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Hsu Lab Publications

Selected work since 2018

Yang, J.S., Hsu, J.W., Park, S.Y., Li, J., Oldham, W.M., Beznoussenko, G.V., Mironov, A.A., Loscalzo, J., Hsu, V.W. GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis. Nature 2018 Sep;561(7722):263-267. doi: 10.1038/s41586-018-0475-6.

Park, S.Y., Yang, J.S., Li, Z., Deng, P., Zhu, X., Young, D., Ericsson, M., Andringa, R.L.H., Minnaard, A. J., Zhu, C., Sun, F., Moody, D.B., Morris, A.J., Fan, J., and Hsu, V.W. The late stage of COPI vesicle fission requires short forms of phosphatidic acid and diacylglycerol.  Nature Communications 2019 Jul 30;10(1):3409. doi: 10.1038/s41467-019-11324-4

Yang, J.S., Hsu, J.W., Park, S.Y., Lee, S.Y., Li, J., Bai, M., Alves, C., Tseng, W., Michelet, X., Ho, I.C., and Hsu, V.W. ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis. Nature Communications 2019 Sep 6;10(1):4068. doi: 10.1038/s41467-019-11932-0.

Hsu, J.W., Bai, B., Li, K., Yang, J.S., Chu, N., Cole, P.A., Eck, M.J., Li, J., and Hsu, V.W. The protein kinase Akt acts as a coat adaptor in endocytic recycling. Nature Cell Biology 2020 Aug;22(8):927-933. doi: 10.1038/s41556-020-0530-z.

Ghosh S, Dellibovi-Ragheb TA, Kerviel A, Pak E, Qiu Q, Fisher M, Takvorian PM, Bleck C, Hsu VW, Fehr AR, Perlman S, Achar SR, Straus MR, Whittaker GR, de Haan CAM, Kehrl J, Altan-Bonnet G, Altan-Bonnet N. ß-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway. Cell 2020 Dec 10; 183(6):1520-1535.e14. doi: 10.1016/j.cell.2020.10.039. 

Bainter W, Platt CD, Park SY, Stafstrom K, Wallace JG, Peters ZT, Massaad MJ, Becuwe M, Salinas SA, Jones J, Beaussant-Cohen S, Jaber F, Yang JS, Walther TC, Orange JS, Rao C, Rakoff-Nahoum S, Tsokos M, Naseem SUR, Al-Tamemi S, Chou J, Hsu VW, Geha RS. Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex. Journal of Clinical Investigation 2021 Feb 1;131(3):e140494. doi: 10.1172/JCI140494.

Zhang Y, Pang X, Li J, Xu J, Hsu VW, Sun F. Structural insights into membrane remodeling by SNX1. Proceedings of the National Academy of Sciences U S A. 2021 Mar 9;118(10):e2022614118. doi: 10.1073/pnas.2022614118.