anesthetic gases on neural circuits

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Gregory Crosby, MD

Gregory Crosby, MD

  • The impact of anesthesia and surgery on the vulnerable aged brain

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Robert R. Edwards, PhD

Robert R. Edwards, PhD

  • Biobehavioral Aspects of Acute and Chronic Pain
  • Impact of Pain-related Catastrophizing on Neuroendocrine and Inflammatory Responses to Pain

More... 
Michaela Farber, MD

Michaela Farber, MD

  • Postpartum Hemorrhage
  • Patient Safety: Establishing Unit Directives and Readiness for Crisis Management
  • Labor Epidural Education: Consent, Teaching Tools, and Minimizing the Risk of Complications

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Robert Jamison, PhD

Robert N. Jamison, PhD

  • Psychological Predictors of Chronic Pain
  • Risk Assessment for Misuse of Opioids
  • Role of Innovative Technology in Assessment and Treatment of Pain

More... 
Nitin Joshi, PhD

Nitin Joshi, PhD

  • Working at the interface of chemistry, material science, biology, and medicine, our highly interdisciplinary and collaborative research focuses on solving medical problems across a wide range of diseases, including arthritis, HIV, lung inflammation, and brain related disorders

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Jeff Karp, PhD

Jeff Karp, PhD

  • Drug delivery, medical devices, stem cell therapeutics, and tissue adhesives

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Vesela Kovacheva, MD

Vesela Kovacheva, MD

  • Utilizing big data, genetics, and artificial intelligence approaches to personalize disease management and drug administration during pregnancy

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Yuhan Lee, PhD

Yuhan Lee, PhD

  • Identifying the clinical and therapeutic unmet needs and to find solutions through biomaterials approach in collaboration with outstanding scientists and clinicians

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Philipp Lirk, MD, PhD

Philipp Lirk, MD, PhD

  • Evidence-based and Procedure-specific Acute Pain Management guidelines

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J. Danny Muehlschlegel, MD, MSc

J. Danny Muehlschlegel, MD, MSc

  • Genomics of myocardial injury in humans
  • Genetics of Atrial Fibrillation
  • Genetics of Rheumatic Heart Disease

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Srdjan Nedeljkovic, MD

Srdjan Nedeljkovic, MD

  • Innovative pain therapeutics
  • Digital health therapeutics
  • Cannabinoids for cancer pain
  • Novel hypnotics, sedatives, and anxiolytics

More... 
Christine Sang, MD, MPH

Christine Sang, MD, MPH

  • Randomized controlled clinical trials designed and conducted by Dr. Christine Sang and her group typically incorporate strategies to understand mechanisms of action and infer effects on relevant targets
  • Phenotypic screening and the development of clinical outcome assessments and potential biomarkers are approaches that are incorporated in their trials; these are particularly important in heterogeneous chronic painful conditions such as central neuropathic pain (CNP) following spinal cord injury (SCI)

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Kristin Schreiber, MD, PhD

Kristin Schreiber, MD, PhD

  • Prediction and Prevention of Postsurgical Pain
  • Evaluating Alternative Analgesic Techniques to Opioids
  • Investigation of Pain Processing Mechanisms

More... 
Charles N. Serhan, PhD, DSc

Charles N. Serhan, PhD, DSc

  • Structural elucidation of novel bioactive molecules for inflammation
  • Pro-resolving therapeutics

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Jinjun Shi, PhD

Jinjun Shi, PhD

  • Systemic delivery of siRNA, mRNA, and protein therapeutics
  • Stimuli-responsive nanomaterials for controlled delivery, photothermal therapy, and imaging
  • Bioinspired polymers for antioxidative and anti-inflammatory therapy
  • Synthetic vaccine nanotechnologies

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Mieke Soens, MD

Mieke Soens, MD

  • Elucidating the mechanisms that drive the transition from acute pain after surgery to persistent postsurgical pain

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Matthew Spite, PhD

Matthew Spite, PhD

  • Role of lipid mediators in inflammation

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Wei Tao, PhD

Wei Tao, PhD

  • Biomaterials
  • RNA Therapeutics
  • Drug Delivery
  • Biomedical Engineering
  • Nanomedicine

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Richard Urman, MD, MBA

Richard Urman, MD, MBA

  • Clinical Trials of New Drugs and Devices
  • Informatics and Database Tools
  • Patient Safety Research
  • Opioid-related Complications

More... 
Jie Zhou, MD, MS, MBA, FASA

Jie Zhou, MD, MS, MBA, FASA

  • Obstetric Anesthesia
  • Neuro Anesthesia
  • Obstetrics-Related Neurological and Neurosurgical Conditions

More... 

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