Paul J. Anderson Laboratory
Paul J. Anderson, MD, PhD
Principal Investigator
K. Frank Austen Professor of Medicine, Harvard Medical School
Senior Physician, Brigham and Women's Hospital
Messenger RNA is in constant flux between different locations and states -- the nucleus
and cytoplasm, activation silencing, transition and decay. Classical nuclear bodies such
as nucleoli and nuclear specklies are self-generated RNA structures whose morphology
and function are inextricably linked: altered morphology reflects altered function.
Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs)
have been revealed as functional byproducts of mRNA metabolism. SGs and PBs share
substrate mRNA, dynamic properties and many proteins, but also house separate
components and independent functions. Each can exist without the other, but when
coodinately induced they are often tethered together in a cystolic dance. Work in the
laboratory is focused on understanding the role of subcellular localization in the control
of mRNA translation/decay.
The Anderson Lab is in the Division of Rheumatology, Immunology, and Allergy at
Brigham and Women’s Hospital, and is affiliated with Harvard Medical School.
We are located on the sixth floor of the Smith Building, One Jimmy Fund Way, Boston, MA.
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