Endocrinology, Diabetes and Hypertension

Caroline Fox, M.D.

Dr. Fox is a Medical Officer at the Framingham Heart Study, and is employed by the National Heart, Lung, and Blood Institute of the National Institutes of Health. 

Dr. Fox has three major focuses of research:  obesity, diabetes, and chronic kidney disease.  She conducts both population-based epidemiologic research, as well as genetic epidemiology research at the Framingham Heart Study, including linkage analysis and candidate gene association studies.  Dr. Fox is the Director of the Computed Tomography Abdominal Adiposity Study, a study measuring subcutaneous and visceral adipose tissue volumes in several thousand participants of the Framingham Heart Study.  This study is investigating the relations between metabolic risk factors and adipose tissue compartments, and genes that underlie differential adipose tissue deposition.  Dr. Fox also performs research in diabetes and metabolic syndrome, focusing on relations with cardiovascular disease, as well as in trends over time.  She is interested in the relation between cardiovascular disease risk factors and chronic kidney disease, as well as genes that underlie chronic kidney disease.

Selected References:

1. Fox CS, Larson MG, Leip EP, Culleton B, Wilson PW, Levy D. Predictors of new-onset kidney disease in a community-based population. JAMA 2004; 291(7):844-850.
2. Fox CS, Heard-Costa NL, Wilson PW, Levy D, D'Agostino RB Sr, Atwood LD.  Genome-wide linkage to chromosome 6 for waist circumference in the Framingham Heart Study.Diabetes 2004 May;53(5):1399-402
3. Fox CS, Coady S, Sorlie PD, Levy D, Meigs JB, Wilson PW, D’Agostino RB Sr, Savage P.  Trends in Cardiovascular Disease Complications of Diabetes JAMA 2004 Nov 24;292(20):2495-9
4. Fox CS, Larson MG, Leip EP, Meigs JB, Wilson PW, Levy D. Glycemic status and development of kidney disease: the framingham heart study. Diabetes Care 2005; 28(10):2436-2440.
5. Fox CS, Yang Q, Cupples LA, Guo CY, Atwood LD, Murabito JM, Levy D, Mendelsohn ME, Housman DE, Shearman AM. Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study. J Clin Endocrinol Metab 2005; 90(11):6257-6262.
6. Fox CS, Heard-Costa NL, Vasan RS, Murabito JM, D'Agostino RB, Sr., Atwood LD. Genomewide linkage analysis of weight change in the Framingham Heart Study. J Clin Endocrinol Metab 2005; 90(6):3197-3201.

 Contact Information:
csfox@bics.bwh.harvard.edu