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Kanaoka/Barrett Lab Publications

go H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature 2007; 448:609-12.

Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho I-C, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. J Immunol2006; 176:4440-8.

Schmidt-Krey I, Kanaoka Y, Mills DJ, Irikura D, Haase W, Lam BK, Austen KF, Kühlbrandt W. Human leukotriene C4 synthase at 4.5 Å resolution in projection. Structure 2004; 12:2009-14.

Beller TC, Maekawa A, Friend DS, Austen KF, Kanaoka Y. Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem 2004; 279:46129-34.

Beller TC, Friend DS, Maekawa A, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Proc Natl Acad Sci USA 2004; 101:3047-52.

Fujitani Y, Kanaoka Y, Aritake K, Uodome N, Okazaki-Hatake K, Urade Y. Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. J Immunol 2002; 168:443-9.

Kanaoka Y, Maekawa A, Penrose JF, Austen KF, Lam BK. Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase. J Biol Chem 2001; 276:22608-13.

Maekawa A, Kanaoka Y, Lam BK, Austen KF. Identification in mice of two isoforms of the cysteinyl leukotriene 1 (CysLT1) receptor that result from alternative splicing. Proc Natl Acad Sci USA 2001; 98:2256-61.

Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell 1997; 90:1085-95.

Maekawa A, Austen KF, Kanaoka Y. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. J Biol Chem 2002; 277:20820-4.