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Boyce Lab Publications

Original Publications

Nagai J, Balestrieri B, Fanning LB, Kyin T, Cirka H, Lin J, Idzko M, Zech A, Kim EY, Brennan PJ, Boyce JA. P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation. J Clin Invest. 2019 Dec 02; 129(12):5169-5186. PMID: 31638598.

Boyce JA. Legends of allergy and immunology: K. Frank Austen. Allergy. 2019 Sep 27. PMID: 31560800.

Cahill KN, Cui J, Kothari P, Murphy K, Raby BA, Singer J, Israel E, Boyce JA, Laidlaw TM. Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-exacerbated Respiratory Disease. A Prospective Trial. Am J Respir Crit Care Med. 2019 Sep 15; 200(6):704-711. PMID: 30978291.

Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 05; 12(3):679-690. PMID: 30664709.)

Cahill KN, Murphy K, Singer J, Israel E, Boyce JA, Laidlaw TM. Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 Feb; 143(2):799-803.e2. PMID: 30339852.

Ordovas-Montanez J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory progenitor cells. Nature. 2018 Aug;560(7720):649-654.

Laidlaw TM, Cahill KN, Cardet JC, Murphy K, Cui J, Dioneda B, Kothari P, Raby BA, Israel E, Boyce JA. A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol. 2019 Jan;143(1):316-324.

Pan D, Buchheit K, Samuchiwal S, Liu T, Cirka H, Raff H, Boyce JA. Cyclooxygenase 1 mediates IL-33-induced extracellular signal regulated kinase activation in mast cells; Implications for aspirin sensitivity. J. Allergy Clin. Immunol. 2018 Jul 12. pii: S0091-6749(18)30996-5.

Liu T, Barrett NA, Kanaoka Y, Yoshimoto E, Garofalo D, Feng C, Boyce JA. Type 2 cysteinyl leukotriene receptors drive IL-33-dependent type 2 immunopathology and aspirin sensitivity. J. Immunol. 2018 200:915-927.

Samichuwal S, Balestrieri B, Raff H, Boyce JA. Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cyclic cAMP-EPAC-dependent pathway. J. Biol. Chem. 2017 292(20):8195-8206.

Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Weschler ME, Laidlaw TM, Boyce JA, Israel E. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N. Engl. J. Med. 2017 76(20):1911-1920.

Bankova LG, Lai J, Yoshimoto E, Boyce JA, Austen KF, Kanaoka Y, Barrett NA. Proc. Natl. Acad. Sci. USA 2016;113:6242-7.

Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D generation in patients with aspirin-exacerbated respiratory disease. J. Allergy Clin. Immunol. 2016; 137:1566-71.

Kondeti V, Al-Azzam N, Duah E, Thodeti CK, Boyce JA, Paruchuri S..Leukotriene D and prostaglandin E signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. J. Allergy Clin. Immunol. 2016;137:289-298.

Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM. 2015. Impaired EP Expression Causes Resistance to Prostaglandin E in Nasal Polyp Fibroblasts from Subjects with AERD. Am. J. Respir. Cell Mol. Biol. 2016;54:34-40.

Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw T M, Katz HR, Boyce JA. 2015. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J. Immunol. 195: 3537-3545.

Liu T., Garofalo D, Feng C, Lai J, Katz H, Laidlaw TM, and Boyce JA. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. J. Immunol. 2015;194: 5061-5068.

Liu T, Garofalo D, Feng C, Lai J, Katz H, Laidlaw TM, Boyce JA. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. J.Immunol. 2015 Jun 1;194(11):5061-8. PMCID: PMC4433852

Cahill KN, Bensko JC, Boyce JA, Laidlaw TM. Prostaglandin D2: a Dominant Mediator of Aspirin Exacerbated Respiratory Disease. J Allergy Clinical Immunology 2015; 135:235-242

Laidlaw TM, Cutler A, Kidder M, Chhay H, Cardet JC, Feng C, Liu T, Boyce JA. Prostaglandin E2 Resistance in Granulocytes from Patients with Aspirin Exacerbated Respiratory Disease. J. Allergy Clinical Immunology. 2014.

Cummings HE, Liu T, Feng C, Laidlaw TM, Conley PB, Kanaoka Y, Boyce JA. Cutting Edge: Leukotriene C4 Activates Mouse Platelets in Plasma Exclusively through the Type 2 Cysteinyl Leukotriene Receptor. J Immunol. 2013 Dec 15; 191:5807-5810.

Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids Health Dis. 2013; 12:141.

Liu T, Laidlaw TM, Katz HR, Boyce JA. Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A. 2013 Oct 15; 110:16987-16992.

Kondeti V, Duah E, Al-Azzam N, Thodeti CK, Boyce JA, Paruchuri S. Differential regulation of cysteinyl leukotriene receptor signaling by protein kinase C in human mast cells. PLoS One. 2013 Aug 15;8(8):e71536. PMCID: PMC3744564

Barrett NA, Boyce JA. Activation of group 2 innate lymphoid cells: a new role for cysteinyl leukotrienes [comment]. J Allergy Clin Immunol. 2013 Jul;132(1):214-6. PMID: 23810099 [PubMed - in process]

Ohta S, Imamura M, Xing W, Boyce JA, Balestrieri B. Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J Immunol. 2013 Jun 15;190(12):5927-38. PMID: 23650617 [PubMed - indexed for MEDLINE].

Laidlaw TM, Boyce JA. Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunol Allergy Clin North Am. 2013 May;33(2):195-210. PMID: 23639708 [PubMed - in process]

Boyce JA, Peebles RS. Regulation of Th9-type pulmonary immune responses: a new role for COX-2 [comment]. Am J Respir Crit Care Med. 2013 Apr 15;187(8):785-6. PMID: 23586375 [PubMed - indexed for MEDLINE]

Bochner BS, Rothenberg ME, Boyce JA, Finkelman F. Advances in mechanisms of allergy and clinical immunology in 2012. J Allergy Clin Immunol. 2013 Mar;131(3):661-7. PMID: 23352632 [PubMed - indexed for MEDLINE]

Laidlaw TM, Boyce JA. Cysteinyl leukotriene receptors, old and new; implications for asthma. Clin Exp Allergy 2012: 2012 Sep;42(9):1313-20. PMID: 22925317 [PubMed - indexed for MEDLINE]

Liu T, Laidlaw TM, Feng C, Xing W, Shen S, Milne G, Boyce JA. Prostaglandin E2 deficiency uncovers a dominant effector role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation and vascular remodeling. Proc Natl Acad Sci U S A 2012;109:12692-97. PMCID: PMC3411985

Laidlaw TM, Kidder MS, Bhattacharyya N, Xing W, Shen S, Milne GL, Castells MC, Chhay H, Boyce JA. Cysteinyl leukotriene overproduction in aspirin exacerbated respiratory disease is driven by platelet-adherent leukocytes. Blood 2012;119:3790-8. PMCID: PMC3335383

Bunyavanich S, Boyce JA, Raby BA, Weiss ST. Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma. Clin Exp Allergy 2012;42:229-37. PMCID: PMC3353543

Laidlaw TM, Steinke JW, Tiñana AM, Feng C, Xing W, Lam BK, Paruchuri S, Boyce JA, Borish LC. Characterization of a novel human mast cell line that responds to stem cell factor and expresses high levels of functional Fc-epsilon-RI. J Allergy Clin Immunol. 2011;127:815-22. PMCID: PMC3052637

Giannatassio G, Fujioka D, Xing W, Katz HR, Boyce JA, Balestrieri B. Group V secretory phospholipase A2reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function. J Immunol. 2010;185:4430-8. PMCID: PMC3003260

Simarro M, Giannattasio G, De la Fuente MA, Benarafa C, Subramanian KK, Ishizawar R Balestrieri B, Andersson EM, Luo HR, Orduña A, Boyce J, Anderson P. Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol. 2010;184:5325-32. PMCID: PMC2858774

Lundequist A, Nallamshetty SN, Xing W, Feng C, Laidlaw TM, Uematsu S, Akira S, Boyce JA. Prostaglandin E2exerts homeostatic control over pulmonary vascular remodeling in allergic airway inflammation. J Immunol. 2010;184:433-41. PMCID: PMC3721536

Paruchuri S, Tashimo H, Feng C, Maekawa A, Xing W, Jiang Y, Kanaoka Y, Conley P, Boyce JA. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med 2009;206:2543-55. PMCID: PMC2768854

Moore ML, Parekh VV, Van Kaer L, Collins RD, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin J, Peebles RS Jr. STAT1 negatively regulates lung basophilia induced by respiratory syncytial virus infection. J Immunol 2009;183:2016-26. PMCID: PMC3755459

Jiang Y, Borrelli L, Bacskai BJ, Kanaoka Y, Boyce JA. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol 2009;182:1129-37. PMCID: PMC2615395

Paruchuri S, Jiang Y, Feng C, Francis SA, Plutzky J, Boyce JA. Leukotriene E4 activates peroxisome proliferator activated receptor gamma and induces prostaglandin D2 generation by human mast cells. J Biol Chem 2008;283:16477-87. PMCID: PMC2423236

Jiang Y, Feng C, Backskai B, Boyce JA. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene-dependent mitogenic responses of mast cells. Blood 2007;100:3263-70. PMCID: PMC2200919

Gonzalo JA, Qiu Y, Lora JM, Al-Garawi A, Villeval JL, Boyce JA, Martinez AC, 13 Marquez G, Goya I, Hamid Q, Fraser CC, Picarella D, Cote-Sierra J, Hodge MR, Gutierrez-Ramos JC, Kolbeck R, Coyle AJ. Coordinated involvement of mast cells and T-cells in allergic mucosal inflammation critical role of the CCL1 CCR8 axis. J Immunol. 2007;179:1740-50.

Jiang Y, Kanaoka Y, Feng CL, Nocka K, Rao S, Boyce JA. Cutting Edge Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-dependent signaling. J Immunol. 2006;177:2755-9.

Abonia JP, Hallgren J, Jones T, Shi T, Xu Y, Koni P, Flavell RA, Boyce JA, Austen KF, Gurish MF. Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood 2006;108:1588-94.

Tournilhac O, Santos DD, Xu L, Kutok J, Tai YT, Le Gouill S, Cantley L, Hunter Z, Branagan AR, Boyce JA,Munshi N, Anderson KC, Treon SP. Mast cells in Waldenstrom's microglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling. Ann Oncol. 2006;17:1275-8.

Feng CL, Beller EM, Bagga S, Boyce JA. Human mast cells express multiple EP receptors for prostaglandin E2that differentially modulate activation. Blood 2006;107:3243-50.

Lin DA, Boyce JA. IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells. J Immunol. 2005;175:5430-8.

Feng CL, Mery AG, Beller EM, Favot CL, Boyce JA. Adenine nucleotides inhibit cytokine generation by human mast cells through a Gs-coupled receptor. J Immunol. 2004;173:7539-47.

Bagga S, Price KS, Lin D, Friend DS, Austen KF, Boyce JA. Lysophosphatidic acid accelerates the development of human mast cells. Blood 2004;104:4080-7.

Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DK, Beck LA, Boyce JA, Filipovich AH, Villanueva JM, Sutton SA, Assa'ad AH, Rothenberg ME. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol. 2004;113:115-9.

Lora JM, Al-Garawi A, Pickard MD, Price KS, Bagga S, Sicoli J, Hodge MR, Gutiérrez-Ramos J-C, Briskin M, Boyce JA. Fc-episilon-RI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines. J Allergy Clin Immunol. 2003;112:1119-26.

Mellor EA, Frank N, Soler D, Lora JM, Hodge MR, Austen KF, Boyce JA. Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells; Functional distinction from CysLT1R.Proc Natl Acad Sci U S A 2003;100:11589-93.

Price KS, Friend DS, Mellor EA, De Jesus NJ, Watts GF, Boyce JA. CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13. Am J Resp Cell Mol Biol. 2003;28:420-7.

Wong GW, Foster PS, Yasuda S, Qi JC, Mahalingham S, Mellor EA, Katsoulotos G, Li L, Boyce JA, Krilis SA, Stevens RL. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an IL-13/IL-4Ra/STAT6-dependent pathway. J Biol Chem. 2002;277:41906-15.

Gurish MF, Humbles AH, Tao H, Finkelstein S, Boyce JA, Gerard C, Friend DS, Austen KF. CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis. J Immunol.2002;168:5730-6.

Boyce JA, Mellor EA, Perkins B, Lim YC, Luscinskas FW. Human mast cell progenitors use alpha-4 integrin-VCAM-1 and PSGL-1-E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood 2002;99:2890-96.

Mellor EA, Austen KF, Boyce JA. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. J Exp Med. 2002;195;583-92.

Banner N, Farman M, Friend DS, Ochi H, Price KS, Sorokin J, Boyce JA. Human Mast cell precursors can be infected by macrophage tropic human immunodeficiency virus type 1 and retain virus with maturation in vitro. J Virol. 2001;75:10808-14.

Mellor EA, Maekawa A, Austen KF, Boyce JA. Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc Natl Acad Sci U S A 2001;98:7964-9.

Hou FF, Miyata T, Boyce J, Yuan Q, Chertow GM, Kay J, Schmidt AM, Owen WF. beta(2)-Microglobulin modified with advanced glycation end products delays monocyte apoptosis. Kidney Int. 2001;59:990-1002.

Silverman ES, De Sanctis GT, Boyce J, Maclean JA, Jiao A, Green FH, Grasemann H, Faunce D, Fitzmaurice G, Shi G, Stein-Streilein J, Milbrandt J, Collins T, Drazen JM. The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice. Am J Respir Crit Care Med. 2001;163:778-85.

Hsieh FH, Lam BK, Penrose JF, Austen KF, Boyce JA. T helper cell type 2 cytokines coordinately regulate IgE-dependent cysteinyl leukotriene production by human cord blood-derived mast cells profound induction of leukotriene C4 synthase expression by interleukin 4. J Exp Med. 2001;193;123-33.

Ochi H, De Jesus NH, Hsieh F, Austen KF, Boyce JA. IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production. Proc Natl Acad Sci U S A 2000;97:10509-13.

Hou FF, Boyce J, Zhang Y, Owen WF Jr. Phenotypic and functional characteristics of macrophage-like cells differentiated in pro-inflammatory cytokine-containing cultures. Immunol Cell Biol. 2000;78:205-13.

Ochi H, Hirani WM, Yuan Q, Friend D, Austen KF, Boyce JA. T helper type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med. 1999;190:267-80.

Owen WF Jr, Hou FF, Stuart RO, Kay J, Boyce J, Chertow GM, Schmidt AM. Beta-2 microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblasts. Kidney Int. 1998;53:1365-73.

Yuan Q, Gurish MF, Friend DS, Austen KF, Boyce JA. Generation of a novel stem cell factor-dependent mast cell progenitor. J Immunol. 1998;161:5143-6.

Hou FF, Boyce JA, Chertow GM, Kay J, Owen WF Jr. Aminoguanidine inhibits advanced glycation end products formation on beta-2 microglobulin. J Am Soc Nephrol. 1998;9:277-83.

Hou FF, Chertow GM, Kay J, Boyce J, Lazarus JM, Braatz JA, Owen WF, Jr. Interaction between beta 2-microglobulin and advanced glycation end products in the development of dialysis-related amyloidosis. Kidney Int. 1997;51:1514-9.

Yuan Q, Austen KF, Friend D, Heidtman M, Boyce JA. Human peripheral blood eosinophils express a c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1). J Exp Med. 1997;186:313-23.

Penrose JF, Spector J, Baldasaro M, Xu K, Boyce J, Arm JP, Austen KF, Lam BK. Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. J Biol Chem. 1996; 271:11356-61.

Boyce JA, Lam BK, Penrose JF, Friend DS, Parsons S, Owen WF, Austen KF. Expression of LTC4 synthase during the development of eosinophils from cord blood progenitors. Blood 1996;88:4338-46.

Boyce JA, Friend D, Gurish MF, Austen KF, Owen WF. Constitutive production of GM-CSF by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes. Proc Natl Acad Sci U S A 1996;2436-41.

Boyce JA, Friend D, Matsumoto R, Austen KF, Owen WF. Differentiation in vitro of hybrid eosinophil/basophil granulocytes autocrine function of an eosinophil developmental intermediate. J Exp Med. 1995;182:49-57.

Boyce JA, Bernhard JD. Routine total skin examination to detect malignant melanoma. J Gen Intern Med. 1987;2:59-61.

Boyce JA, Bernhard JD. Total skin examination Patient reactions. J Am Acad Dermatol. 1986;14:280.