Extensive research efforts at the Stroke and Cerebrovascular Center at Brigham and Women’s Hospital include many NIH-funded studies designed to lead to new therapies for stroke and cerebrovascular disease.
Researchers at the Center are examining:
Mechanisms of neuroapoptosis, or programmed cell death, in the evolution of stroke
Use of neuroprotective agents to minimize cell death in stroke, traumatic brain injury, and cerebrovascular disease
Markers and mechanisms of injury in stroke
Micro- and cerebrovascular pathophysiology, molecular pathology, and therapeutic ramification of stroke
Endovascular devices, such as the Concentric® MERCI Retrieval System
Transcranial Doppler ultrasound in the study of hemodynamic pathophysiology
Genetic basis for cerebrovascular disorders, including aneurysms
Ongoing clinical trials include the development of new methods to lyse intracranial clots to reestablish blood flow faster and more extensively than can be achieved with medications alone. The Division of Vascular Surgery at Brigham and Women’s Hospital is also participating in the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) to compare carotid endarterectomy to angioplasty and carotid stenting in patients with carotid artery stenosis.