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Current Research on Healthy Cognitive Aging

Successful Aging and Enrichment (SAGE) Study: Effects of environmental stimulation on cognitive health and neural plasticity

The goal of the SAGE study is to identify factors that promote cognitive and brain health in older adults. This will be accomplished through examining the impact of 4 different training programs. Two programs involve cognitive training, one involves training in mindfulness (awareness), and one involves physical training.

The investigation will compare the effects of different types of structured physical or mental stimulation over a 5 week training period on the following:

  1. Biological markers of brain plasticity (e.g., brain derived neurotrophic factor (BDNF))
  2. Electrophysiologic markers (event-related potentials) of neural efficiency and capacity
  3. Neuropsychological markers of cognitive performance
  4. Vascular markers of cerebral health (e.g., neurovascular coupling using Transcranial Doppler)

Currently Seeking Volunteers

  • 65 years of age or older
  • In good health

This study includes a baseline assessment at Brigham and Women’s Hospital (BWH), 5 weeks of training sessions in a participant’s home, and a post-intervention assessment at BWH.

Participants will be compensated for their time throughout the study. Individuals must meet study criteria to participate.

Anyone interested in learning more about the study should call the research team at (617) 732-8869 or email

More Clinical Trial Research Opportunities with Mass General Brigham


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