Physiology
Principal Investigator:
Norman K Hollenberg, MD, PhD
Renal and VascularPharmacology
Our first major line of investigation involves the role of the renin angiotensin system in hypertension and diabetes mellitis. Specific foci include:
- Pharmacological interruption of the renin angiotensin system
- Pathogenesis of sodium-sensitive hypertension
- Search for a digitalis-like factor that influences renal sodium handling
- Intrarenal angiotensin II generation in control of the renal circulation
- Genetic mechanisms in diabetic nephropathy
- Genetic factors in the pathogenesis of essential hypertension in a subgroup called "non-modulators"
Our second line of investigation involves growth and reactivity of collateral arterial blood vessels after occlusion of a major artery. The primary tools employed in these studies are angiography, blood flow measurement, and pharmacological interruption of pathways that affect growth and reactivity. Recent emphasis has been placed on serotonin and thromboxane and on the contribution of endothelium-dependent vasodilator release to acute dilation and early growth.
Norman K Hollenberg, MD, PhD
Director, Physiologic Research
Department of Radiology
Brigham and Women's Hospital
Professor of Medicine
Harvard Medical School
Boston, MA 02115
Telephone: 617-732-6682
Send Feedback to: 
