Endocrinology, Diabetes and Hypertension

Rajesh Garg, M.D.

Dr. Garg’s research focuses on the effects of obesity and macronutrients on inflammation and atherosclerosis.  He has projects investigating 1) the effect of insulin infusion therapy on cerebral infarct size in acute ischemic stroke and 2) racial differences in oxidative and inflammatory stress and their effect on complications of type 2 diabetes mellitus.

Selected References:

1. Garg R, Kumbkarni Y, Aljada A, Mohanty P, Ghanim H, Hamouda W, Dandona P.  Troglitazone reduces reactive oxygen species generation by leukocytes and lipid peroxidation and improves flow-mediated vasodilatation in obese subjects.  Hypertension 2000;36(3):430-5.
2. Ghanim H, Garg R, Aljada A, Mohanty P, Kumbkarni Y, Assian E, Hamouda W, Dandona P.  Suppression of Nuclear Factor-kappa B and Stimulation of Inhibitor kappa B by Troglitazone: Evidence for an Anti-inflammatory Effect and a Potential Antiatherosclerotic Effect in the Obese.  J Clin Endocrinol Metab 2001; 86(3):1306-1312.
3. Chaudhuri A, Janicke D, Wilson MF, Tripathy D, Garg R, Bandyopadhyay A, Calieri J, Hoffmeyer D, Syed T, Ghanim H, Aljada A, Dandona P. Anti-Inflammatory and Profibrinolytic Effect of Insulin in Acute ST-Segment-Elevation Myocardial Infarction. Circulation. 2004;109:849-854.
4. Garg R, Chaudhuri A, Munschauer F, Dandona P.  Hyperglycemia, Insulin and Acute Ischemic Stroke: A Mechanistic Justification for a Trial of Insulin Infusion Therapy. Stroke 2005 Nov 23; (online ahead of publication).