FISH Tests On Solid Tumors
| Disease |
Chromosome |
Diagnostic |
Control
|
Location |
| |
Aberration |
Probe |
Probe
|
|
| SOFT TISSUE TUMORS |
|
|
|
|
| Low grade fibromyxoid sarcoma |
|
|
|
|
|
t(7;16)(q34;p11) |
FUS |
|
16p11 |
| Inflammatory myofibroblastic |
|
|
|
|
|
t(2p23) |
ALK |
|
2p23 |
| Ewing’ sarcoma/PNET* |
|
|
|
|
|
t(11:22)(q24;q12)/t(22q12) |
EWSR1 |
|
22q12 |
| Ewing’ sarcoma/PNET* |
|
|
|
|
|
t(11:22)(q23;q12)/t(22q12) |
EWSR1 |
|
22q12 |
|
Extraskeletal myxoid chondrosarcoma
|
|
|
|
|
|
t(9;22) (q22-24;q12) |
EWSR1 |
|
22q12 |
| Clear cell sarcoma |
|
|
|
|
|
t(12;22)(q13;q12) |
EWSR1 |
|
22q12 |
|
t(2;22)(q33;q12) |
|
|
|
| Desmoplastic small round cell* |
|
|
|
|
|
t(11;22)(p13;q12) |
EWSR1 |
|
22q12 |
| Synovial sarcoma |
|
|
|
|
|
t(X;18)(p11;q11) |
SYT |
|
18q11.2 |
| Myxoid liposarcoma |
|
|
|
|
|
t(12;16)(q13;p11) |
CHOP |
|
12q13
|
|
|
or (FUS) |
|
16p11 |
|
Infantile fibrosarcoma Congenital mesoblastic nephroma
|
|
|
|
|
|
t(12;15)(p13;q26) |
ETV6 |
|
12p13 |
| Alveolar rhabdomyosarcoma* |
|
|
|
|
|
t(1;13)(p36;q14),t(2;13)(q35;q14 |
FKHR |
|
13q14 |
|
Angiomatoid fibrous
histiocytoma
|
t(12;16)(q13;11
t(12;22)(q13;12)/t(2;22)(q34;q12) |
FUS
EWSR1
|
|
16p11
22q12
|
|
|
Well-Differentiated Liposarcoma
|
|
|
|
|
|
Amp(12q15) |
HMGA2 |
|
12q15 |
| Rhabdoid tumor |
|
|
|
|
|
del(22q) |
EWSR1 |
|
22q12 |
|
|
BCR/ABL |
|
22q11.2/9q34 |
| Endometrial Stroma Sarcoma |
|
|
|
|
|
t(7;17)(p15;q21) |
JAZF1 |
|
7p15 |
|
t(6;7) (p21;p15) |
|
|
|
| Neuroblastoma* |
|
|
|
|
|
amp(MYCN) |
MYC N |
|
2p24.1 |
|
del(1p) |
LSI1p36 |
|
1p36 |
|
|
|
LSI1q25 |
1q25 |
|
del(11q) |
MLL |
|
11q23 |
| Lipoma |
|
|
|
|
|
t(12q13-15) |
HMGA2 |
|
12q15 |
| *small blue round cell tumors |
|
|
|
|
|
|
|
|
|
| BRAIN TUMORS |
|
|
|
|
| Oligodendroglioma |
|
|
|
|
|
del(1p) |
LSI1p36 |
|
1p36 |
|
|
|
LSI1q25 |
1q25 |
|
del(19q) |
LSI19q13 |
|
19q13 |
|
|
|
LSI19p13 |
19q13 |
| Medulloblastoma |
|
|
|
|
|
i(17)(q10) |
LIS1 |
|
17p13.3 |
|
|
RARA |
|
17q21.1 |
|
|
|
|
|
| KIDNEY TUMORS |
|
|
|
|
|
|
|
|
|
| Renal cell carcinoma |
|
|
|
|
|
Papillary
|
|
|
|
|
|
Trisomy 7, Trisomy 17 |
D7Z1 |
|
7p11.1-q11.1 |
|
|
D17Z1 |
|
17p11.1-q11.1 |
| Chromophobe |
|
|
|
|
|
Disomy 7, Monosomy 17 |
D7Z1 |
|
7p11.1-q11.1 |
|
Monosomy 1 |
D17Z1 |
|
17p11.1-q11.1 |
|
|
D1Z1 |
|
1p11.1-q11.1 |
|
|
|
|
|
| OTHER TUMORS |
|
|
|
|
|
|
|
|
|
| Mesothelioma |
|
|
|
|
|
del(9p) |
LSI p16 |
|
9p21 |
|
|
|
9cen |
9p11.1-q11.1 |
|
del(22q) |
TUPLE1 |
|
22q11.2 |
|
|
ARSA |
|
22q13.3 |
|
|
|
7cen |
7p11.1-q11.1 |
|
|
|
|
|
| GERM CELL TUMORS |
|
|
|
|
|
i(12)(p10) |
D12Z3 |
|
12p11.1-q11.1 |
| |
|
ETV6 |
|
12p13 |
|
 Send Feedback to: Webmaster at cytogenetics@partners.org
This page was last modified on 2/10/2008
|
