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Before, During, and After a Leg Transplant

From the time we begin our search for a qualified leg transplant recipient to the continuing care we provide following surgery, a significant amount of time, expertise, and attentiveness is contributed toward making the procedure a progressive success. Below is an overview of what happens before, during, and after a leg transplant procedure. For a more thorough discussion of what a BWH leg transplant patient should expect, please review our Leg Transplant Patient Guide.

What happens before leg transplant surgery?

Leg transplant candidates go through an extensive screening process that is likely to last several months. This screening includes a psychiatric and social support evaluation and a series of imaging tests to help determine a patient’s physical and mental readiness for the procedure.

If, upon completion of the screening process, it is determined that a patient is a suitable candidate, we will place the patient on a transplant waiting list. We will then begin working with the New England Organ Bank (NEOB) team to find a donor who matches the recipient’s tissue requirements – e.g., similar age, correct blood type. This search could take many months, and, if a suitable donor is not found within one year, we will speak with the patient to determine whether they’re willing to continue waiting.

When a donor is found, we will immediately inform the patient about when to arrive at the hospital for the operation. As the timing for this type of procedure is extremely important, patients are expected to be readily available, i.e., reside within a 12-hour travel radius of BWH.

What happens during leg transplant surgery?

The parts most likely to be reconstructed during a leg transplant include the thigh, knee, lower leg, ankle, and foot. However, recipients with amputation levels above or below this level also will be considered for leg transplantation.

One surgical team will work on removing the leg from the donor as another team simultaneously prepares the leg on the recipient. Surgeons will then connect the donor leg’s blood vessels to the patient's blood vessels under a microscope to restore blood circulation before connecting nerves and other tissue, such as bone, cartilage, and muscles, as needed.

What happens after leg transplant surgery?

Immediately after surgery, the leg transplant recipient will be taken to the Intensive Care Unit (ICU) for observation. The patient will typically stay in the ICU for one or two days and then be moved to a private room. At this point, a physical therapist will start working with the patient to rehabilitate the transplanted leg, and a psychiatrist will discuss any psychological concerns.

The patient will stay in the hospital until both the plastic surgery and medical transplant teams agree that it is safe for the patient to return home. This post-operative stay is anticipated to be approximately 7-14 days, but can vary due to a number of factors. Rehabilitation with the physical therapist will take several hours a day while the leg transplant recipient is at the hospital.

Future visits

Following their discharge, leg transplant patients will need to return to BWH for routine visits. These visits will include monitoring transplant drug levels (immunosuppressants) through regular blood tests, rehabilitative therapy, imaging tests, assessing quality of life, and checking for the return of sensation and movement to the leg. Rehabilitation visits will take place daily for several months, whereas the other visits will typically take place on a weekly basis for the first three months and then at least once a month for the first year following surgery. In a case where the patient lives far away from BWH, we are anticipating that video conferences with collaborating medical centers will replace lengthy commutes.

After the first year, it is expected that leg transplant patients will need to visit the hospital less frequently. However, patients must be prepared to make a lifetime commitment to immunosuppressants to help prevent the rejection of the transplanted leg.


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