Principal Investigator: JoAnn E. Manson, MD, DrPH
Group Members: Julie E. Buring, ScD; Christine M. Albert, MD, MPH; Nancy R. Cook, ScD
The Women's Antioxidant and Folic Acid Cardiovascular Study (also known as the Women's Antioxidant Cardiovascular Study [WACS]) is a randomized, double-blind, placebo-controlled trial evaluating several micronutrients -- vitamin E, vitamin C, beta-carotene, and a combined supplement of folic acid, vitamin B6 and vitamin B12 -- in the prevention of cardiovascular disease events among 8,171 women at high risk of such events, either because they have a prior history of cardiovascular disease or because they have three or more major risk factors for cardiovascular disease. The trial will also examine whether these micronutrients are useful in preventing vision problems and cognitive decline.
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