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Research Summary

The focus of our lab is the response to shock and injury in animal and human models on the cellular level. The rat model of hemorrhagic shock has been the mainstay of my research and has led to the development of key insights in the role of HSP-70 in shock physiology.

In the past year, I have begun a close collaboration with Dr. David Soybel. We have used the rat model to investigate Zinc homeostasis in shock and resuscitation, and have developed new insights in Zinc metabolism in immune cells during resuscitation.

Other projects have included the role of HSP-70 in traumatic brain injury in the evolution of posttraumatic hydrocephalus, thermal homeostasis in hemorrhage and resuscitation using quantitative Far Infrared Imaging, and organ specific oxygen metabolism using Near Infrared Spectroscopy. Our recent interest in Infrared technology has led to collaboration with two medical technology companies for translational research into clinical applications for Infrared monitoring.

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Equipment & Techniques

Dissecting microscope, multichannel hemodynamic monitor, chemiluminescent molecular assays for mRNA and protein analysis, immunofluorescence, digital imaging

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Publications

To access Dr. Edward Kelly's publications, please click here.

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Edward Kelly
MD

Clinical Profile & Contact Information

Research Interests

Shock and Injury Response
HSP-70