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Loscalzo Laboratory

Research in the Loscalzo Cardiovascular Disease Lab uses an integrated approach from molecules to systems biology to define mechanisms underlying cardiovascular disease. Studies encompass: redox regulation of nitric oxide synthesis and bioavailability in thrombosis and pulmonary hypertension; the redox consequences of oxidative enzymopathies that contribute to common cardiovascular diseases such as atheroscleroris, thrombosis, hypertension and stroke; molecular responses to hypoxia, involving microRNA networks (hypoxamirs), that have consequences for pulmonary hypertension and other ischemic disorders; and regenerative biology, using targeting methods to improve stem cell delivery and repair in ischemia and other disorders of the vasculature and lung.  Discovery methods involving systems biology and network analysis, arrays and omics research are being used to develop new insights into molecular phenotypes that contribute to cardiovascular disease.