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Principal Investigator(s): Cynthia C. Morton, PhD
Group Member(s): Barbara van Lingen
To identify genes essential for hearing, we constructed the first human fetal cochlear cDNA library. The cochlear cDNA library is a resource for researchers studying human deafness and facilitates identification of genes expressed in the human membranous labyrinths. Several genes which appear to be important for hearing have already been identified in this cDNA library including COCH (Coch5B2) and antiquitin. Mutations in the COCH gene have been found in patients with the autosomal dominant nonsyndromic deafness disorder, DFNA9. It is anticipated that more genes important for hearing will continue to be identified following the characterizing of additional clones from the cochlear cDNA library.
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