Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder characterized by unexplained left ventricular hypertrophy (increased heart muscle thickness), myocyte disarray (disorganized cardiac cells) and fibrosis. It is the most common heritable cardiovascular disorder with an estimated prevalence of 1/1000 in the general population.
Genetic studies have defined HCM as a disease of the sarcomere, with more than 1,000 mutations identified in 11 different components of the contractile apparatus of the heart. Although most individuals with HCM do well with appropriate treatment, this condition can be associated with an increased risk for progressive heart failure and sudden death.
An integrative approach, with particular attention to unique features of this disorder, is essential for optimal management of patients and families with hypertrophic cardiomyopathy. Our multidisciplinary clinic provides:
Carolyn Ho, MD, Medical Director of the Cardiovascular Genetics Center at Brigham and Women’s Hospital (BWH), discusses the role of genetics in the development of heart diseases such as hypertrophic cardiomyopathy. Read the Advancing Care for Inherited Heart Disease video transcript.
To make an appointment in the HCM Clinic call: 857-307-4000
Click here to find clinical trials related to HCM.
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