|  Research Summary  |  Equipment & Techniques  |  Funding  |  Publications  |

Research Summary

Current research in our lab is focused on crosstalk between two fundamental second messenger systems: Ca2+ and cyclic AMP (cAMP). We have been using a panel of molecular, biochemical, biophysical and fluorescence imaging tools to study how these signaling cascades intersect with one another in colonic epithelial cells. Our studies will help us to understand the normal functions of colonic epithelia, and potentially to understand whether aberrations in signaling precede or accompany neoplastic transformation. Our work is supported principally through a Merit Review Award from the Medical Research Service of the Veteran’s Administration, awarded to A.M. Hofer (Principal Investigator)

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Equipment & Techniques

Novascan ESPM 3D AFM (Atomic Force Microscope), BioRad Multiphoton Microscope, Nikon C1si spectral confocal system

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Funding

1. Merit Review Award - Medical Research Service of the Veteran's Administration (PI: A.M. Hofer, 2007 - 2011) -- "Imaging cAMP in colon: inflammatory mediators and CA2+ - sensing receptors"

2. Harvard Digestive Diseases Center Pilot/Feasibility Award (PI: A.M. Hofer, 2007 - 2008) -- "cAMP microdomains in G.I. epithelia"

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Publications

To access Dr. Aldebaran Hofer's publications, please click here.

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Aldebaran Hofer
PhD

VA Boston Healthcare System

Research Interests

Ca2+ and Cyclic AMP (cAMP)