Cardiac Surgery Research

Research conducted by cardiac surgeons at the Brigham and Women’s Hospital (BWH) Heart & Vascular Center includes basic science and translational work that potentially brings discoveries from the laboratory to clinical research and patient application. Current clinical research includes new techniques to:

  • Repair heart valves
  • Improve cardiac revascularization and performance
  • Provide mechanical circulatory assistance and support to patients awaiting heart transplantation

In the research laboratory, we are studying:

  • Molecular genetics behind angiogenesis (the growth of new blood vessels that occurs with transmyocardial revascularization)
  • Biologic dynamics of cardiac infarction and congestive heart failure
  • Ischemic and reperfusion injury (the cellular damage that occurs when blood flows back into tissues that were temporarily deprived of circulation during surgery)
  • Molecular mechanisms involved in xenotransplantation (cross-species) of the heart using genetically-altered porcine hearts transplanted into primates
  • Heterograft valve replacement and the immunogenetics of valve transplant

Research Fellowship

Clinical research fellows are involved in the acquisition, analysis and publication of data of patients, who were operated on in the Division of Cardiac Surgery at Brigham and Women's Hospital. The aim of the clinical research is to demonstrate results and trends of new therapeutic procedures and compare interventions in cardiac surgery through retrospective and prospective studies that will help establish more effective treatments and therapeutic protocols. Work includes review of the literature, sampling and processing of patients data, and simple statistical (descriptive) analysis. Further, manuscripts are prepared for publication, depending on the importance of the results. Fellows also participate in the preparation of manuscripts for textbooks. For more information please contact:

Learn about Cardiac Surgery Research

Click on a surgeon’s name to learn more about cardiac surgery research projects.

We Need Your Help

Your contributions to our research will provide even better care for the next generation of patients. Donations can be directed toward:

  • Improving the role of surgery to improve patient outcomes
  • Improving surgical processes, techniques and protocols
  • Improving recovery after surgery
  • Understanding the needs of surgery patients

Support Our Work

Learn how you can support our cardiac surgery research projects.