Orthopaedic Research Laboratories

The Orthopaedic Research Laboratories bring together orthopedic surgeons and researchers to develop tomorrow's treatment options for patients with orthopedic problems. The approach is to translate new findings from basic and clinical investigations into a platform for skeletal health and orthopedic care. Emphasis is on chronic and acute orthopedic and joint diseases such as osteoarthritis, rheumatoid arthritis, problem fractures, sports injuries, bone cancers and metastases, spine diseases, osteoporosis, and skeletal aging.

Clinical investigations on disease risk factors and optimizing outcomes continue to provide evidence-based rationales for care improvement. New knowledge on mechanisms of disease translates into innovative approaches to prevention and treatment. Collaborations on cutting-edge diagnostic imaging techniques focus on early detection of musculoskeletal disease and monitoring of interventions.

Research on Tissue Engineering of cartilage, bone, intervertebral discs, knee menisci, and joints holds promise for innovative treatments for a variety of bone and joint problems. Advances are being made with cell-based, cell-free, and gene therapies.

Advanced polymer compositions provide scaffolds for implantation of genetically modified cells and tissue replacements, can release drugs targeted to specific sites, and can securely anchor orthopaedic implants. Research with innovative biomimetic materials is designed to tap into and augment the patient's regenerative potential.

Nanotechnology research highlights new bone cements that are stronger and more enduring for use to anchor orthopaedic implants, stabilize spinal fractures, and reconstruct skeletal defects left after trauma or tumor resections.