Major Research Interests
1. The role of heat therapy in the management of symptomatic Benign Prostatic Hyperplasia (BPH)
2. The role of urodynamic evaluation in symptomatic BPH
3. Ileal neobladder following cystoprostatectomy in bilharzial bladder cancer
4. Urinary incontinence following radical prostatectomy
5. The epidemiology of testis cancer
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Projects
1. Dr. Steele investigated the role of radiofrequency wave energy in the treatment of Benign Prostatic Hyperplasia (BPH) using Transurethral Needle Ablation of the Prostate. This technique was shown in a long term urodynamics based study to produce durable objective improvements in voiding pressures and flow rates. Research was subsequently expanded to define the role of radiofrequency technology in urinary retention due to BPH..
2. Dr. Steele conducted a prospective urodynamics based study on the mechanism of urinary continence and the pathogenesis of urinary incontinence via an analysis of urodynamic changes following radical prostatectomy. This research showed the importance of the intrinsic sphincter zone length in urinary continence following radical prostatectomy and the need for urethral length preservation during radical prostatectomy.
3. The diagnosis of detrusor instability (DI) is often inferred from clinical history despite lack of urodynamic evidence of the presence of DI. Dr. Steele found isometric detrusor pressure (Piso) in the absence of obstruction to be a reliable predictor of DI even in patients who did not demonstrate DI during the cystometry phase of the urodynamic study.
4. Dr. Steele researched the role of urodynamic studies in male patients with Benign Prostatic Hyperplasia (BPH) and lower urinary tract symptoms (LUTS). He prospectively performed comprehensive urodynamic studies on a large group of patients who were divided into obstructed and non-obstructed groups based on voiding pressure at maximum flow rate (PdetQmax). Other parameters measured were prostate volume and urinary flow rates, and used in combination with the AUA symptom index (AUASI)to determine accuracy of predicting outlet obstruction. A combination of AUASI > 20, prostate volume > 40 grams and maximum urinary flow rate of < 10 predicted bladder outlet obstruction in 100% of patients with these parameters.
5. The role of detrusor pressure at maximum urinary flow rate (PdetQmax) is the gold standard for defining bladder obstruction in male patients with Benign Prostatic Hyperplasia (BPH). Recent reports of Detrusor contraction duration as a more reliable parameter seemed counterintuitive. Dr. Steele subsequently measured Detrusor contraction duration in a large cohort of men with lower urinary tract symptoms (LUTS) and enlarged prostates and found little correlation between Detrusor contraction duration and presence or absence of bladder outlet obstruction.
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Publications
For the latest articles by Dr. Graeme Steele, please visit 
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Steele GS, Richie JP. The management of nonseminomatous testicular cancer. Scientific World Journal. 2004 Jun 7;4 Suppl 1:316-29.
Steele GS, Richie JP. Management of low-stage nonseminomatous germ cell tumors of the testis. Compr Ther. 2000 Fall;26(3):210-9. Review.
Steele GS, Clancy TE, Datta MW, Weinstein M, Richie JP. Angiosarcoma arising in a testicular teratoma. J Urol. 2000 Jun;163(6):1872-3.
Steele GS, Sullivan MP, Sleep DJ, Yalla SV. Combination of symptom score, flow rate and prostate volume to predict bladder outflow obstruction adult men with lower urinary tract symptoms. J Urol 2000 Aug;164(2):344-8
Steele GS, Richie JR: The role of RPLND in Testis Tumors. Contemporary Urology 2000 Aug; 12;8: 12-26
Steele GS, Richie JR: Therapy for low stage Testis Tumors. Comprehensive Therapy Vol 26:3 Fall 2000 210-219
Steele GS, Richie JP, Stewart AK, Menck HR. The National Cancer Data Base report on patterns of care for testicular carcinoma, 1985-1996. Cancer 1999 Nov 15; 86(10):2171-83
Hoffman M, Steele G, Yalla SV: Acute bacterial endocarditis secondary to prostatic abscess. J Urol 2000 Jan;163(1):245
Kerfoot BP, Steele GS, Datta M, Richie JR: Carcinoid tumor in an ileal loop urinary diversion. J Urol 1999 Nov;162(5):1685-6
Steele GS, Sullivan MP, Yalla SV: Changes in detrusor contractility, detrusor compliance and outlet properties after radical prostatectomy. J Endourol 1998 12(1):1 29.
Steele GS: Transurethral needle ablation of the prostate a prospective urodynamic study with 2 year follow-up. J Endourol 1998 12(1): 107
Steele GS, Richie JP: Management of Nonseminomatous Germ Cell Tumors of the Testis. Digital Journal of Urology. May 1998
Ameda K, Steele GS, Sullivan MP, Stember D, Yalla SV. Detrusor contraction duration as a urodynamic parameter of bladder outlet obstruction for evaluating men with lower urinary tract symptoms. J Urol. 1998 Aug;160(2):482-6.
Steele GS, Richie JP: Positive margins in prostate cancer surgery. Contemporary Urology. 1998 10, (8), 74
Kibel A, Steele GS, Santis W, Yalla SV. Penile necrosis after coronary artery bypass grafting. Brit J Urol.1998, 81:508-509
Steele GS, Renshaw A, Fielding J, Loughlin KR. Transitional cell carcinoma of the fossa navicularis. Urology 1997 Nov;50(5):792-5
Steele GS, Sleep DJ. Transurethral Needle Ablation of the Prostate: A Urodynamic based study with 2 year follow up. J Urol 1997 Nov, 158(5):1834-8 Transurethral needle ablation of the prostate: a urodynamic based study with 2-year followup.
Steele GS, Richie JP. Surgery and Chemotherapy in the management of advanced nonseminomatous testicular cancer. Current Opinion in Urology 1997, 7:304-311
Fielding J, Steele GS, Fox LA, Seltzer SE, Heller H. Spiral CT in the evaluation of flank pain, accuracy and feature analysis. J Comp Ass Tomog.1997, 21(4):635-638
Steele GS, Richie JP. The current role of surgery in the management of testicular cancer.Oncology (Huntingt) 1997 May;11(5):717-29; Current role of retroperitoneal lymph node dissection in testicular cancer.
Fielding JR, Steele GS, Fox LA, Heller H, Loughlin KR. The role of the non contrast spiral CT scan in the management of ureteric stones. J Urol 1997 Jun;157(6):2071-3 Spiral computerized tomography in the evaluation of acute flank pain: a replacement for excretory urography.
Steele GS, Sleep DJ. Transurethral needle ablation of the prostate: a urodynamic based study with 2-year followup. J Urol 1997 Nov;158(5):1834-8
Cohen RJ, Haffejee Z,Nayler SJ, Steele GS: Advanced prostate cancer with normal serum PSA levels. Arch Path Lab Med 1994 118:1123-6
Steele, GS. Urinary Diversions: New Techniques. S.A. Journal of Continuing Medical Education, 1994, October: 35 -41.
Steele, GS: The management of low stage testicular cancer. S.A. Journal of Urology, 1993, 3:18 - 22.
Sleep, DJ, Steele, GS: The medical management of BPH. S.A. Journal of Urology, 1993, 2:16-21.
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