Brenner Lab Publications

Original Articles

Veerapen N, Leadbetter EA, Brenner MB, Cox LR, Besra GS.  Synthesis of a novel alpha-galactosysl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies.  Bioconjug Chem 2010; 21:741-7.

Odyniec AN, Barral DC, Garg S, Tatituri RV, Besra GS, Brenner MB.  Regulation of CD1 antigen-presenting complex stability.  J Biol Chem 2010; 285:11937-47.

Muindi K, Cernadas M, Watts GFM, Royle L, Neville DCA, Dwek RA, Besra GS, Rudd PM, Butters TD, Brenner MB.  Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphinogolipids presented by CD1d.  Proc Natl Acad Sci U S A 2010; 107:3052-7.

Cernadas M, Cavallari M, Watts G, Mori L, De Libero G, Brenner MB.  Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens.  J Immunol 2010; 184:1235-41.

Kiener HP, Watts GFM, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM.  Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.  Arthritis Rheum 2010; 62:742-52.

Felio K, Nguyen H, Dascher CC, Choi H-J, Li S, Zimmer MI, Colmone A, Moody DB, Brenner MB, Wang C-R.  CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.  J Exp Med 2009; 206:2497-509.

Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB.  Rapid and reliable generation of invariant natural killer T-cell lines in vitro.  Immunology 2009; 128:324-33.

van Rhijn I, Young DC, de Jong A, Vazquez J, Cheng TY, Talekar R, Barral D, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB.  CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.  J Exp Med 2009; 206:1409-22.

Kiener HP, Niederreiter B, Lee DM, Jimenez-Boj E, Smolen JS, Brenner MB.  Cadherin-11 promotes invasive behavior of fibroblast-like synoviocytes.  Arthritis Rheum 2009; 60:1305-10.

Cernadas M, Lu J, Watts G, Brenner MB.  CD1a expression defines an interleukin-12 producing population of human dentritic cells.  Clin Exp Immunol 2009; 155:523-33.

Sada-Ovalle I, Chiba A, Gonzales A, Brenner MB, Behar SM.  Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.  PLoS Pathol 2008; 4:1-9.

Leslie DS, Dascher CC, Cembrola K, Townes MA, Hava DL, Hugendubler LC, Mueller E, Fox L, Roura-Mir C, Moody DB, Vincent MS, Gumperz JE, Illarinov PA, Gurdyal SB, Reynolds CG, Brenner MB.  Serum lipids regulate dendritic cell CD1 expression and function.  Immunology 2008; 125:289-301.

Chiba A, Dascher CC, Besra GS, Brenner MB.  Rapid NKT cell responses are self-terminating during the course of microbial infection.  J Immunol 2008; 181:2292-302.

Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB.  Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation.  Proc Natl Acad Sci U S A 2008; 105:11281-6.

Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB.  CD1a and MHC class I follow a similar endocytic recycling pathway.  Traffic 2008; 9:1446-57.

Kaser A, Hava DL, Dougan SK, Chen Z, Zeissig S, Brenner MB, Blumberg RS.  Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules.  Eur J Immunol 2008; 38:2351-9.

Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB.  NK T cells provide lipid antigen-specific cognate help for B cells.  Proc Natl Acad Sci U S A 2008; 105:8339-44.

Agarwal SK, Lee DM, Kiener HP, Brenner MB.  Coexpression of two mesenchymal cadherins, cadherin 11 and N-cadherin, on murine fibroblast-like synoviocytes.  Arthritis Rheum 2008; 58:1044-54.

Reviews, Chapters, Monographs and Editorials

Brigl M, Brenner MB.  How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens.  Sem Immunol 2010; 22:79-86.

Chang SK, Gu Z, Brenner MB.  Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11.  Immunol Rev 2010; 233:256-66.

Modlin RL, Brenner MB.  T cell responses in microbial infection.  Curr Opin Immunol 2009; 21:365-66.

Veerapen N, Illarionov P, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS.  Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.  Bioorg Med Chem Lett 2009; 19:4288-91.

Cohen NR, Garg S, Brenner MB.  Chapter 1 Antigen presentation by CD1: lipids, T cells and NKT cells in microbial immunity.  Adv Immunol 2009; 102:1-94.

Noss E, Brenner MB.  The role and the therapeutic implications of fibroblast-like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis.  Immunol Rev 2008; 223:252-70.