Cardiac amyloidosis is a group of diseases caused by deposits of abnormal proteins, or amyloid, in the heart. Cardiac amyloidosis causes the heart to become stiff and makes it difficult for the heart to work properly. This can cause fluid to build-up in the lungs, leading to breathlessness, and fluid build-up in soft tissues leading to the legs, causing abdominal swelling. Because cardiac amyloidosis can cause symptoms that are very similar to other heart diseases, it is often misdiagnosed.
The Cardiac Amyloidosis Program at Brigham and Women's Hospital (BWH) is the only clinical program of its kind in the U.S. focusing specifically on this disease. Led by Rodney H. Falk, MD, a renowned cardiac amyloidosis expert, this multidisciplinary program draws on the expertise of some of the country's leading cardiology specialists who collaborate on research and patient care at the state-of-the-art Heart & Vascular Center.
Because amyloidosis can affect other organs in addition to the heart, the spectrum of symptoms for cardiac amyloidosis can be quite broad, but may include:
Because the symptoms are common to other forms of heart disease like hypertrophic cardiomyopathy or heart failure, such as congestive heart failure, a careful physical examination and review of patient history play an important role in diagnosing cardiac amyloidosis.
Rodney H. Falk, MD, and the Brigham and Women’s Cardiac Amyloidosis Program are featured in this video. BWH's Cardiac Amyloidosis Program is the only clinical program in the U.S. focusing exclusively on cardiac amyloidosis. This unique program was established in order to help fill a significant void in the diagnosis and treatment of systemic amyloidosis, with a view to acquiring a better understanding of cardiac amyloidosis and improving care for patients who have the disease. Read the Advancing the Treatment of Cardiac Amyloidosis Video Transcript.
As patients with cardiac amyloidosis are very sensitive to sodium and retain fluid quickly, doctors will typically immediately limit salt intake. Diuretics may be prescribed to help the body remove excess fluid. Other treatments may include:
The Cardiac Amyloidosis Program at BWH provides comprehensive diagnostic and treatment services that include cardiac biopsy, genetic testing for patients with suspected familial amyloidosis, and precise assessment of cardiac function by state-of-the-art, noninvasive testing.
In addition to treatment for cardiac amyloidosis, patients at the Heart & Vascular Center may seek arrhythmia treatment, congestive heart failure treatment, and treatment for a broad range of other heart conditions.
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