Medicine: Division of Rheumatology, Immunology and Allergy

Plenge Lab: Publications

Plenge RM. Shared Genetic Risk Factors for Type 1 Diabetes and Celiac Disease [editorial]. New Eng J Med 2008; 359(26):2837-8.

Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FAS, Chang M, Catanese JJ, Ding B, Wong SL, van der Helm-van Mil AHM, Neale BM, Coblyn J, Cui J, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TWJ, Shadick NA, Weinblatt ME, Worthington J, Seielstad M, Toes REM, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM. Common variants at CD40 and other loci confer risk of rheumatoid arthritis.  Nat Genet 2008; 40(10):1216-23.

Plenge RM, Criswell LA. Genetic variants that predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis: current challenges and future directions. Curr Opin Rheumatol 2008; 20(2):145-52.

Plenge RM*, Seielstad M*, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies LRL, Li W, Tan AKS, Bonnard C, Ong RTH, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli J, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, W, Kastner DA, Klareskog L*, Gregersen PK*. Genome-wide search identifies TRAF1-C5 as Rheumatoid Arthritis Risk Locus.  New Eng J Med 2007; 357(12):1199-209. *contributed equally

Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PIW, Maller J, Pe’er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Izmailova E, Roubenoff R, Parker AN, Coblyn J, Weinblatt ME, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Brenner MB, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ, Altshuler D. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007; 39(12):1477-82.

Remmers EF*, Plenge RM*, Lee AT, Graham RR, Hom G, Behrens TW, de Bakker PIW, Le JM, Lee H, Batliwalla F, Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos CI, Criswell LA, Seldin MF, Kastner DL, Gregersen PK. A variant form of STAT4 increases genetic susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus. New Eng J Med 2007; 357(10):977-86.  (*contributed equally)

Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D.  Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38:904-9.

Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD. Replication of putative candidate gene associations with rheumatoid arthritis in over 4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4 and PADI4. Am J Hum Genet 2005; 77:1044-60.

Percec I, Plenge RM, Nadeau JH, Bartolomei MS, Willard HF. Autosomal dominant mutations affecting X inactivation choice in the mouse.  Science 2002; 296:1136-9.

Plenge RM, Hendrich BD, Schwartz C, Arena JF, Naumova A, Sapienza C, Winter RM, Willard HF. A promoter mutation in the XIST gene in two unrelated families with skewed X chromosome inactivation. Nat Genet 1997; 17:353-6.