We are part of the Department of Medicine at the Harvard Medical School. Our laboratory is located on the 5th floor of the Smith Building at the Brigham and Women’s Hospital, which is located at One Jimmy Fund Way, Boston, MA 02115.
We have been focusing on understanding basic mechanisms of intracellular transport and their applications to understanding pathogenic basis of diseases. We have defined a novel function for GTPase-activating proteins (GAPs) that act on the ADP-Ribosylation Factor (ARF) small GTPases for intracellular transport. Besides their traditional role as key upstream regulators of ARFs, we have found that GAPs also act as novel downstream effectors, by being critical components of coat complexes. This insight has led us to identify additional factors critical for the formation of intracellular transport vesicles.
We are also applying these insights to elucidating cellular events in which transport mechanisms play critical roles, including cell migration that underlies tumor metastasis, glucose uptake for which defect leads to diabetes mellitus, and mechanisms of viral pathogenesis.