1. Loscalzo, J., Kallen, R. G., and Voet, D. (1973): The x ray structure of thiazolidine-4- carboxylic acid. Arch. Biochem. Biophys. 157:426-430.
2. Loscalzo, J., Reed, G. H., and Weber, A. (1975): Conformational change and cooperativity in actin filaments free of tropomyosin. Proc. Natl. Acad. Sci.USA 72:3412- 3415.
3. Loscalzo, J. and Reed, G. H. (1976): Spectroscopic studies of actin-metal-nucleotide complexes. Biochemistry 15:5407-5413.
4. Loscalzo, J., Reed, G. H., and Weber, A. How active is actin? Propagated conformational changes in the actin filament. In Search and Discovery. A Tribute to Albert Szent Gyorgyi. B. Kaminer, eds. New York: Academic Press, pp.99-106, 1977.
5. Lipton, S. A., Hickey, W. F., Morris, J. H., and Loscalzo, J. (1984): Candidal infection in the central nervous system. Am. J. Med. 76:101-108.
6. Loscalzo, J. and Handin, R. I. (1984): Conformational domains and structural transitions of human von Willebrand protein. Biochemistry 23:3880-3886.
7. Shorey, J., Bhardwaj, N., and Loscalzo, J. (1984): Acute Wernicke’s encephalopathy after intravenous infusion of high-dose nitroglycerin. Ann. Intern. Med. 101:500.
8. Adelman, B., Michelson, A. D., Loscalzo, J., Greenberg, J., and Handin, R. I. (1985): Plasmin effect on platelet glycoprotein Ib-von Willebrand factor interactions. Blood 65:32- 40.
9. Loscalzo, J., Fisch, M., and Handin, R. I. (1985): Solution studies of the quaternary structure and assembly of human von Willebrand factor. Biochemistry 24:4468-4475.
10. Loscalzo, J. (1985): N-acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. J. Clin. Invest. 76:703-708.
11. Loscalzo, J., Melnick, B., and Handin, R. I. (1985): The interaction of platelet factor four and glycosaminoglycans. Arch. Biochem. Biophys. 240:446-455.
12. Slayter, H., Loscalzo, J., Bockenstedt, P., and Handin, R. I. (1985): Native conformation of human von Willebrand protein. Analysis by electron microscopy and quasi-elastic light scattering. J. Biol. Chem. 260:8559-8563.
13. Bonthron, D. T., Handin, R. I., Kaufman, R. J., Wasley, L. C., Orr, E. C., Mitsock, L. M., Ewenstein, B., Loscalzo, J., and Orkin, S. H. (1986): Structure of pre-pro-von Willebrand factor and its expression in heterologous cells. Nature 324:270-273.
14. Goldhaber, S. Z., Markis, J. E., Meyerovitz, M. F., Kim, D. S., Dawley, D. L., Sasahara, A., Vaughan, D. E., Selwyn, A. P., Loscalzo, J., Kessler, C. M., Sharma, G. V. R. K., Grossbard, E. B., and Braunwald, E. (1986): Acute pulmonary embolism treated with tissue plasminogen activator. Lancet 2:886-889.
15. Loscalzo, J. and Antman, E. (1986): Artificial cardiac pacemakers: current concepts. J. Crit. Care 1:174-190.
16. Loscalzo, J., Inbal, A., and Handin, R. I. (1986): vonWillebrand protein facilitates platelet incorporation in polymerizing fibrin. J. Clin. Invest. 78:1112-1119.
17. Loscalzo, J., Slayter, H., Handin, R. I., and Farber, D. (1986): Subunit structure and assembly of von Willebrand factor polymer. Complementary analysis by electron microscopy and quasielastic light scattering. Biophys. J. 49:49-50.
18. Loscalzo, J. (1986): Paradoxical embolism: clinical presentation, diagnostic strategies, and therapeutic options. Am. Heart J. 112:141-145.
19. Loscalzo, J. and Freedman, J. (1986): Purification and characterization of human platelet glutathione-S-transferase. Blood 67:1595-1599.
20. Loscalzo, J. and Rabkin, D. (1986): The interaction of Tb3+ with human platelet surface. Arch. Biochem. Biophys. 249:237-242.
21. Michelson, A. D., Loscalzo, J., Melnick, B., Coller, B. S., and Handin, R. I. (1986): Partial characterization of a binding site for von Willebrand factor on glycocalicin. Blood 67:19-26.
22. Naftilan, A. J., Dzau, V. J., and Loscalzo, J. (1986): Preliminary observations on abnormalities of membrane structure and function in essential hypertension. Hypertension 8:II174-II179.
23. Goldhaber, S. Z., Meyerovitz, M. F., Markis, J. E., Kim, D., Kessler, C. M., Sharma, G. V. R. K., Vaughan, D. E., Selwyn, A. P., Dawley, D. L., Loscalzo, J., Sasahara, A. A., Grossbard, E. B., and Braunwald, E. (1987): Thrombolytic therapy of acute pulmonary embolism: current status and future potential. J. Am. Coll. Cardiol. 10:96B-104B.
24. Goldhaber, S. Z., Markis, J. E., Kessler, C. M., Meyerovitz, M. F., Kim, D., Vaughan, D. E., Selwyn, A. P., Loscalzo, J., Dawley, D. L., Sharma, G. V. R. K., Sasahara, A., Grossbard, E. B., and Braunwald, E. (1987): Perspectives on treatment of acute pulmonary embolism with tissue plasminogen activator. Semin. Thromb. Hemost. 13:171-177.
25. Graboys, T. B., Grossbard, C. L., and Loscalzo, J. (1987): Changes in cardiac rhythm among medical house officers undergoing ambulatory electrocardiographic monitoring. J. Cardiopul. Rehabil. 7:342-345.
26. Handin, R. I. and Loscalzo, J. Hemostasis, thrombosis, fibrinolysis, and cardiovascular disease. In Heart Disease. E. Braunwald, eds. Philadelphia: Saunders, pp.1758-1781, 1987.
27. Janicki, J. S., Weber, K. T., Loscalzo, J., and Shroff, S. (1987): Extracardiac pressure and ventricular haemodynamics. Cardiovasc. Res. 21:230-239.
28. Loscalzo, J. and Vaughan, D. E. (1987): Tissue plasminogen activator promotes platelet disaggregation in plasma. J. Clin. Invest. 79:1749-1755.
29. Loscalzo, J., Freedman, J., Rudd, M. A., Barsky-Vasserman, I., and Vaughan, D. E. (1987): Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. Arteriosclerosis 7:450-455.
30. Schafer, A. I., Zavoico, G. B., Loscalzo, J., and Maas, A. K. (1987): Synergistic inhibition of platelet activation by plasmin and prostaglandin I2. Blood 69:1504-1507.
31. Vaughan, D. E., Goldhaber, S. Z., Kim, J., and Loscalzo, J. (1987): Recombinant tissue plasminogen activator in patients with pulmonary embolism: correlation of fibrinolytic specificity and efficacy. Circulation 75:1200-1203.
32. Goldhaber, S. Z., Kessler, C. M., Heit, J., Markis, J., Sharma, G. V. R. K., Dawley, D., Nagel, J. S., Meyerovitz, M., Kim, D., Vaughan, D. E., Tumeh, S. S., Loscalzo, J., Selwyn, A. P., and Braunwald, E. (1988): Randomised controlled trial of recombinant tissue plasminogen activator versus urokinase in the treatment of acute pulmonary embolism. Lancet 2:293-298.
33. Goldhaber, S. Z., Vaughan, D. E., Tumeh, S. S., and Loscalzo, J. (1988): Utility of cross- linked fibrin degradation products in the diagnosis of pulmonary embolism. Am. Heart J. 116:505-508.
34. Goldhaber, S. Z. and Loscalzo, J. (1988): Urokinase versus tissue plasminogen activator in pulmonary embolism. Lancet 2:915.
35. Goldhaber, S. Z., Kessler, C. M., Heit, J., Markis, J. E., Sharma, G. V. R. K., Dawley, D. L., Meyerovitz, M. F., Vaughan, D. E., Parker, J. A., Come, P. C., Kim, D., Selwyn, A. P., Loscalzo, J., and Braunwald, E. (1988): Tissue plasminogen activator and acute pulmonary embolism. J. Cell. Biochem. 38:303-312.
36. Loscalzo, J. (1988): Structural and kinetic comparison of recombinant human single- and two-chain tissue plasminogen activator. J. Clin. Invest. 82:1391-1397.
37. Loscalzo, J. (1988): Thrombolytic therapy in acute myocardial infarction. Med. Update 1:1-5.
38. Loscalzo, J. and Braunwald, E. (1988): Tissue plasminogen activator. N.Engl.J.Med. 319:925-931.
39. Loscalzo, J. (1988): When are antiplatelet agents likely to be most effective in treating cardiovascular disease? Choices Cardiol. 2:81-83.
40. Loscalzo, J. and Vaughan, D. E. (1988): Treatment of disorders of cholesterol metabolism. Med. Update 1:1-5.
41. Loscalzo, J. Disorders of lipid metabolism. In Intensive Review of Internal Medicine. C. Fanta and E. Braunwald, eds. Boston: Nimrod Press, pp.334-343, 1988.
42. Mendelsohn, M. E. and Loscalzo, J. (1988): Role of platelets in cholesteryl ester formation by U-937 cells. J. Clin.I nvest. 81:62-68.
43. Stamler, J., Vaughan, D. E., Rudd, M. A., Mudge, G. H., Kirshenbaum, J., Young, P., Alexander, R. W., and Loscalzo, J. (1988): Frequency of hypercholesterolemia after cardiac transplantation. Am. J. Cardiol. 62:1268-1272.
44. Stamler, J., Cunningham, M., and Loscalzo, J. (1988): Reduced thiols and the effect of intravenous nitroglycerin on platelet aggregation. Am. J. Cardiol. 62:377-380.
45. Stamler, J. S., Creager, M. A., Loscalzo, J., and Cooke, J. P. (1988): Vascular response in diabetes with neuropathic foot lesions. N. Engl. J. Med. 319:1155.
46. Vaughan, D. E., Kirshenbaum, J. M., and Loscalzo, J. (1988): Streptokinase-induced, antibody-mediated platelet aggregation: a potential cause of clot propagation in vivo. J. Am. Coll. Cardiol. 11:1343-1348.
47. Cooke, J. P., Andon, N., and Loscalzo, J. (1989): S-nitrosocaptopril. II. Effects on vascular reactivity. J. Pharmacol. Exp. Ther. 249:730-734.
48. Inbal, A. and Loscalzo, J. (1989): Glycocalicin binding to von Willebrand factor adsorbed onto collagen-coated or polystyrene surfaces. Thromb. Res. 56:347-357.
49. Johnstone, M. and Loscalzo, J. (1989): Bleeding with thrombolytic therapy in acute MI. Cardio. Sept.:41-44,132.
50. Kuo, P. C., Rudd, M. A., Nicolosi, R., and Loscalzo, J. (1989): Effect of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of Cebus monkeys. Arteriosclerosis 9:919-927.
51. Loscalzo, J. (1989): Platelets and thrombolysis. J. Vasc. Med. Biol. 1:213-219.
52. Loscalzo, J. Relation between thrombolysis and dietary fat. In Proceedings of the Scientific Conference on the Effects of Dietary Fatty Acids on Serum Lipoproteins and Hemostasis, Washington, D.C., May 23-24, 1989. American Heart Association, pp.161- 167, 1989.
53. Loscalzo, J., Smick, D., Andon, N., and Cooke, J. (1989): S-nitrosocaptopril. I. Molecular characterization and effects on the vasculature and on platelets. J. Pharmacol. Exp. Ther. 249:726-729.
54. Loscalzo, J., Wharton, T. P., Kirshenbaum, J. M., Levine, H. J., Flaherty, J. T., Topol, E. J., Ramaswamy, K., Kosowsky, B. D., Salem, D. N., Ganz, P., Brinker, J. A., Gurewich, V., Muller, J. E., and the Pro-urokinase for Myocardial Infarction Study Group. (1989): Clot-selective coronary thrombolysis with pro-urokinase. Circulation 79:776-782.
55. Loscalzo, J. (1989): Thrombolysis in the management of acute myocardial infarction and unstable angina pectoris. Drugs 37:191-204.
56. Mendelsohn, M. E. and Loscalzo, J. (1989): Low-density lipoprotein and atherogenesis. N. Engl. J. Med. 321:1196 (lett.).
57. Sacks, F. M., Creager, M. A., Gallagher, S. J., Loscalzo, J., and Dzau, V. J. (1989): Effects of alpha- and beta-adrenergic antagonists on plasma apolipoproteins and forearm blood flow in patients with mild hypertension. Am. J. Med. 86:8-13.
58. Schafer, A. I., Rodriguez, R., Loscalzo, J., and Gimbrone, M. A., Jr. (1989): Inhibition of vascular endothelial cell prostacyclin synthesis by plasmin. Blood 74:1015-1020.
59. Stamler, J., Vaughan, D. E., and Loscalzo, J. (1989): Synergistic disaggregation of platelets by tissue-type plasminogen activator, prostaglandin E1, and nitroglycerin. Circ. Res. 65:796-804.
60. Stamler, J., Whittemore, A. D., and Loscalzo, J. (1989): Celiac axis compression syndrome caused by sarcoidosis: an acquired form of the syndrome. Am. J. Med. 86:225- 227.
61. Stamler, J., Mendelsohn, M. E., Amarante, P., Smick, D., Andon, N., Davies, P. F., Cooke, J. P., and Loscalzo, J. (1989): N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ. Res. 65:789-795.
62. Tang, S. S., Loscalzo, J., and Dzau, V. J. (1989): Tissue plasminogen activator activates the renin-angiotensin system in vitro. J. Vasc. Med. Biol. 1:67-74.
63. Vaughan, D. E., Mendelsohn, M. E., Declerck, P. J., Van Houtte, E., Collen, D., and Loscalzo, J. (1989): Characterization of the binding of human tissue-type plasminogen activator to platelets. J. Biol. Chem. 264:15869-15874.
64. Vaughan, D. E. and Loscalzo, J. (1989): Comparative effects of plasminogen activators on platelet disaggregation. J. Vasc. Med. Biol. 1:27-31.
65. Vaughan, D. E., Plavin, S. R., Schafer, A. I., and Loscalzo, J. (1989): PGE1 accelerates thrombolysis by tissue plasminogen activator. Blood 73:1213-1217.
66. Cooke, J. P., Stamler, J., Andon, N. A., Davies, P. F., Mendelsohn, M. E., and Loscalzo, J. Flow-mediated endothelium-dependent effects on platelet and vascular reactivity. In Endothelium-derived Vasoactive Factors. G. M. Rubanyi and P. M. Vanhoutte, eds. Basel: Karger, pp.1-10, 1990.
67. Cooke, J. P., Stamler, J., Andon, N., Davies, P. F., McKinley, G., and Loscalzo, J. (1990): Flow stimulates endothelial cells to release nitrovasodilator that is potentiated by reduced thiol. Am. J. Physiol. 259:H804-H812.
68. Creager, M. A., Cooke, J. P., Mendelsohn, M. E., Gallagher, S. J., Coleman, S. M., Loscalzo, J., and Dzau, V. J. (1990): Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J.Clin.Invest. 86:228-234.
69. Johnstone, M. T., Andrews, T., Ware, J. A., Rudd, M. A., George, D., Weinstein, M., and Loscalzo, J. (1990): Bleeding time prolongation with streptokinase and its reduction with 1-desamino-8-D-arginine vasopressin. Circulation 82:2142-2151.
70. Kuo, P., Weinfeld, M., and Loscalzo, J. (1990): Effect of membrane fatty acyl composition on LDL metabolism in Hep G2 hepatocytes. Biochemistry 29:6626-6632.
71. Kuo, P. C., Weinfeld, M., Rudd, M. A., Amarante, P., and Loscalzo, J. (1990): Plasma membrane enrichment with cis-unsaturated fatty acids enhances LDL metabolism in U937 monocytes. Arteriosclerosis 10:111-118.
72. Loscalzo, J., Fless, G. M., and Scanu, A. M. Lp(a) and the fibrinolytic system. In Lipoprotein(a). A. M. Scanu, eds. San Diego: Academic Press, pp.103-115, 1990.
73. Loscalzo, J. and Amarante, P. (1990): Enhancement of tissue-type plasminogen activator activity by poly-L-lysine. J. Vasc. Med. Biol. 1:336-340.
74. Loscalzo, J. (1990): An overview of thrombolytic agents. Chest 97:117S-123S.
75. Loscalzo, J. (1990): Current issues in thrombolytic therapy for acute myocardial infarction. J. Myocard. Ischemia 1:48-57.
76. Loscalzo, J. (1990): Molecular biologic modification of plasminogen activators. An artful science. Circulation 82:1062-1063.
77. Loscalzo, J. (1990): Regression of coronary atherosclerosis. N. Engl. J. Med. 323:1337- 1339.
78. Loscalzo, J. (1990): Lipoprotein(a). A unique risk factor for atherothrombotic disease. Arteriosclerosis 10:672-679.
79. Loscalzo, J., Weinfeld, M., Fless, G. M., and Scanu, A. M. (1990): Lipoprotein(a), fibrin binding, and plasminogen activation. Arteriosclerosis 10:240-245.
80. Mendelsohn, M. E., O’Neill, S., George, D., and Loscalzo, J. (1990): Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine. J. Biol. Chem. 265:19028-19034.
81. Mendelsohn, M. E. and Loscalzo, J. (1990): Sudden cardiac death. N. Engl. J. Med. 322:271-272.
82. Rudd, M. A., George, D., Amarante, P., Vaughan, D. E., and Loscalzo, J. (1990): Temporal effects of thrombolytic agents on platelet function in vivo and their modulation by prostaglandins. Circ. Res. 67:1175-1181.
83. Simon, D. I. and Loscalzo, J. (1990): Lipoprotein(a) and coronary heart disease in patients with familial hypercholesterolemia. N. Engl. J. Med. 323:1773-1774.
1991
84. Cooke, J. P., Rossitch, E., Jr., Andon, N. A., Loscalzo, J., and Dzau, V. J. (1991): Flow activates an endothelial potassium channel to release endogenous nitrovasodilator. J. Clin. Invest. 88:1663-1671.
85. Ezratty, A. M. and Loscalzo, J. (1991): New approaches to antiplatelet therapy. Blood Coagul. Fibrinolysis 2:317-327.
86. Folts, J. D., Stamler, J., and Loscalzo, J. (1991): Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries. Circulation 83:2122-2127.
87. Handin, R. I. and Loscalzo, J. Hemostasis, thrombosis, fibrinolysis, and cardiovascular disease. In Heart Disease. E. Braunwald, eds. Philadelphia: Saunders, pp.1767-1789, 1991.
88. Kirshenbaum, J. M., Bahr, R. D., Flaherty, J. T., Gurewich, V., Levine, H. J., Loscalzo, J., Schumacher, R. R., Topol, E. J., Wahr, D. W., Braunwald, E., and Pro-Urokinase for Myocardial Infarction Study Group. (1991): Clot-selective coronary thrombolysis with low-dose synergistic combinations of single-chain urokinase-type plasminogen activator and recombinant tissue-type plasminogen activator. Am. J. Cardiol. 68:1564-1569.
89. Loscalzo, J. Lipoprotein(a): a risk factor for atherothrombotic disease. In Heart Disease: Clinical Update. E. Braunwald, eds. Philadelphia: Saunders, pp.10-17, 1991.
90. Loscalzo, J. (1991): L’azione della lipoproteina(a) sulla fibrinolisi. G. Arteriosclerosi 16:29-30.
91. Loscalzo, J. and Braunwald, E. Atherosclerosis. In Video Textbook of Medicine. E. Braunwald, eds. San Francisco: Alpha Telecommunications, pp.1991.
92. Loscalzo, J. (1991): The atherosclerotic process. Prim. Care Newsl. 2:7-10.
93. Loscalzo, J. and Amarante, P. (1991): Enhancement of tissue-type plasminogen activator activity by poly-L-lysine. J. Vasc. Med. Biol. 1:336-340.
94. Newburger, J. W., Burns, J. C., Beiser, A. S., and Loscalzo, J. (1991): Altered lipid profile after Kawasaki syndrome. Circulation 84:625-631.
95. Nicolosi, R. J., Stucchi, A. F., and Loscalzo, J. Effect of dietary fat saturation on low density lipoprotein metabolism. In Health Effects of Dietary Fatty Acids. G. J. Nelson, eds. Champaign, IL: American Oil Chemists’ Society, pp.77-82, 1991.
96. Pasche, B. and Loscalzo, J. (1991): Platelets and fibrinolysis. Platelets 2:125-134.
97. Rabbani, L. E. and Loscalzo, J. (1991): The effects of hyperlipidemia and atherosclerosis on endothelial function and vascular reactivity. Curr. Opin.Lipidology 2:259-265.
98. Rudd, M. A., Johnstone, M. T., Rabbani, L. E., George, D., Ware, J. A., and Loscalzo, J. (1991): Thrombolytic therapy causes an increase in vascular permeability that is reversed by 1-deamino-8-D-vasopressin. Circulation 84:2568-2573.
99. Shaffer, J. E., Lee, F., Thomson, S., Han, B. J., Cooke, J. P., and Loscalzo, J. (1991): The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs. J. Pharmacol. Exp. Ther. 256:704-709.
100. Simon, D. and Loscalzo, J. (1991): Lipoprotein(a): a unique cardiovascular risk factor. J. Cardiovasc. Risk 1:174-178.
101. Simon, D. I., Fless, G. M., Scanu, A. M., and Loscalzo, J. (1991): Tissue-type plasminogen activator binds to and is inhibited by surface-bound lipoprotein(a) and low- density lipoprotein. Biochemistry 30:6671-6677.
102. SOLVD Investigators. (1991): Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N. Engl. J. Med. 325:293-302.
103. Stamler, J. S. and Loscalzo, J. (1991): The antiplatelet effects of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disorders. J. Am. Coll. Cardiol. 18:1529-1536.
104. Stamler, J. S., Vaughan, D. E., and Loscalzo, J. (1991): Immunosuppressive therapy and lipoprotein abnormalities after cardiac transplantation. Am. J. Cardiol. 68:389-391.
105. Stamler, J. S. and Loscalzo, J. (1991): Antithrombotic effects of organic nitrates in cardiovascular disease. Trends Cardiovasc. Med. 1:346-353.
106. Vaughan, D. E. and Loscalzo, J. (1991): New directions in thrombolytic therapy. Molecular mutants and biochemical conjugates. Trends Cardiovasc. Med. 36-39.
107. Bilheimer, D. and Loscalzo, J. (1992): Cardiovascular disease: hyperlipidaemia and coagulation. Editorial overview. Curr. Opin. Lipidology 3:253-256.
108. Ezratty, A. and Loscalzo, J. (1992): Lipoprotein(a): a risk factor with novel mechanisms for the development of atherothrombotic disease. Adv. Endocrinol. Metab. 3:237-256.
109. Jansen, A., Drazen, J., Osborne, J. A., Brown, R., Loscalzo, J., and Stamler, J. S. (1992): The relaxant properties in guinea pig airways of S-nitrosothiols. J. Pharmacol. Exp. Ther. 261:154-160.
110. Loscalzo, J. (1992): The relation between atherosclerosis and thrombosis. Circulation 86:III-95-III-99.
111. Loscalzo, J. (1992): Newest risk factor for atherosclerosis: lipoprotein(a). Cortland Forum 5: 66-67.
112. Loscalzo, J. and Handin, R. I. (1992): Platelet glycocalicin. Methods Enzymol. 215: 289- 294.
113. Loscalzo, J. (1992): Endothelial dysfunction in pulmonary hypertension. N. Engl. J. Med. 327:117-119.
114. Loscalzo, J. and Ezratty, A. Newer antiplatelet agents in acute myocardial infarction. In Adjunctive Therapy for Acute Myocardial Infarction. E. Bates, eds. New York: Marcel Dekker, pp.199-220, 1992.
115. Loscalzo, J. and Rocco, T. P. (1992): Imaging arterial thrombi: an elusive goal. Circulation 85:382-385.
116. Loscalzo, J. (1992): Antiplatelet and antithrombotic effects of organic nitrates. Am. J. Cardiol. 70:18B-22B.
117. Loscalzo, J. (1992): Lipoprotein(a): a lipoprotein particle central to the interface of atherosclerosis and thrombosis. Arteriosclerosis 9:143-146.
118. Loscalzo, J. and Schafer, A. I. Anticoagulants, antiplatelet agents, and fibrinolytics. In Vascular Medicine. J. Loscalzo, M. A. Creager, and V. J. Dzau, eds. Boston: Little, Brown, pp.659-682, 1992.
119. Loscalzo, J. Thrombotic mechanisms in atherogenesis. In Mechanisms of Coronary Disease. Part I: Development of Atherosclerosis and Thrombosis. B. Pitt, eds. New York: Cahners Healthcare Communications, pp.23-27, 1992.
120. McIntyre, K. M., Vita, J. A., Lambrew, C. T., Freedman, J., and Loscalzo, J. (1992): A noninvasive method of predicting pulmonary-capillary wedge pressure. N. Engl. J. Med. 327:1715-1720.
121. Mendelsohn, M. E. and Loscalzo, J. The endotheliopathies. In Vascular Medicine. J. Loscalzo, M. A. Creager, and V. J. Dzau, eds. Boston: Little, Brown, pp.279-305, 1992.
122. Mullins, M. E., Stamler, J. S., Osborne, J. A., Loscalzo, J., and Singel, D. J. (1992): EPR spectroscopic characterization of biological thiyl radicals as PBN spin-trap adducts. Appl. Magnet. Reson. 3:1021-1032.
123. Rudd, M. A., George, D., Johnstone, M. T., Moore, R. T., Collins, L., Rabbani, L. E., and Loscalzo, J. (1992): Effect of thrombin inhibition on the dynamics of thrombolysis and on platelet function during thrombolytic therapy. Circ. Res. 70:829-834.
124. Scharfstein, J. and Loscalzo, J. (1992): Molecular approaches to antithrombotic therapy. Hosp. Pract. 27:77-86.
125. Seed, M. and Loscalzo, J. (1992): Lipoprotein(a) and coronary heart disease. Br. Med. J. 305:472.
126. Simon, D. I. and Loscalzo, J. (1992): Lipoprotein(a): a unique atherothrombotic risk factor. Choices Cardiol. 6:7-9.
127. SOLVD Investigators. (1992): Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fraction. N. Engl. J. Med. 327:685-691.
128. Stamler, J. S., Dzau, V. J., and Loscalzo, J. The smooth muscle cell. In Vascular Medicine. J. Loscalzo, M. A. Creager, and V. J. Dzau, eds. Boston: Little, Brown, pp.79-132, 1992.
129. Stamler, J. S., Simon, D. I., Jaraki, O., Osborne, J. A., Francis, S., Mullins, M., Singel, D., and Loscalzo, J. (1992): S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme. Proc. Natl. Acad. Sci.USA 89:8087-8091.
130. Stamler, J. S. and Loscalzo, J. (1992): Endothelium-derived relaxing factor modulates the atherothrombotic effects of homocysteine. J. Cardiovasc. Pharmacol. 20:S202-S204.
131. Stamler, J. S. and Loscalzo, J. (1992): Capillary zone electrophoretic detection of biological thiols and their S-nitrosated derivatives. Anal. Chem. 64:779-785.
132. Stamler, J. S., Singel, D. J., and Loscalzo, J. (1992): Biochemistry of nitric oxide and its redox-activated forms. Science 258:1898-1902.
133. Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T., Singel, D. J., and Loscalzo, J. (1992): S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc. Natl. Acad. Sci.USA 89:444- 448.
134. Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., and Loscalzo, J. (1992): Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc. Natl. Acad. Sci.USA 89:7674-7677.
135. Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T., Singel, D. J., and Loscalzo, J. Exposure of sulphydryl-containing proteins to nitric oxide and endothelium-derived relaxing factor confers novel bioactivity and modulates their intrinsic functional properties. In The Biology of Nitric Oxide. S. Moncada, M. A. Marletta, J. B. Hibbs, Jr., and E. A. Higgs, eds. London: Portland Press, pp.20-23, 1992.
136. Vaughan, D. E., Schafer, A. I., and Loscalzo, J. Normal mechanisms of hemostasis and fibrinolysis. In Vascular Medicine. J. Loscalzo, M. A. Creager, and V. J. Dzau, eds. Boston: Little, Brown, pp.233-247, 1992.
137. Winther, K., Hillegass, W., Tofler, G. H., Jimenez, A., Brezinski, D. A., Schafer, A. I., Loscalzo, J., Williams, G. H., and Muller, J. E. (1992): Effects of platelet aggregation and fibrinolytic activity during upright position and exercise in healthy men. Am. J. Cardiol. 70:1051-1055.
138. Cannon, C. P., Maraganore, J. M., Loscalzo, J., McAllister, A., Eddings, K., George, D., Selwyn, A. P., Adelman, B., Fox, I., Braunwald, E., and Ganz, P. (1993): Anticoagulant effects of hirulog, a novel thrombin inhibitor, in patients with coronary artery disease. Am. J. Cardiol. 71:778-782.
139. Ezratty, A., Simon, D. I., and Loscalzo, J. (1993): Lipoprotein(a) binds to human platelets and attenuates plasminogen binding and activation. Biochemistry 32:4628-4633.
140. Fernandopulle, R. and Loscalzo, J. Atherosclerosis. In Pathophysiology of Heart Disease. L. Lilly, eds. Malvern, Pa.: Lea & Febiger, pp.84-97, 1993.
141. Gaston, B., Riley, J., Drazen, J. M., Fackler, J., Ramdev, P., Arnelle, D., Mullins, M. E., Sugarbaker, D. J., Chee, C., Singel, D. J., Loscalzo, J., and Stamler, J. S. (1993): Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc. Natl. Acad. Sci.U.S.A. 90:10957-10961.
142. Grevelink, S. A., Youssef, D. E., Loscalzo, J., and Lerner, E. A. (1993): Salivary gland extracts from the deerfly contain a potent inhibitor of platelet aggregation. Proc. Natl. Acad. Sci.USA 90:9155-9158.
143. Keaney, J. F., Jr., Gaziano, J. M., Xu, A., Frei, B., Curran-Celentano, J., Shwaery, G. T., Loscalzo, J., and Vita, J. A. (1993): Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proc. Natl. Acad. Sci.USA 90:11880-11884.
144. Keaney, J. F., Jr., Simon, D. I., Stamler, J. S., Jaraki, O., Scharfstein, J., Vita, J. A., and Loscalzo, J. (1993): NO forms an adduct with serum albumin that has endothelium- derived relaxing factor-like properties. J. Clin. Invest. 91:1582-1589.
145. Keaney, J. F., Jr. and Loscalzo, J. Pharmacology of thrombolytic agents. In Thrombosis and Hemorrhage. J. Loscalzo and A. I. Schafer, eds. Boston: Blackwell, pp.1173-1206, 1993.
146. Kestin, A. S., Valeri, C. R., Khuri, S. F., Loscalzo, J., Ellis, P. A., MacGregor, H., Birjiniuk, V., Ouimet, H., Pasche, B., Nelson, M. J., Benoit, S. E., Rodino, L. J., Barnard, M. R., and Michelson, A. D. (1993): The platelet function defect of cardiopulmonary bypass. Blood 82:107-117.
147. Kuo, P. C., Slivka, A., Wilmore, D., and Loscalzo, J. (1993): Exogenous delivery of nitric oxide: a novel treatment for toxin-mediated hepatocyte injury. Surg. Forum 44:53-55.
148. Lilly, C. M., Stamler, J. S., Gaston, B., Meckel, C., Loscalzo, J., and Drazen, J. M. (1993): Modulation of vasoactive intestinal peptide pulmonary relaxation by NO in tracheally superfused guinea pig lungs. Am. J. Physiol. 265:L410-L415.
149. Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., and Stamler, J. S. (1993): A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso- compounds. Nature 364:626-632.
150. Loscalzo, J. (1993): The induction of cellular interactions in atherogenesis and their modulation. Biochem. Soc. Trans. 21:656-659.
151. Loscalzo, J. (1993): Thrombotic determinants of macrophage foam-cell formation. Atherosclerosis Rev. 25:39-47.
152. Loscalzo, J. and Sniderman, A. (1993): Cardiovascular disease and hyperlipidaemia: editorial overview. Curr. Opin. Lipidology 4:273-276.
153. Loscalzo, J. Hyperlipoproteinemia. In Current Pediatric Therapy. eds. Philadelphia: Saunders, pp.331-333, 1993.
154. Mendelsohn, M. E. and Loscalzo, J. The endotheliopathies: endothelial dysfunction in clinical disorders. In Thrombosis and Hemorrhage. J. Loscalzo and A. I. Schafer, eds. Boston: Blackwell, pp.861-882, 1993.
155. Ouimet, H. and Loscalzo, J. Fibrinolysis. In Thrombosis and Hemorrhage. J. Loscalzo and A. I. Schafer, eds. Boston: Blackwell, pp.127-144, 1993.
156. Ouimet, H. and Loscalzo, J. (1993): Reciprocating autocatalytic interactions between platelets and the plasminogen activation system. Thromb. Res. 70:355-364.
157. Rabbani, L. E. and Loscalzo, J. (1993): Atherothrombotic insights into secondary prevention after acute myocardial infarction. Can. J. Cardiol. 9:739-747.
158. Rabbani, L. E., Johnstone, M. T., Rudd, M. A., Devine, P., George, D., and Loscalzo, J. (1993): PPACK attenuates plasmin-induced changes in endothelial integrity. Thromb. Res. 70:425-436.
159. Rabbani, L. E. and Loscalzo, J. The relationship between atherosclerosis and thrombosis. In Thrombosis and Hemorrhage. J. Loscalzo and A. I. Schafer, eds. Boston: Blackwell, pp.769-790, 1993.
160. Rachmilewitz, D., Stamler, J. S., Karmeli, F., Mullins, M. E., Singel, D. J., Loscalzo, J., Xavier, R. J., and Podolsky, D. K. (1993): Peroxynitrite-induced rat colitis--a new model of colonic inflammation. Gastroenterology 105:1681-1688.
161. Rovin, J. D., Stamler, J. S., Loscalzo, J., and Folts, J. D. (1993): Sodium nitroprusside, an endothelium-derived relaxing factor congener, increases platelet cyclic GMP levels and inhibits epinephrine-exacerbated in vivo platelet thrombus formation in stenosed canine coronary arteries. J. Cardiovasc. Pharmacol. 22:626-631.
162. Scharfstein, J. S., Gold, H. K., and Loscalzo, J. New antithrombotic strategies. In Thrombosis and Hemorrhage. J. Loscalzo and A. I. Schafer, eds. Boston: Blackwell, pp.1207-1224, 1993.
163. Sharma, G. V. R. K., Lapsley, D., Vita, J. A., Sharma, S., Coccio, E., Adelman, B., and Loscalzo, J. (1993): Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris. Am. J. Cardiol. 72:1357-1360.
164. Simon, D. I., Ezratty, A. M., and Loscalzo, J. (1993): Lipoprotein(a) and atherothrombosis. Curr. Opin. Cardiol. 8:814-820.
165. Simon, D. I., Stamler, J. S., Jaraki, O., Keaney, J. F., Osborne, J. A., Francis, S. A., Singel, D. J., and Loscalzo, J. (1993): Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. Arterioscler. Thromb. 13:791- 799.
166. Simon, D. I., Ezratty, A. M., Francis, S. A., Rennke, H., and Loscalzo, J. (1993): Fibrin(ogen) is internalized and degraded by activated human monocytoid cells via Mac-1 (CD11b/CD18): a nonplasmin fibrinolytic pathway. Blood 82:2414-2422.
167. Stamler, J. S., Osborne, J. A., Jaraki, O., Rabbani, L. E., Mullins, M., Singel, D., and Loscalzo, J. (1993): Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J. Clin. Invest. 91:308-318.
168. Burchenal, J. E. and Loscalzo, J. (1994): Endothelial dysfunction and pulmonary hypertension. Prim. Cardiol. 20:28-32.
169. Cannon, C. P., McCabe, C. H., Henry, T. D., Schweiger, M. J., Gibson, R. S., Mueller, H. S., Becker, R. C., Kleiman, N. S., Haugland, J. M., Anderson, J. L., Sharaf, B. L., Edwards, S. J., Rogers, W. J., Williams, D. O., Braunwald, E., and and the TIMI Investigators. (1994): A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction--results of the Thrombolysis in Myocardial Infarction (TIMI) 5 Trial. J. Am. Coll. Cardiol. 23:993-1003.
170. Cannon, C. P., McCabe, C. H., Diver, D. J., Herson, S., Greene, R. M., Shah, P. K., Sequeira, R. F., Leya, F., Kirshenbaum, J. M., Magorien, R. D., Palmeri, S. T., Davis, V., Gibson, C. M., Poole, W. K., Braunwald, E., and and the TIMI 4 Investigators. (1994): A comparison of front-loaded recombinant tissue-type plasminogen activator, anistreplase, and combination thrombolytic therapy for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 4 Trial. J. Am. Coll. Cardiol. 24:1602-1610.
171. Flaker, G. C., Bartolozzi, J., Davis, V., McCabe, C., Cannon, C. P., and for the TIMI 4 Investigators. (1994): Use of a standardized heparin nomogram to achieve therapeutic anticoagulation after thrombolytic therapy in myocardial infarction. Arch. Intern. Med. 154:1492-1496.
172. Gaston, B., Drazen, J. M., Jansen, A., Sugarbaker, D. A., Loscalzo, J., Richards, W., and Stamler, J. S. (1994): Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro. J. Pharmacol. Exp. Ther. 268:978-984.
173. Gaston, B., Drazen, J. M., Lilly, C., Sugarbaker, D. A., Loscalzo, J., and Stamler, J. S. Bioactive oxides of nitrogen in the lung: immunity and the neural axis. In Nitric Oxide: Brain and Immune System. eds. London: Portland Press, pp.265-276, 1994.
174. Gaston, B., Drazen, J. M., Loscalzo, J., and Stamler, J. S. (1994): The biology of nitrogen oxides in the airways. Am. J. Respir. Crit. Care.Med. 149:538-551.
175. Jaraki, O., Strauss, W. E., Francis, S., Loscalzo, J., and Stamler, J. S. (1994): Antiplatelet effects of a novel antianginal agent, nicorandil. J. Cardiovasc. Pharmacol. 23:24-30.
176. Keaney, J. F., Jr., Shwaery, G. T., Xu, A., Nicolosi, R. J., Loscalzo, J., Foxall, T. J., and Vita, J. A. (1994): 17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Circulation 89:2251- 2259.
177. Keaney, J. F., Jr., Gaziano, J. M., Xu, A., Frei, B., Curran-Celentano, J., Shwaery, G. T., Loscalzo, J., and Vita, J. A. (1994): Low-dose alpha-tocopheral improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. J. Clin. Invest. 93:844-851.
178. Keaney, J. F., Jr., Puyana, J. C., Francis, S., Loscalzo, J. F., Stamler, J. S., and Loscalzo, J. (1994): Methylene blue reverses endotoxin-induced hypotension. Circ. Res. 74:1121-1125.
179. Loh, E., Stamler, J. S., Hare, J. M., Loscalzo, J., and Colucci, W. S. (1994): Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation 90:2780-2785.
180. Loscalzo, J. and Vita, J. A. (1994): Ischemia, hyperemia, exercise, and nitric oxide. Complex physiology and complex molecular adaptations. Circulation 90:2556-2559.
181. Michelson, A. D., Barnard, M. R., Valeri, C. R., Khuri, S. F., Loscalzo, J., and Kestin, A. S. (1994): Platelet aggregation abnormalities after cardiopulmonary bypass. Blood 83:300-301.
182. Ouimet, H., Freedman, J. E., and Loscalzo, J. (1994): Kinetics and mechanism of platelet- surface plasminogen activation by tissue-type plasminogen activator. Biochemistry 33:2970-2976.
183. Pasche, B., Ouimet, H., Francis, S., and Loscalzo, J. (1994): Structural changes in platelet glycoprotein IIb/IIIa by plasmin: determinants and functional consequences. Blood 83:404-414.
184. Rabbani, L. E. and Loscalzo, J. (1994): Recent observations on the role of hemostatic determinants in the development of the atherothrombotic plaque. Atherosclerosis 105:1-7.
185. Rabbani, L. E., Edelman, E. R., Ganz, P., Selwyn, A. P., Loscalzo, J., and Bittl, J. A. (1994): Relation of restenosis after excimer laser angiography to fasting insulin levels. Am. J. Cardiol. 73:323-327.
186. Scharfstein, J. S., Keaney, J. F., Jr., Slivka, A., Welch, G. N., Vita, J. A., Stamler, J. S., and Loscalzo, J. (1994): In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. J. Clin. Invest. 94 :1432-1439.
187. Schaub, R. G., Bree, M. P., Hayes, L. L., Rudd, M. A., Rabbani, L., Loscalzo, J., and Clinton, S. K. (1994): Recombinant human macrophage colony-stimulating factor reduces plasma cholesterol and carrageenan granuloma foam cell formation in Watanabe heritable hyperlipidemic rabbits. Arterioscler. Thromb. 14:70-76.
188. Simon, D. I., Ezratty, A. M., and Loscalzo, J. (1994): The fibrin(ogen)olytic properties of cathepsin D. Biochemistry 33:6555-6563.
189. Slivka, A., Chuttani, R., Carr-Locke, D. L., Kobzik, L., Bredt, D. S., Loscalzo, J., and Stamler, J. S. (1994): Inhibition of sphincter of Oddi function by the nitric oxide carrier S-nitroso-N-acetylcysteine in rabbits and humans. J. Clin. Invest. 94:1792-1798.
190. Welch, G. and Loscalzo, J. (1994): Nitric oxide and the cardiovascular system. J. Card. Surg. 9:361-371.
191. Ezratty, A., Freedman, J. E., Simon, D., and Loscalzo, J. (1995): The antithrombotic effects of acetylation of fibrinogen by aspirin. J. Vasc. Med. Biol. 5:152-159.
192. Freedman, J. E., Frei, B., Welch, G. N., and Loscalzo, J. (1995): Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols. J. Clin. Invest. 96:394- 400.
193. Freedman, J. E., Fabian, A., and Loscalzo, J. (1995): Impaired EDRF production by endothelial cells exposed to fibrin monomer and FDP. Am. J. Physiol. 268:C520-C526.
194. Grevelink, S. A., Osborne, J., Loscalzo, J., and Lerner, E. A. (1995): Vasorelaxant and second messenger effects of maxadilan. J. Pharmacol. Exp. Ther. 272:33-37.
195. Hare, J. M., Keaney, J. F., Jr., Balligand, J.-L., Loscalzo, J., Smith, T. W., and Colucci, W. S. (1995): Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. J. Clin. Invest. 95:360-366.
196. Khuri, S. F., Valeri, C. R., Loscalzo, J., Weinstein, M. J., Birjiniuk, V., Healey, N. A., MacGregor, H., Doursounian, M., and Zolkewitz, M. A. (1995): Heparin causes platelet dysfunction and induces fibrinolysis before cardiopulmonary bypass. Ann. Thorac. Surg. 60:1008-1014.
196. Lee, V. L. (1995): Initial experience with hirudin and streptokinase in acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 6 Trial. Am. J. Cardiol. 75:7-13.
197. Leopold, J. A. and Loscalzo, J. (1995): Platelet activation by fibrinolytic agents: a potential mechanism for resistance to thrombolysis and reocclusion after successful thrombolysis. Coron. Artery Dis. 6:923-929.
199. Levine, G. N., Chodos, A. P., and Loscalzo, J. (1995): Restenosis following coronary angioplasty: clinical presentations and therapeutic options. Clin. Cardiol. 18:693-703.
200. Levy, A. P., Levy, N. S., Loscalzo, J., Calderone, A., Takahashi, N., Yeo, K. T., Koren, G., Colucci, W. S., and Goldberg, M. A. (1995): Regulation of vascular endothelial growth factor in cardiac myocytes. Circ. Res. 76:758-766.
201. Loscalzo, J. (1995): Nitric oxide and vascular disease. N. Engl. J. Med. 333:251-253.
202. Loscalzo, J. Pathogenesis of thrombosis. In Williams Hematology. E. Beutler, M. A. Lichtman, and B. S. Coller, eds. Philadelphia: Saunders, pp.1525-1530, 1995.
203. Loscalzo, J. (1995): Endothelial injury, vasoconstriction, and its prevention. Tex. Heart Inst. J. 22:180-184.
204. Loscalzo, J. Fibrinolytic therapy. In Williams Hematology. E. Beutler, M. A. Lichtman, and B. S. Coller, eds. Philadelphia: Saunders, pp.1585-1591, 1995.
205. Loscalzo, J. Hyperlipoproteinemia. In Gellis & Kagan’s Current Pediatric Therapy. F. D. Burg, J. R. Ingelfinger, and E. R. Wald, eds. Philadelphia: Saunders, pp.377-380, 1995.
206. Loscalzo, J. and Welch, G. (1995): Nitric oxide and its role in the cardiovascular system. Prog. Cardiovasc. Dis. 38:87-104.
207. Loscalzo, J., Pasche, B., Ouimet, H., and Freedman, J. E. (1995): Platelets and plasminogen activation. Thromb. Haemost. 74:291-293.
208. Loscalzo, J. (1995): Book Review: Prevention of Venous Thromboembolism, by D. Bergqvist. Circulation 91:1896.
209. Marks, D. and Loscalzo, J. Vasoreactive disease: molecular approach. In Molecular Interventions and Local Drug Delivery in Cardiovascular Diseases. E. R. Edelman, eds. Philadelphia: Saunders, pp.213-232, 1995.
210. Marks, D. S., Vita, J. A., Folts, J. D., Keaney, J. F., Jr., Welch, G. N., and Loscalzo, J. (1995): Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide. J. Clin. Invest. 96:2630-2638.
211. Nanji, A. A., Greenberg, S. S., Tahan, S. R., Fogt, F., Loscalzo, J., Sadrzadeh, S. M. H., Xie, J. M., and Stamler, J. S. (1995): Nitric oxide production in experimental alcoholic liver disease in the rat: Role in protection from injury. Gastroenterology 109:899-907.
212. Schubert, P. J. and Loscalzo, J. (1995): Antithrombotic therapy. Compr. Ther. 21:344- 350.
213. Simon, D. I., Stamler, J. S., Loh, E., Loscalzo, J., Francis, S. A., and Creager, M. A. (1995): Effect of nitric oxide synthase inhibition on bleeding time in humans. J. Cardiovasc. Pharmacol. 26:339-342.
214. Upchurch, G. R., Jr., Welch, G. N., and Loscalzo, J. (1995): S-nitrosothiols: chemistry, biochemistry, and biological actions. Adv. Pharmacol. 34:343-349.
215. Vaughan, D. E., Passamani, E. R., and Loscalzo, J. Tissue-type plasminogen activator in acute myocardial infarction. In Coronary Care. J. Alpert and G. Francis, eds. Boston: Little, Brown, pp.443-450, 1995.
216. Welch, G. N., Upchurch, G. R., Jr., and Loscalzo, J. (1995): Nitric oxide as a vascular modulator. Blood Rev. 9:262-269.
217. Zarich, S. W., Kowalchuk, G. J., Weaver, W. D., Loscalzo, J., Sassower, M., Manzo, K., Byrnes, C., Muller, J. E., and Gurewich, V. (1995): Sequential combination thrombolytic therapy for acute myocardial infarction: results of the Pro-Urokinase and t-PA Enhancement of Thrombolysis (PATENT) Trial. J. Am. Coll. Cardiol. 26:374-379.
218. Dobroski, D. R. and Loscalzo, J. (1996): Thrombotic risk factors for atherosclerosis. Coron. Artery Dis. 7:919-932.
219. Freedman, J. E., Farhat, J. H., Loscalzo, J., and Keaney, J. F., Jr. (1996): Alpha- tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 94:2434-2440.
220. Freedman, J. E. and Loscalzo, J. Arterial and venous thrombotic diseases: thrombolytic and antithrombotic therapies. In Cardiovascular Therapeutics. T. W. Smith, eds. Philadelphia: Saunders, pp.470-481, 1996.
221. Freedman, J. E., Loscalzo, J., Benoit, S. E., Valeri, C. R., Barnard, M. R., and Michelson, A. D. (1996): Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis. J. Clin. Invest. 97:979-987.
222. Fuster, V., Gotto, A. M., Jr., Libby, P., Loscalzo, J., and McGill, H. C., Jr. (1996): 27th Bethesda Conference: matching the intensity of risk factor management with the hazard of coronary disease events. Task force 1. Pathogenesis of coronary disease: the biologic role of risk factors. J. Am. Coll. Cardiol. 27:964-976.
223. Gokce, N. and Loscalzo, J. (1996): Are newer antithrombotic drugs better than aspirin following angioplasty? Cardiol. Rev. 4:271-277.
224. Jackson, T. S., Lerner, E., Weisbrod, R. M., Tajima, M., Loscalzo, J., and Keaney, J. F., Jr. (1996): Vasodilatory properties of recombinant maxadilan. Am. J.P hysiol. Heart Circ. Physiol. 271:H924-H930.
225. Keaney, J. F., Jr., Hare, J. M., Balligand, J. L., Loscalzo, J., Smith, T. W., and Colucci, W. S. (1996): Inhibition of nitric oxide synthase augments myocardial contractile responses to b-adrenergic stimulation. Am. J. Physiol. Heart Circ. Physiol. 271:H2646- H2652.
226. Khuri, S. F., Valeri, C. R., Loscalzo, J., and Michelson, A. D. (1996): Heparin effect on platelets and fibrinolysis - Reply. Ann. Thorac. Surg. 61:1590-1591.
227. Loscalzo, J. (1996): Thrombin inhibitors in fibrinolysis. A Hobson’s choice of alternatives. Circulation 94:863-865.
228. Loscalzo, J. (1996): Nitric oxide and restenosis. Clin. Appl. Thromb. Hemost. 2:7-10.
229. Loscalzo, J. and Radomski, M. W. Platelet bioassays of nitric oxide and related congeners. In Methods in Nitric Oxide Research. M. Feelisch and J. S. Stamler, eds. Chichester,U.K.: John Wiley & Sons, Ltd., pp.584-591, 1996.
230. Loscalzo, J. (1996): The macrophage and fibrinolysis. Semin. Thromb. Hemost. 22:503- 506.
231. Loscalzo, J. and Schafer, A. I. Anticoagulants, antiplatelet agents, and fibrinolytics. In Vascular Medicine. J. Loscalzo, M. A. Creager, and V. J. Dzau, eds. Boston: Little, Brown, pp.639-664, 1996.
232. Loscalzo, J. (1996): The oxidant stress of hyperhomocyst(e)inemia. J. Clin.I nvest. 98 :5- 7.
233. Michelson, A. D., Barnard, M. R., Hechtman, H. B., MacGregor, H., Connolly, R. J., Loscalzo, J., and Valeri, C. R. (1996): In vivo tracking of platelets: Circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function. Proc. Natl. Acad. Sci.USA 93:11877-11882.
234. Michelson, A. D., Benoit, S. E., Furman, M. I., Breckwoldt, W. L., Rohrer, M. J., Barnard, MR, and Loscalzo, J. (1996): Effects of nitric oxide/EDRF on platelet surface glycoproteins. Am. J. Physiol. 270:H1640-8.
235. Philippides, G. J. and Loscalzo, J. (1996): Potential adavantages of direct-acting thrombin inhibitors. Coron. Artery Dis. 7:497-507.
236. Scharfstein, J. S., Abendschein, D. R., Eisenberg, P. R., George, D., Cannon, C. P., Becker, R. C., Sobel, B., Cupples, L. A., Braunwald, E., Loscalzo, J., and for the TIMI-5 Investigators. (1996): Usefulness of fibrinogenolytic and procoagulant markers during thrombolytic therapy in predicting clinical outcomes in acute myocardial infarction. Am. J. Cardiol. 78:503-510.
237. Sherman, D. L., Upchurch, G. R., Jr., and Loscalzo, J. Alcohol and endothelial cell dysfunction. In Alcohol and the Cardiovascular System. S. Zakhari and M. Wassef, eds. Bethesda: NIH, pp.567-589, 1996.
238. Stamler, J. S., Dzau, V. J., and Loscalzo, J. The smooth muscle cell. In Vascular Medicine. J. Loscalzo, M. A. Creager, and V. J. Dzau, eds. Boston: Little, Brown, pp.69- 116, 1996.
239. Upchurch, G. R., Welch, G. N., and Loscalzo, J. (1996): The vascular biology of S- nitrosothiols, nitrosated derivatives of thiols. Vasc. Med. 1:25-33.
240. Upchurch, G. R., Valeri, C. R., Khuri, S. F., Rohrer, M. J., Welch, G. N., MacGregor, H., Ragno, G., Francis, S., Rodino, L. J., Michelson, A. D., and Loscalzo, J. (1996): Effect of heparin on fibrinolytic activity and platelet function in vivo. Am. J. Physiol. 271:H528- 34.
241. Upchurch, G. R., Jr., Welch, G. N., and Loscalzo, J. (1996): Homocysteine, EDRF, and endothelial function. J. Nutr. 126:1290S-1294S.
242. Vaughan, D. E., Schafer, A. I., and Loscalzo, J. Normal mechanisms of hemostasis and fibrinolysis. In Vascular Medicine. J. Loscalzo, M. A. Creager, and V. J. Dzau, eds. Boston: Little, Brown, pp.207-216, 1996.
243. Vita, J. A., Keaney, J. F., Jr., and Loscalzo, J. Endothelial dysfunction in vascular disease. In Vascular Medicine. J. Loscalzo, M. A. Creager, and V. J. Dzau, eds. Boston: Little, Brown, pp.245-264, 1996.
244. Welch, G. N., Upchurch, G. R., Jr., and Loscalzo, J. (1996): S-nitrosothiol detection. Methods Enzymol. 268:293-298.
245. Welch, G. N., Upchurch, G. R., Jr., and Loscalzo, J. (1996): Detection of S-nitrosothiols. Methods Neurosci. 31:34-40.
246. Zhang, Y. and Loscalzo, J. (1996): Nitrosation of proteins. Methods Neurosci. 31:41-46.
247. Zhang, Y. Y., Xu, A. M., Nomen, M., Walsh, M., Keaney, J. F., Jr., and Loscalzo, J. (1996): Nitrosation of tryptophan residue(s) in serum albumin and model dipeptides. Biochemical characterization and bioactivity. J. Biol. Chem. 271:14271-14279.
248. Alpert, C., Ramdev, N., George, D., and Loscalzo, J. (1997): Detection of S-nitrosothiols and other nitric oxide derivatives by photolysis-chemiluminescence spectrometry. Anal. Biochem. 245:1-7.
249. Ekery, D. L. and Loscalzo, J. (1997): Homocysteine and coronary atherosclerosis. Cardiol. Gen. Pract. 2:8-12.
250. Welch, G. N., Upchurch, G. R., Jr., and Loscalzo, J. (1997): Homocysteine, oxidative stress, and vascular disease. Hospital Practice (Office Edition) 32:81-82.
251. Freedman, J. E. and Loscalzo, J. (1997): The role of platelets in coronary heart disease. UpToDate 5:1-5.
252. Freedman, J. E., Loscalzo, J., Barnard, M. R., Alpert, C., Keaney, J. F., Jr., and Michelson, A. D. (1997): Nitric oxide released from activated platelets inhibits platelet recruitment. J. Clin. Invest. 100:350-356.
253. Freedman, J. E. and Loscalzo, J. (1997): Endothelial dysfunction and atherothrombotic occlusive disease. Drugs 54 Suppl 3:41-49.
254. Kuo, P. C., Schroeder, R. A., and Loscalzo, J. (1997): Nitric oxide and acetaminophen- mediated oxidative injury: Modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. J. Pharmacol. Exp. Ther. 282:1072-1083.
255. Kuo, P. C., Slivka, A., and Loscalzo, J. Nitric oxide regulates glutathione metabolism in hepatocyte oxidative stress. In Immune Consequences of Trauma, Shock and Sepsis: Mechanisms and Therapeutic Approaches. A. Faist, A. E. Baue, and F. W. Schildberg, eds. Lengerich, Germany: Pabst Science, pp.667-672, 1997.
256. Leopold, J. A. and Loscalzo, J. (1997): New developments in nitrovasodilator therapy. Vasc. Med. 2:190-202.
257. Loscalzo, J. (Section Ed., Vascular Biology and Physiology). In Textbook of Coronary Thrombosis and Thrombolysis. R. C. Becker, eds. Boston: Kluwer, pp.1997.
258. Loscalzo, J. (1997): Nitric oxide binding and the adverse effects of cell-free hemoglobins: What makes us different from earthworms. J. Lab. Clin. Med. 129:580-583.
259. Loscalzo, J. and Schafer, A. I. Overview of hemostasis and fibrinolysis. In New Therapeutic Agents in Thrombosis and Thrombolysis. A. A. Sasahara and J. Loscalzo, eds. New York: Marcel Dekker, pp.1-7, 1997.
260. Loscalzo, J. (1997): The narrow therapeutic index of thrombin inhibition: implications for newer antithrombotic therapies. J. Thromb. Thrombolysis 4:315-316.
261. Loscalzo, J. Nitric oxide and hemostasis. In Coronary Microcirculation during Ischaemia and Reperfusion. S. Haunso, J. Aldershvile, and J. H. Svendsen, eds. Copenhagen: Munksgaard, pp.142-150, 1997.
262. Moraes, D. and Loscalzo, J. (1997): Pulmonary hypertension: newer concepts in diagnosis and management. Clin. Cardiol. 20:676-682.
263. Orlandi, Q. and Loscalzo, J. Adhesion molecules in atherosclerosis. In Adhesion Molecules in Health and Disease . L. C. Paul and T. B. Issekutz, eds. New York: Marcel Dekker, pp.401-425, 1997.
264. Robinson, K. and Loscalzo, J. Other risk factors for coronary artery disease: homocysteine, lipoprotein(a), fibrinogen, and plasminogen activator inhibitor. In Textbook of Cardiovascular Medicine. E. J. Topol, eds. Philadelphia: Lippincott-Raven, pp.231-247, 1997.
265. Sherman, D. L. and Loscalzo, J. (1997): Endothelial dysfunction and cardiovascular disease. Cardiologia. 42:177-187.
266. Upchurch, G. R., Jr., Welch, G. N., Fabian, A. J., Pigazzi, A., Keaney, J. F., Jr., and Loscalzo, J. (1997): Stimulation of endothelial nitric oxide production by homocyst(e)ine. Atherosclerosis 132:177-185.
267. Upchurch, G. R., Jr., Loscalzo, J., and Banes, A. J. (1997): Changes in the amplitude of cyclic load biphasically modulate endothelial cell DNA synthesis and division. Vasc. Med. 2:19-24.
268. Upchurch, G. R., Jr., Welch, G. N., Fabian, A. J., Freedman, J. E., Johnson, J. L., Keaney, J. F., Jr., and Loscalzo, J. (1997): Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J. Biol. Chem. 272:17012-17017.
269. Upchurch, G. R., Jr., Welch, G. N., Freedman, J. E., Fabian, A. J., Pigazzi, A., Scribner, A. M., Alpert, C. S., Keaney, J. F., Jr., and Loscalzo, J. (1997): High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells. Circulation 95:2115-2121.
270. Welch, G. N., Upchurch, G., Jr., and Loscalzo, J. (1997): Hyperhomocyst(e)inemia and atherothrombosis. Ann. N. Y. Acad. Sci. 811:48-59.
271. Zhao, Z. H., Francis, C. E., Welch, G., Loscalzo, J., and Ravid, K. (1997): Reduced glutathione prevents nitric oxide-induced apoptosis in vascular smooth muscle cells. Biochim. Biophys. Acta Mol. Cell Res. 1359:143-152.
272. Cannon, C. P. and Loscalzo, J. Thrombolytic and antithrombotic therapies for acute coronary syndromes. In Contemporary Concepts in Cardiology. R. Gorlin, P. Toutouzas, G. D. Dangas, and M. M. Konstadoulakis, eds. Norwell, MA: Kluwer, pp.142-175, 1998.
273. Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J., Zimmerman, G. A., McEver, R. P., Pober, J. S., Wick, T. M., Konkle, B. A., Schwartz, B. S., Barnathan, E. S., McCrae, K. R., Hug, B. A., Schmidt, A. M., and Stern, D. M. (5-15-1998): Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91:3527-3561.
274. Dobroski, D. R., Rabbani, L. E., and Loscalzo, J. The relationship between thrombosis and atherosclerosis. In Thrombosis and Hemorrhage. J. Loscalzo and A. I. Schafer, eds. Baltimore: Williams & Wilkins, pp.837-861, 1998.
275. Eberhardt, R. T. and Loscalzo, J. (1998): Effect of cardiac drugs on platelet function. UpToDate 6:1-10.
276. Freedman, J. and Loscalzo, J. Platelets and fibrinolysis/thrombosis. In Fibrinolysis in Disease. P. Glas-Greenwalt, eds. New York: CRC Press, pp.1998.
277. Freedman, J. E., Scharfstein, J. S., and Gold, H. K. New antithrombotic strategies. In Thrombosis and Hemorrhage. J. Loscalzo and A. I. Schafer, eds. Baltimore: Williams & Wilkins, pp.1259-1277, 1998.
278. Freedman, J. E., Ting, B., Hankin, B., Loscalzo, J., Keaney, J. F., Jr., and Vita, J. A. (1998): Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation 98:1481-1486.
279. Leopold, J. A., Keaney, J. F., Jr., and Loscalzo, J. Pharmacology of thrombolytic agents. In Thrombosis and Hemorrhage. J. Loscalzo and A. I. Schafer, eds. Baltimore: Williams & Wilkins, pp.1215-1258, 1998.
280. Liu, Z. G., Rudd, M. A., Freedman, J. E., and Loscalzo, J. (1998): S-transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide. J. Pharmacol. Exp. Ther. 284:526-534.
281. Loscalzo, J. (1998): Hemostasis and fibrinolysis. Thrombolysis Update 1:1-3.
282. Loscalzo, J. The antithrombotic effects of nitric oxide. In Vascular Endothelium: Pharmacologic and Genetic Manipulation. J. D. Catravas, A. Callow, and U. Ryan, eds. New York: Plenum Press, pp.99-102, 1998.
283. Loscalzo, J. Nitric oxide: biological and medical implications. In Harrison’s Principles of Internal Medicine. A. S. Fauci, E. Braunwald, K. J. Isselbacher, J. D. Wilson, J. B. Martin, D. L. Kasper, S. L. Hauser, and D. L. Longo, eds. New York: McGraw-Hill, pp.442-444, 1998.
284. Moraes, D. and Loscalzo, J. (1998): Pulmonary hypertension. Drugs of Today 34:855- 864.
285. Sharis, P. J., Cannon, C. P., and Loscalzo, J. (1998): The antiplatelet effects of ticlopidine and clopidogrel. Ann. Intern. Med. 129:394-405.
286. Upchurch, G. R., Jr., Leopold, J. A., Welch, G. N., and Loscalzo, J. (1998): Nitric oxide alters human microvascular endothelial cell response to cyclic strain. J. Cardiovasc. Pharmacol. Therapeut. 3:135-142.
287. Upchurch, G. R., Jr., Ramdev, N., Walsh, M. T., and Loscalzo, J. (1998): Prothrombotic consequences of the oxidation of fibrinogen and their inhibition by aspirin. J. Thromb. Thrombolysis 5:9-14.
288. Valeri, C. R., Crowley, J. P., and Loscalzo, J. (1998): The red cell transfusion trigger: has a sin of commission now become a sin of omission?. Transfusion 38:602-610.
289. Welch, G. N., Upchurch, G. R., Jr., and Loscalzo, J. Fibrinolysis. In Cardiac Intensive Care. D. L. Brown, eds. Philadelphia: Saunders, pp.83-90, 1998.
290. Welch, G. N., Upchurch, G. R., Jr., Farivar, R. S., Pigazzi, A., Vu, K., Brecher, P., Keaney, J. F., Jr., and Loscalzo, J. (1998): Homocysteine-induced nitric oxide production in vascular smooth-muscle cells by NF-kappa B-dependent transcriptional activation of Nos2. Proc. Assoc. Am. Physicians. 110:22-31.
291. Welch, G. N. and Loscalzo, J. (1998): Homocysteine and atherothrombosis. N. Engl. J. Med. 338:1042-1050.
292. Battinelli, E. M., Trolliet, M. R., and Loscalzo, J. Nitric oxide and its role in hemostasis. In Pathophysiology and Clinical Applications of Nitric Oxide, Part B. G. M. Rubanyi, eds. Australia: Harwood Academic Publishing, pp.229-249, 1999.
293. Biegelsen, E. S. and Loscalzo, J. (1999): Endothelial function and atherosclerosis. Coron. Artery Dis. 10:241-256.
294. Farber, H. W. and Loscalzo, J. (1999): Prothrombotic mechanisms in primary pulmonary hypertension. J. Lab. Clin. Med. 134:561-566.
295. Folts, J. D., Schafer, A. I., Loscalzo, J., Willerson, J. T., and Muller, J. E. (1999): A perspective on the potential problems with aspirin as an antithrombotic agent: A comparison of studies in an animal model with clinical trials. J. Am. Coll.C ardiol. 33:295-303.
296. Freedman, J. E., Sauter, R., Battinelli, E. M., Ault, K., Knowles, C., Huang, P. L., and Loscalzo, J. (1999): Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ. Res. 84:1416-1421.
297. Hammerman, S. I., Klings, E. S., Hendra, K. P., Upchurch, G. R., Rishikof, D. C., Loscalzo, J., and Farber, H. W. (1999): Endothelial cell nitric oxide production in acute chest syndrome. Am. J. Physiol. 277:H1579-H1592.
298. Inbal, A., Gurevitz, O., Tamarin, I., Eskaraev, R., Chetrit, A., Novicov, I., Feldman, M., Varon, D., Eldar, M., and Loscalzo, J. (9-1-1999): Unique antiplatelet effects of a novel S-nitrosoderivative of a recombinant fragment of von Willebrand factor, AR545C: In vitro and ex vivo inhibition of platelet function. Blood 94:1693-1700.
299. Keaney, J. F., Jr. and Loscalzo, J. (1999): Diabetes, oxidative stress, and platelet activation. Circulation 99:189-191.
300. Kenet, G., Freedman, J., Shenkman, B., Regina, E., Brok-Simoni, F., Holzman, F., Vavva, F., Brand, N., Michelson, A., Trolliet, M., Loscalzo, J., and Inbal, A. (1999): Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke. Arterioscl. Thromb. Vasc. Biol. 19:2017-2023.
301. Leopold, J. A. and Loscalzo, J. Platelets and fibrinolysis. In Platelets, Thrombosis and the Vessel Wall. M. C. Berndt, eds. Reading: Gordon & Breach, pp.1999.
302. Leopold, J. A. and Loscalzo, J. Vascular smooth muscle cell biology and restenosis. In Applications of Antisense Therapies to Restenosis. L. E. Rabbani, eds. Boston: Kluwer, pp.45-69, 1999.
303. Lieberthal, W., Fuhro, R., Freedman, J. E., Toolan, G., Loscalzo, J., and Valeri, C. R. (1999): O-raffinose cross-linking markedly reduces systemic and renal vasoconstrictor effects of unmodified human hemoglobin. J. Pharmacol. Exp. Ther. 288:1278-1287.
304. Maalej, N., Albrecht, R., Loscalzo, J., and Folts, J. D. (1999): The potent platelet inhibitory effects of S-nitrosated albumin coating of artificial surfaces. J. Am. Coll. Cardiol. 33:1408-1414.
305. Maytin, M., Leopold, J. A., and Loscalzo, J. (1999): Oxidant stress in the vasculature. Curr. Athero. Rep. 1:156-164.
306. Pigazzi, A., Heydrick, S., Folli, F., Benoit, S., Michelson, A., and Loscalzo, J. (1999): Nitric oxide inhibits thrombin-receptor-activating peptide-induced phosphoinositide 3 kinase activity in human platelets. J. Biol. Chem. 274:14368-14375.
307. Price, D. T. and Loscalzo, J. (1999): Cellular adhesion molecules and atherogenesis. Am. J. Med. 107:85-97.
308. Rudd, M. A., Trolliet, M., Hope, S., Scribner, A. M., Daumerie, G., Toolan, G., Cloutier, T., and Loscalzo, J. (1999): Salt-induced hypertension in Dahl salt-resistant and salt- sensitive rats with NOS II inhibition. Am. J. Physiol. 277:H732-H739.
309. Zai, A., Rudd, M. A., Scribner, A. W., and Loscalzo, J. (1999): Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide. J. Clin. Invest. 103:393-399.
310. Zhang, Y. and Loscalzo, J. (1999): S-nitroso-proteins. Curr. Protocols Toxicol. 10.3.1- 10.3.8.
311. Awtry, E. H. and Loscalzo, J. (2000): Aspirin. Circulation 101:1206-1218.
312. Battinelli, E. M. and Loscalzo, J. Nitric oxide and platelet-mediated hemostasis. In Nitric Oxide and the Cardiovascular System. J. Loscalzo and J. A. Vita, eds. Totowa, NJ: Humana Press, pp.123-138, 2000.
313. Battinelli, E. M. and Loscalzo, J. (2000): Nitric oxide induces apoptosis in megakaryocytic cell lines. Blood 95:3451-3459.
314. Eberhardt, R. T. and Loscalzo, J. Nitric oxide in atherosclerosis. In Nitric Oxide and the Cardiovascular System. J. Loscalzo and J. A. Vita, eds. Totowa, NJ: Humana Press, pp.273-295, 2000.
315. Folts, J. D. and Loscalzo, J. Coating arterial and blood-contacting surfaces with NO°- donating compounds. In Nitric Oxide and the Cardiovascular System. J. Loscalzo and J. A. Vita, eds. Totowa, NJ: Humana Press, pp.503-514, 2000.
316. Freedman, J. E. and Loscalzo, J. Thrombotic disorders and nitric oxide insufficiency. In Nitric Oxide and the Cardiovascular System. J. Loscalzo and J. A. Vita, eds. Totowa, NJ: Humana Press, pp.297-307, 2000.
317. Glassberg, J. and Loscalzo, J. Endothelial function in end-stage renal failure. In Cardiovascular Disease in End-stage Renal Failure. J. Loscalzo and G. M. London, eds. Oxford, UK: Oxford University Press, pp.117-155, 2000.
318. Leopold, J. A. and Loscalzo, J. (2000): Clinical importance of understanding vascular biology. Cardiol. Rev. 8:115-123.
319. Leopold, J. A. and Loscalzo, J. S -Nitrosothiols. In Nitric Oxide and the Cardiovascular System. J. Loscalzo and J. A. Vita, eds. Totowa, NJ: Humana Press, pp.411-429, 2000.
320. Loscalzo, J. The biological chemistry of nitric oxide. In Nitric Oxide and the Cardiovascular System. J. Loscalzo and J. A. Vita, eds. Totowa, NJ: Humana Press, pp.3- 10, 2000.
321. Loscalzo, J. (2000): Homocysteine and atherothrombotic vascular disease. J. Thromb. Thrombolysis 9:125-126.
322. Loscalzo, J., Freedman, J. E., Inbal, A., Keaney, J. F., Jr., Michelson, A. D., and Vita, J. A. (2000): Nitric oxide insufficiency and arterial thrombosis. Trans. Am. Clin. Climatol. Assoc. 111:158-163.
323. Loscalzo, J. (2000): What we know and don’t know about L-arginine and NO. Circulation 101:2126-2129.
324. Loscalzo, J. (2000): Vascular matrix and vein graft failure: is the message in the medium? Circulation 101:221-223.
325. Rudd, M. A., Trolliet, M., and Loscalzo, J. Nitric oxide and hypertension. In Nitric Oxide and the Cardiovascular System. J. Loscalzo and J. A. Vita, eds. Totowa, NJ: Humana Press, pp.227-246, 2000.
326. Yang, Y. and Loscalzo, J. (2000): Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxide. Circulation 101:2144-2148.
327. Eberhardt, R.T., and Loscalzo, J. Homocysteine and endothelial dysfunction. In Homocysteine and Vascular Disease. K. Robinson, ed. Dordrecht, the Netherlands:Kluwer Academic Publishers, pp.371-387, 2000.
328. Gocke, N., and Loscalzo, J. Endothelial dysfunction and and atherothrombosis. In Atlas of Atherosclerosis: Risk Factors and Treatment. P.W.F. Wilson, ed. Philadelphia, PA:Current Medicine, pp.21-40, 2000.
329. Loscalzo, J. The molecular basis of human disease. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp.3-12, 2000.
330. Awtry, E.H., and Loscalzo, J. Structure and function of the normal heart and blood vessels. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 21-29, 2000.
331. Awtry, E.H., and Loscalzo, J. Evaluation of the patient with cardiovascular disease. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 30-42, 2000.
332. Mendes, L.A., and Loscalzo, J. Diagnostic tests and procedures in the patient with cardiovascular disease. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 43-55, 2000.
333. Mendes, L.A., and Loscalzo, J. Heart failure and cardiomyopathy. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 56-62, 2000.
334. Mendes, L.A., and Loscalzo, J. Congenital heart disease. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 63-68, 2000.
335. Mendes, L.A., and Loscalzo, J. Acquired valvular heart disease. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 69-78, 2000.
336. Awtry, E.H., and Loscalzo, J. Coronary heart disease. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 79-99, 2000.
337. Awtry, E.H., and Loscalzo, J. Cardiac arrhythmias. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 100-126, 2000.
338. Mendes, L.A., and Loscalzo, J. Myocardial and pericardial disease. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 127-136, 2000.
339. Mendes, L.A., and Loscalzo, J. Other cardiac topics. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 137-144, 2000.
340. Awtry, E.H., and Loscalzo, J. Vascular diseases and hypertension. In Cecil Essentials of Medicine. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 145-163, 2000.
341. Eberhardt, R.T., Forgione, M.A., Cap, A., Leopold, J.A., Rudd, M.A., Trolliet, M.T., Heydrick, S., Stark, R., Klings, E.S., Moldovan, N.I., Yaghoubi, M., Goldschmidt- Clermont, P.J., Farber, H.W., Cohen, R.A., and Loscalzo, J. (2000): Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J. Clin. Invest. 106:483- 491.
342. Upchurch, G.E., Jr., and Loscalzo, J. Nitric oxide and vascular disease. In Current Therapy in Vascular Surgery. C.B. Ernst and J.C. Stanley, eds. St. Louis, MO:Mosby, pp.365-367, 2000.
343. Gurevitz, O., Skutelsky, E., Eldar, M., Tamarin, I., Shenkman, B., Eskaraev, R., Varon, D., Loscalzo, J., and Inbal, A. (2000): S-nitrosoderivative of a recombinant fragment of von Willebrand factor (S-nitroso-AR545C) inhibits thrombus formation in guinea pig carotid artery thrombosis model. Thromb. Hemostas. 84:91-916.
344. Leopold, J.A., and Loscalzo, J. (2000): Cyclic strain modulates resistance to oxidant stress by increasing glucose-6-phosphate dehydrogenase expression in vascular smooth muscle cells. Am. J. Physiol. 279:H2477-H2485.
345. Zhang, Y., Hammarberg, T., Radmark, O., Samuelsson, B., Ng, C.F., Funk, C.D., and Loscalzo, J. (2000): Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labeling: binding characteristics and amino acid sequences. Biochem. J. 351:697-707.
346. Forgione, M.A., Leopold, J.A., and Loscalzo, J. (2000): Roles of endothelial dysfunction in coronary artery disease. Curr. Op. Cardiol. 15:409-415.
347. Loscalzo, J. (2000): Endothelium, nitric oxide, and atherosclerosis: from basic mechanisms to clinical implications. Circulation 102:e51 (book rev.).
348. Forgione, M.A., and Loscalzo, J. (2000): Oxidant stress as a critical determinant of endothelial function. Drug News Perspect. 13:523-529
349. Halle, D.A., and Loscalzo, J. (2001): Lipid disorders: diagnosis, management, and controversy. In Textbook of Primary Care. J. Noble, ed. St. Louis, MO:Mosby, pp. 634- 653.
350. Upchurch, G.R., Jr., Goodman, D.G., Willoughby, S.R., Zhang, Y.Y., Welch, G.N., Freedman, J.E., Ye, S., Costello, C.E., and Loscalzo, J. (2001): Heparin reacts with and inactivates nitric oxide. J. Cardiovasc. Pharm. Therap. 6:163-173.
351. Loscalzo, J. (2001): The tangled web of heart failure–a complex network of surrogates and correlates. J. Cardiovasc. Electrophysiol. 12:301-302.
352. Loscalzo, J. (2001): Resolution of platelet-rich thrombi in essential thrombocythemia: mechanisms, risks, and benefits of antiplatelet therapy. Mayo Clin. Proc. 76:356-357.
353. Loscalzo, J. (2001): Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ. Res. 88:756-762.
354. Trolliet, M.R., Rudd, M.A., and Loscalzo, J. (2001): Oxidative stress and renal dysfunction in salt-sensitive hypertension. Kid. Bl. Press. Res. 24:116-123..
355. Valeri, C.R., Cassidy, G., Pivacek, L.E., Ragno, G., Lieberthal, W., Crowley, J.P., Khuri, S., and Loscalzo, J. (2001): Anemia-induced increase in bleeding time: implications for treatment of non-surgical blood loss. Transfusion 41:977-982.
356. Leopold, J.A., Cap, A., Scribner, A.W., Stanton, R.C., and Loscalzo, J. (2001): Glucose- 6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability. FASEB J. 15:1771-1773.
357. Loscalzo, J. (2001): Genetic clues to the cause of primary pulmonary hypertension. N. Engl. J. Med. 345:367-371.
358. Loscalzo, J. (2001): Inducible nitric oxide synthesis in the vasculature: molecular context defines physiologic response. Arterio. Thromb. Vasc. Biol. 21:1259-1260.
359. Loscalzo, J. (2001): An experiment of nature: genetic L-arginine deficiency and NO insufficiency. J. Clin. Invest. 108:663-664.
360. Gokce, N., Holbrook, M.A., Duffy, S.J., Demissie, S., Cupples, L.A., Keaney, J.F., Jr., Loscalzo, J., and Vita, J.A. (2001): Effects of black race and hypertension on brachial artery vasodilator function. Hypertension 38:1349-1354.
361. Loscalzo, J. (2001): Salt-sensitive hypertension and inducible nitric oxide synthase: form- function dichotomy of a coding region mutation, mutatis mutandis. Circ. Res. 89:292- 294.
362. Loscalzo, J. (2001): Folate and nitrate-induced endothelial dysfunction: a simple treatment for a complex pathobiology. Circulation 104:1086-1088.
363 Weiss, N., Zhang, Y.Y., Heydrick, S., Bierl, C., and Loscalzo, J. (2001): Overexpression of cellular gluatathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction. Proc. Nat’l. Acad. Sci.(USA) 98:12503-12508.
364. Battinelli, E.M., Willoughby, S.R., Foxall, T., Valeri, C.R., and Loscalzo, J. (2001): Induction of platelet formation from megakaryocytoid cells by nitric oxide. Proc. Nat’l. Acad. Sci.(USA) 98:14458-14463
365. Walker, J.L., Loscalzo, J., and Zhang, Y.-Y. (2002): 5-Lipoxygenase and human pulmonary artery endothelial cell proliferation. Am. J. Physiol. 282:H585-H593..
366. Weiss, N., Heydrick, S., Zhang, Y.-Y., Bierl, C., Cap, A., and Loscalzo, J. (2002): Cellular redox state and endothelial dysfunction in mild hyperhomocysteinemic cystathionine -synthase-deficient mice. Arterio. Thromb. Vasc. Biol. 2:34-41.
367. Zhang, Y.Y., Walker, J.L., Huang, A., Keaney, J.F., Jr., Clish, C.B., Serhan, C.H., and Loscalzo, J. (2002): Expression of 5-lipoxygenase in pulmonary artery endothelial cells. Biochem. J. 361:267-276.
368. Ignarro, L., Napoli, C.N., and Loscalzo, J. (2002): Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide. Circ. Res. 90:21-28.
369. Chaves, C., Voetsch, B., Loscalzo, J., Caplan, L., Chavail, R. (2002): Case report: Extensive cerebral venous thrombosis secondary to moderate hyperhomocyst(e)inemia and successfully treated with thrombolysis. Cerebrovasc. Dis. 13:214-216.
370. Willoughby, S., and Loscalzo, J. (2002): Vascular control of platelet function. In Platelets in Thrombotic and Non-thrombotic Disorders: Pathophysiology, Pharmacology, and Treatment. P. Gresele, C.P. Page, J. Vermylen, V. Fuster, eds. Cambridge:Cambridge University Press, pp. 432-455.
371. Freedman, J.E., and Loscalzo, J. (2001): Fibrinolytic and antithrombotic therapy of peripheral vascular, cerebrovascular, and intracardiac disorders. In Cardiovascular Therapeutics, 2nd Edition. E.M. Antman, W.S. Colucci, A.M. Gotto, , Jr., M.E. Josephson, J. Loscalzo, S.Oparil, J.J. Popma, Eds. Philadelphia:Saunders, pp.695-703.
372. Loscalzo, J. (2002): Homocysteine in Health and Disease (Book review). N. Engl. J. Med. 346:385.
373. Loscalzo, J. (2002): Perspective: homocysteine and dementias. N. Engl. J. Med. 346:466- 468.
374. Awtry, E.H., and Loscalzo, J. (2002): Aspirin. In Platelets, A.D. Michelson, Ed. San Diego:Academic Press, pp. 745-768.
375. Forgione, M.A., Weiss, N., Heydrick, S., Cap, A., Klings E.S., Bierl, C., Eberhardt, R.T., Farber, H.W., and Loscalzo, J. (2002): Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am. J. Physiol. 282:H1255-H1261.
376. Voetsch, B., Benke, K.S., Damasceno, B.P., Siqueira, L.H., and Loscalzo, J. (2002): the paraoxonase 192 Glu–>Arg polymorphism: an independent risk factor for arterial ischemic stroke among young adults. Stroke 33:1459-1464.
377. Russo, G., Leopold, J.A., and Loscalzo, J. (2002): Vasoactive substances: nitric oxide and endothelial dysfunction in atherosclerosis. Vasc. Pharmacol. 38:259-269.
378. Franciosa, J.A., Taylor, A.L., Cohn, J.N., Yancy, C.W., Ziesche, S., Olukotun, A., Ofili, E., Ferdinand, K., Loscalzo, J., and Worcel, M. (2002): African-American Heart Failure Trial (A-HeFT): rationale, design, and methodology. J. Cardiac Failure 8:128-135.
379. Sawyer, D.B. and Loscalzo, J. (2002): Myocardial hibernation: restorative or preterminal sleep? Circulation 105:1517-1519.
380. Jones, J.E., Mendes, L., Rudd, M.A., Russo, G., Loscalzo, J., and Zhang, Y.Y. (2002): Serial noninvasive assessment of progressive pulmonary hypertension in a rat model. Am. J. Physiol. 283:H364-H371.
381. Freedman, J.E., and Loscalzo, J. (2002): Platelet-monocyte aggregates: bridging thrombosis and inflammation. Circulation 105:2130-2132.
382. Kahn, D.F., Duffy, S.J., Tomasian, D., Holbrook, M., Rescorl, L, Russell, J., Gokce N., Loscalzo, J., and Vita, J.A. (2002): Effects of black race on forearm resistance vessel function. Hypertension 20:195-201.
383. Ruberg, F.L., Leopold, J.A., and Loscalzo, J. (2002): Atherothrombosis: plaque instability and thrombogenesis. Prog. Cardiovasc. Dis. 44:381-394.
384. Forgione, M.A., Cap, A., Liao, R., Moldovan, N.I., Eberhardt, R.T., Lim, C.C., Jones, J., Goldschmidt-Clermont, P.J., and Loscalzo, J. (2002): Heterozygous cellular glutathione peroxidase (GPx-1) deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation 106:1154-1158.
385. Napoli, C., Lerman, L.O., de Nigris, F., Loscalzo, J., and Ignarro, L.I. (2002): Glycoxidized low-density lipoprotein downregulates endothelial nitric oxide synthase in human coronary cells. J. Am. Coll. Cardiol. 40:1515-1522.
386. Vita, J.A., and Loscalzo, J. (2002): Shouldering the risk factor burden: infection, atherosclerosis, and the vascular endothelium. Circulation 106:164-166.
387. Tawakol, A., Forgione, M.A., Stuehlinger, M., Alpert, N.M., Cooke, J.P., Loscalzo, J., Fischman, A.J., Creager, M.A., and Gewirtz, H. (2002): Homocysteine impairs coronary microvascular dilator function in humans. J. Am. Coll. Cardiol. 40:1051-1058.
388. Roberts, R., Bonow, R.O., Loscalzo, J., Mosca, L. (2002): Report of the American Heart Association Task Force on Strategic Research Direction: Executive Summary. Circulation 106:2630-2632.
389. Loscalzo, J., Balaban, R., Becker, L.B., Ginsburg, G.S., Hachinski, V.C., Hall, J.E., Heistad, D.D., Leinwand, L.A., Lenfant, C.J., Marban, E., Olson, E.N., and Schwartz, S.M. (2002): Task Force on Strategic Research Direction: Basic Science Subgroup. Circulation 106:e149-3161.
390. Voetsch, B., and Loscalzo, J. (2002): Homocysteine MTHFR677CT polymorphism, and ischemic stroke risk. Journal Watch Neurology 4:90-91.
391. Weiss, N., Keller, C., Hoffman, U., and Loscalzo, J. (2002): Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vasc. Med. 7:227-239.
392. Loscalzo, J. (2002): Oxidative stress in endothelial cell dysfunction and thrombosis. Pathophysiol. Haemostas. Thromb. 32:359-360.
393. Willoughby, S.R., Holmes, A.S., and Loscalzo, J. (2002): Platelets and cardiovascular disease. Eur. J. Cardiovasc. Nurs. 1:273-288.
394. Eisenberg, M.S., , Rabbani, L. E., and Loscalzo, J. The relationship between thrombosis and atherosclerosis. In Thrombosis and Hemorrhage, 3rd Edition. J. Loscalzo and A. I. Schafer, eds. Philadelphai:Lippincott, Williams & Wilkins, pp.628-647, 2003.
395. Voetsch, B., Afshar-Kharghan, V., Loscalzo, J., and Schafer, A. Less common thrombotic and embolic disorders. In Thrombosis and Hemorrhage, 3rd Edition. J. Loscalzo and A. I. Schafer, eds. Philadelphai:Lippincott, Williams & Wilkins, pp.707-762, 2003.
396. Leopold, J.A., and Loscalzo, J. The pharmacology of thrombolytic agents. In Thrombosis and Hemorrhage, 3rd Edition. J. Loscalzo and A. I. Schafer, eds. Philadelphai:Lippincott, Williams & Wilkins, pp.949-977, 2003.
397. Freedman, J.E., and Loscalzo, J. New antithrombotic strategies. In Thrombosis and Hemorrhage, 3rd Edition. J. Loscalzo and A. I. Schafer, eds. Philadelphai:Lippincott, Williams & Wilkins, pp.978-995, 2003.
398. Loscalzo, J., and Schafer, A.I.. Overview of hemostasis and fibrinolysis. In New Therapeutic Agents in Thrombosis and Thrombolysis, 2nd Edition. A.A. Sasahara and J. Loscalzo, Eds., New York:Marcel Dekker, pp. 1-7, 2003.
399. Sharis, P.J., and Loscalzo, J. Thienopyridines: ticlopidine and clopidogrel. In New Therapeutic Agents in Thrombosis and Thrombolysis, 2nd Edition. A.A. Sasahara and J. Loscalzo, Eds., New York:Marcel Dekker, pp. 431-449, 2003.
400. Awtry, E., and Loscalzo, J. An overview of platelet inhibitor agents. In Handbook of Antiplatelet Therapy. M. Cohen, Ed., London:Martin Dunitz, pp.83-96, 2003.
401. Loscalzo, J. (2003): Adverse effects of supplemental L-arginine in atherosclerosis: consequences of a methylation stress in a complex catabolism? Arterio. Thromb. Vasc. Biol., 23:1-2.
402. Ruberg, F.L., and Loscalzo, J. (2003): Prothrombotic determinants of coronary atherothrombosis. Vasc. Med. 7:289-299.
403. Leopold, J.A., and Loscalzo, J. (2003): Organic nitrate tolerance and endothelial dysfunction: role of folate therapy. Minerva Cardioangio. 51:349-359.
404. Loscalzo, J. (2003): Functional polymorphisms in a candidate gene for atherothrombosis: unraveling the complex fabric of a polygenic phenotype. J. Am. Coll. Cardiol. 41:946 948.
405. Freedman, J.E., and Loscalzo, J. (2003): Nitric oxide and its relationship to thrombotic disorders. J. Thromb. Haemostas. 1:1183-1188.
406. Leopold, J.A., Zhang, Y.Y., Scribner, A.M., Stanton, R.C., and Loscalzo, J. (2003): Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide. Arterio. Thromb. Vasc. Biol. 23:411-417.
407. Nedeljkovic, Z.S., Gokce, N., and Loscalzo, J. (2003): Mechanisms of oxidative stress and vascular dysfunction. Postgrad. Med. J. 79:195-200.
408. Gocke, N., and Loscalzo, J. The endothelium in atherothrombosis. In Atlas of Atherosclerosis: Risk Factors and Treatment. P.W.F. Wilson, ed. Philadelphia, PA:Current Medicine, pp.21-40, 2003.
409. Forde, P., Scribner, A.M., Dial, R., Loscalzo, J., and Trolliet, M.R. (2003): Prevention of hypertension and renal dysfunction in Dahl rats by alpha-tocopherol. J. Cardiovasc. Pharm., 42:82-88.
410. Handy, D.E., and Loscalzo, J. (2003): Homocysteine and atherothrombosis:diagnosis and treatment. Curr. Athero. Rep., in press.
411. Walford, G., and Loscalzo, J. (2003): Nitric oxide and vascular biology. J. Thromb. Haemostas. 1:2112-2118.
412. Dardik, R., Solomon, A., Loscalzo, J., Eskaraev, R., Bialik, A., Goldberg, I., Schiby, G., and Inbal, A. (2003): Novel proangiogenic effect of factor XIII (FXIII) associated with suppression of thrombospondin (TSP-1) expression. Arterio. Thromb. Vasc. Biol. 23:1472-1477.
413. Loscalzo, J. (2003): Cardiovascular proteomics. Circulation 108:380-383.
414. Eberhardt, R.T., McMahon, L., Duffy, S.J., Steinberg, M.H., Perrine, S.P., Loscalzo, J.,Coffman, J.D., and Vita, J.A. (2003): Sickle cell disease is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels. Am. J. Hematol. 74:104-111.
415. Leopold, J.A., Walker, J., Scribner, A.M., Voetsch, B., Zhang, Y.Y., Loscalzo, A.J., Stanton, R.C., and Loscalzo, J. (2003): Glucose_6_phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. J. Biol. Chem. 278:32100- 32106.
416. Handy, D.E., and Loscalzo, J. (2003): Homocysteine and atherothrombosis: diagnosis and treatment. Curr. Athero. Rep. 5:276-283.
417. Leopold, J.A., and Loscalzo, J. Markers of a thrombotic state. In Acute Coronary Syndromes. P. Theroux, ed. Philadelphia, PA:Saunders, pp.197_203, 2003.
418. Loscalzo, J. S-nitrosothiols in cell signaling. In Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles. H.J. Forman, J. Fukuto, and M. Torres, eds. Dordrecht:Kluwer, pp. 155-166, 2003.
419. Manger, W.M., Simchon, S., Stier, C.T., Loscalzo, J., Jan, K.-M., Jan, R., and Haddy, F. (2003): Effects of varying dietary potassium chloride on NaCl-dependent hemodynamics in Rapp/Dahl rats. J. Hypertens. 21:2305-2313.
420. Loscalzo, J. (2003): Oxidant stress: a key determinant ofatherothrombosis. Biochem. Soc. Trans. 31:1059-1060.
421. Loscalzo, J. (2003): The evolution of the discipline of vascular biology: from systems physiology to molecular biology to molecular systems. Circ. Res. 93:583-585.
422. Scribner, A.W., Loscalzo, J., and Napoli, C. (2003): The effect of angiotensin converting enzyme inhibition on endothelial function and oxidant stress. Eur. J. Pharmacol. 482:95- 99.
423. Cohn, J.N., Loscalzo, J., and Franciosa, J.A. (2003): Introduction: nitric oxide--role in heart failure, pathophysiology and treatment. J. Card. Fail. 9:S197-S198.
424. Weiss, N., Heydrick, S.J., Postea, O., Keller, C., Keaney, J.F., Jr., and Loscalzo, J. (2003): Influence of hyperhomocysteinemia on the cellular redox state–impact on homocysteine- induced endothelial dysfunction. Clin. Chem. Lab. Med. 41:1455-1461.
425. Voetsch, B., and Loscalzo, J. Genetic determinants of atherothrombotic disease. In Recent Advances in Haematology.. V.P. Choudhry, R. Saxena, and H.P. Pati, eds. New Delhi:Jaypee Bros., pp. 275-287.
426. Awtry, E.H., and Loscalzo, J. Structure and function of the normal heart and blood vessels. In Cecil Essentials of Medicine, 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 23-31, 2003.
427. Awtry, E.H., and Loscalzo, J. Evaluation of the patient with cardiovascular disease. In Cecil Essentials of Medicine, 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 33-45, 2003.
428. Mendes, L.A., and Loscalzo, J. Diagnostic tests and procedures in the patient with cardiovascular disease. In Cecil Essentials of Medicine, 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 47-61, 2003.
429. Mendes, L.A., and Loscalzo, J. Heart failure and cardiomyopathy. In Cecil Essentials of Medicine., 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 63-70, 2003.
430. Mendes, L.A., and Loscalzo, J. Congenital heart disease. In Cecil Essentials of Medicine, 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 71-76, 20031.
431. Mendes, L.A., and Loscalzo, J. Acquired valvular heart disease. In Cecil Essentials of Medicine., 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 77-85, 2003.
432. Awtry, E.H., and Loscalzo, J. Coronary heart disease. In Cecil Essentials of Medicine., 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 87-108, 2003.
433. Awtry, E.H., and Loscalzo, J. Cardiac arrhythmias. In Cecil Essentials of Medicine, 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 109-135, 2003.
434. Mendes, L.A., and Loscalzo, J. Myocardial and pericardial disease. In Cecil Essentials of Medicine, 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 137-146, 2003.
435. Mendes, L.A., and Loscalzo, J. Other cardiac topics. In Cecil Essentials of Medicine., 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 147-154, 2003.
436. Awtry, E.H., and Loscalzo, J. Vascular diseases and hypertension. In Cecil Essentials of Medicine, 6th Edition. T.E. Andreoli, C.C.J. Carpenter, R.C. Griggs, and J. Loscalzo, eds. Philadelphia, PA:Saunders, pp. 155-173, 2003.
437. Jain, M., Brenner, D.A., Cui, L., Lim, C.C., Wang, B., Pimental, D.R.,Koh, S., Sawyer, D.B., Leopold, J.A., Handy, D., Loscalzo, J., Apstein, C.S., and Liao, R. (2003): Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ. Res. 93:e9-e16.
438. Loscalzo, J. (2004): Ozone-from environmental pollutant to atherogenic determinant. N. Engl. J. Med. 350:834-835.
439. Napoli, C.N., and Loscalzo, J. (2004): Nitric oxide and novel therapies for pulmonary hypertension. J. Cardiovasc. Pharm. Therap. 9:1-8.
440. Heydrick, S.J., Weiss, N., Cap, A.P., Thomas, S.R., Forgione, M.A., Eberhardt, R.T., Pimental, D.R., Loscalzo, J., and Keaney, J.F., Jr. (2004): L-Homocysteine and L- homocystine stereospecifically induce eNOS-dependent lipid peroxidation in endothelial cells. Free Rad. Biol. Med. 36:632-640.
441. Jain, M., Cui, L., Brenner, D.A., Wang, B., Handy, D.E., Leopold, J.A., Loscalzo, J., Apstein, C.S., and Liao, R. (2004): Increased myocardial dysfunction following ischemia- reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation 109:898- 903.
442. Voetsch, B., and Loscalzo, J. (2004): Genetic determinants of arterial thrombosis. Arterio. Thromb. Vasc. Biol. 24:216-229.
443. Voetsch, B., Bierl, C., Camargo, E.C.S., Deus-Silva, L., Ozelo, M.C., Massaro, A.R., Annichino-Bizzacchi, J., and Loscalzo, J. (2004): The combined effect of paraoxonase promoter and coding region polymorphisms on the risk of arterial ischemic stroke among young adults. Arch. Neuro. 61:351-356..
444. Loscalzo, J. (2004): Stems cells and regeneration of the cardiovascular system: facts, fictions, and uncertainties. Blood Cells Mol. Dis. 32:97-99.
445. Walford, G.A., Mossignac, R.-L., Scribner, A.W., Loscalzo, J., and Leopold, J.A. (2004): Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite- induced activation of mitochondrial-dependent and -independent pathways. J. Biol. Chem. 279:4425-4432.
446. Jones, J.E., Walker, J.L., Song, Y., Weiss, N., Cardoso, W.V., Tuder, R.M., Loscalzo, J., and Zhang, Y.Y. (2004): Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats. Am. J. Physiol 286:H1775-H1784.
447. Voetsch, B., and Loscalzo, J. (2004): Genetics of thrombophilia: impact on atherogenesis. Curr. Op. Lipid. 15:129-143.
448. Morel, N.M., Holland, J.M., van der Greef, J., Marple, E.W., Clish, C., Loscalzo, J., and Naylor, S. (2004): Introduction to systems biology: a new approach to understanding disease and treatment. Mayo Clin. Proc. 79:651-658.
449. Faxon, D.P., Creager, M.A., Smith, S.C., Jr., Pasternak, R.C., Olin, J.W., Bettmann, M.A., Criqui, M.H., Milani, R.V., Loscalzo, J., Kauman, J.A., Jones, D.W., and Pearce, W.H. (2004): Atherosclerotic Vascular Disease Conference: Executive Summary: atherosclerotic vascular disease conference proceedings for healthcare professionals from a special writing group of the American Heart Association. Circulation 109:2595-2604.
450. Faxon, D.P., Fuster, V., Libby, P., Beckman, J.A., Hiatt, W.R., Thompson, R.W., Topper, J.N., Annex, B.H., Rundback, J.H., Fabunmi, R.P., Robertson, R.M., and Loscalzo, J. (2004): Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology. Circulation 109:2617-2624.
451. Bierl, C., Voetsch-Forgione, B., Jin, R., Handy, D., and Loscalzo, J. (2004): Determinants of human plasma glutathione peroxidase (GPx-3) expression. J. Biol. Chem. 279:26839-26845.
452. Voetsch, B., Jin, R.C., and Loscalzo, J. (2004): Nitric oxide insufficiency and atherothrombosis. Histo. Cell Biol., in press.
453. Loscalzo, J. (2004): James T. Willerson, M.D., editor of circulation, 1993-2004: a note of appreciation. Circulation 110:2.
454. Loscalzo, J. (2004): The eagle’s view, or how to use this journal. Circulation 110:3.
455. Morris, S.M., and Loscalzo, J. (2004): Arginine metabolism: enzymology, nutrition, and clinical significance. Introduction to the symposium proceedings. J. Nutr. 134:2742S.
456. Loscalzo, J. (2004): L-Arginine and atherothrombosis. J. Nutr. 134:2798S-2800S.
457. Loscalzo, J. (2004): Arginine metabolism: enzymology, nutrition, and clinical significance. Session V: Therapeutic strategies and supplementation-discussion summary. J. Nutr. 135:2895S.
458. Loscalzo, J., and Morris, S.M. (2004): Symposium on arginine: conference summary. J. Nutr. 134:2896S-2897S.
459. Feelisch, M., and Loscalzo, J. (2004): Nitric oxide donors in cardiovascular disease. In Nitric Oxide Donors for Pharmaceutical and Biological Applications. P.G. Wang, T.B. Cai, and N. Taniguchi (Eds.). Wiley-VCH:Wenheim, pp. 285-298.
460. Farber, H., and Loscalzo, J. (2004): Pulmonary hypertension. N.Engl.J.Med. 351:1655- 1665
461. Jacobs, A.K., Smith, S.C., Jr., Popp, R.L., and Loscalzo, J. (2004): Ethics and professionalism: Can there be a consensus? An editorial comment on the report of the ACC/AHA Consensus Conference on Professionalism and Ethics. Circulation 110:2278- 2279.
462. Loscalzo, J (2005): Introduction and overview. In Molecular Mechanisms of Atherosclerosis. J. Loscalzo (Ed.). London:Taylor & Francis, p.1.
463. Ruberg, F.L., and Loscalzo, J. (2005): Inflammation and atherothrombosis. In Molecular Mechanisms of Atherosclerosis. J. Loscalzo (Ed.). London:Taylor & Francis, pp. 45-60.
464. Freedman, J.E., and Loscalzo, J. (2005): Thrombosis and atherosclerosis. In Molecular Mechanisms of Atherosclerosis. J. Loscalzo (Ed.). London:Taylor & Francis, pp. 85-94.
465. Handy, D.E., and Loscalzo, J. (2005): Homocysteine and atherogenesis. In Molecular Mechanisms of Atherosclerosis. J. Loscalzo (Ed.). London:Taylor & Francis, pp. 221-236.
466. Leopold, J.A., and Loscalzo, J. (2005): Rational contemporary molecular and cell-based therapies. In Molecular Mechanisms of Atherosclerosis. J. Loscalzo (Ed.). London:Taylor & Francis, pp. 261-282.
467. Loscalzo, J. (2005): Future directions. In Molecular Mechanisms of Atherosclerosis. J. Loscalzo (Ed.). London:Taylor & Francis, pp. 283-284.
468. Loscalzo, J., Bonow, R.O., and Jacobs, A.K. (2004): Coronary calcium screening and the American Heart Association news embargo. Circulation 110:3504-3505.
469. Handy, D.E., Scolaro, J., Chen, J., Huang, P., and Loscalzo, J. (2004): L-Arginine increases plasma homocysteine in apoE-/-iNOS-/- double knockout mice. Cell. Mol. Biol. 50:903-909.
470. Yang, Y., and Loscalzo, J. (2005): S-nitrosoprotein formation and localization in endothelial cells. Proc.Nat’l.Acad.Sci.(USA) 102:117-122.
471. Jin, R.C., Voetsch, B., and Loscalzo, J. (2005): Mechanisms of inhibition of platelet function. Microcirculation 12:247-258.
472. Loscalzo, J. (2005): Editor’s note. Circulation 111:382.
473. Dardik, R., Loscalzo, J., Eskaraev, R, and Inbal, A. (2005): Molecular mechanisms underlying the proangiogenic effect of factor XIII (FXIII). Arterio.Thromb.Vasc.Biol. 25:526-532.
474. Song, Y., Jones, J.E., Beppu, H., Keaney, J.F., Loscalzo, J., and Zhang, Y.-Y. (2005): Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 112:553-562.
475. Handy, D.E., Zhang, Y., and Loscalzo, J. (2005): Homocysteine downregulates glutathione peroxidase (GPx1) by decreasing translation. J.Biol.Chem. 280:15518-15525.
476. Matsui, R., Xu, S., Maitland, K., Hayes, A., Leopold, J.A., Handy, D.E., Loscalzo, J., and Cohen, R.A. (2005): Glucose-6-phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation 112:257-263.
477. Leopold, J., and Loscalzo, J. (2005): Oxidative enzymopathies and vascular disease. Arterio.Thromb.Vasc.Biol. 25:1332-1340.
478. Benjamin, I.J., Arnett, D.K., Loscalzo, J., and the American Heart Association Basic Science Writing Group (2005): Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group. Circulation 111:3120-e123.
479. Farber, H.W., and Loscalzo, J. (2005): Mechanism of disease: pulmonary hypertension. Disc.Med. 25:80-87.
480. Loscalzo, J., Voetsch, B., Liao, R., and Leopold, J. (2005): Genetic determinants of vascular oxidant stress and endothelial dysfunction. Cong.Heart Failure 11:73-79.
481. Zhang, Y., Handy, D.E., and Loscalzo, J. (2005): Adenosine-dependent induction of glutathione peroxidase 1 (GPx-1) in human primary endothelial cells and protection against oxidative stress. Circ.Res. 96:831-837.
482. Ruberg, R.L., and Loscalzo, J. (2005): Vascular thromboresistance and the genetics of thrombotic risk. In Clinical, Interventional, and Investigational Thrombocardiology. R.C. Becker and R.A. Harrington (Eds.), Boca Raton:Taylor & Francis, pp. 31-53.
483. Gokce, N., Carr, J., and Loscalzo, J. (2005): Vascular biology and pathobiology in acute coronary syndromes. In Clinical, Interventional, and Investigational Thrombocardiology. R.C. Becker and R.A. Harrington (Eds.), Boca Raton:Taylor & Francis, pp. 55-72.
484. Loscalzo, J. (2005): Editor’s note. Circulation 112:2.
485. Antman, E.M., DeMets, D., and Loscalzo, J. (2005): Cyclooxygenase inhibition and cardiovascular risk. Circulation 112:759-770.
486. Loscalzo, J. (2005): Homocysteine, oxidative stress, and atherothrombosis. In Proceedings of the 4th International Conference on Homocysteine Metabolism. B. Fowler (Ed.), pp. 69-74.
487. Napoli, C., and Loscalzo, J. (2005): New challenges for ACI-inhibitors in vascular diseases. Drug Design Revs., in press.
488. Robbins, I.M., Kawut, S.M., Yung, D., Reilly, M.P., Lloyd, W., Cunningham, G., Loscalzo, J., Kimmel, S.E., Christman, B.W., Barst, R.J. (2005): A randomized controlled trial of aspirin and clopidogrel in patients with idiopathic pulmonary arterial hypertension. Eur.Resp.J., in press.
489. Loscalzo, J. (2005): Clinical trials in cardiovascular medicine in an era of marginal benefit, bias, and hyperbole. Circulation 112:3026-3029.
490. Ruberg, F.L., Viereck, J., Phinikaridou, A., Qiao, Y., Loscalzo, J., and Hamilton, J.A. (2006): Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proteon magnetic resonance spectroscopy. J. Lipid Res. 47:310-317.
491. Dardik, R., Loscalzo, J., and Inbal, A. (2006): Factor XIII (FXIII) and angiogenesis. J.Thromb.Haemostas. 4:19-25.
492. Kamath, A.F., Chauhan, A.K., Kisucka, J., Dole, V.S., Loscalzo, J., Handy, D.E., and Wagner, D.D. (2006): Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood 107:5951-593.
493. Galasso, G., Schiekofer, S., Sato, K., Shibata, R., Handy, D.E., Ouchi, N., Leopold, J.A., Loscalzo, J., and Walsh, K. (2005): Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ.Res. 98:254-261.
494. Handy, D.E., Hang, G., Scolaro, J., Metes, N., Razaq, N., Yang, Y., and Loscalzo, J. (2005): Aminoglycosides decrease glutathione peroxidase-1 activity by interfering with selenocysteine incorporation. J.Biol.Chem. 281:3382-3388.
495. Dardik, R., Leor, J., Skutelsky, E., Castel, D., Holbova, R., Schiby, G., Shaish, A., Dickneite, G., Loscalzo, J., and Inbal, A. (2006): Evaluation of the pro-angiogenic effect of factor XIII in heterotopic mouse heart allografts and FXIII-deficient mice. Thromb. Haemostas. 95:546-550.
496. Matsui, R., Xu, S., Maitland, K.A., Mastroianni, R., Leopold, J.A., Handy, D.E., Loscalzo, J., and Cohen, R.A. (2006): Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide anion and atherosclerotic lesions in apolipoprotein E-/- mice. Arterio.Thromb.Vasc.Biol., in press.
497. Raiesdana, A., and Loscalzo, J. (2006): Pulmonary arterial hypertension. Ann.Med. 38:95-110.
498. Robbins, I.M., Kawut, S.M., Yung, D., Reilly, M.P., Lloyd, W., Cunningham, G., Loscalzo, J., Kimmel, S.E., Christman, B.W., and Barst, R.J. (2006): A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension. Eur.Resp.J. 27:578-584.
499. Loscalzo, J. (2006): Homocysteine trials—clear outcomes for complex reasons. N.Engl.J.Med. 354:1529-1632.
500. Handy, D.E., and Loscalzo, J. (2006): Nitric oxide and posttranslational modification of the vascular proteome. S-nitrosation of reactive thiols. Arterio.Thromb.Vasc.Biol. 26:1207-1214.
501. Loscalzo, J. (2006): Nitric oxide redux. Arterio.Thromb.Vasc.Biol. 26:696.
502. Ruberg, F.L., and Loscalzo, J. (2006): Normal mechanisms of hemostasis. In Vascular Medicine: A Companion to Braunwald’s Heart Disease. M.A. Creager, V.J. Dzau, and J. Loscalzo (Eds.), Philadelphia:Elsevier, pp. 61-69.
503. Freedman, J.E., and Loscalzo, J. (2006): Thrombosis. In Vascular Medicine: A Companion to Braunwald’s Heart Disease. M.A. Creager, V.J. Dzau, and J. Loscalzo (Eds.), Philadelphia:Elsevier, pp. 125-133.
504. Kane, L.B., and Loscalzo, J. (2006): Pulmonary arterial hypertension. In Vascular Medicine: A Companion to Braunwald’s Heart Disease. M.A. Creager, V.J. Dzau, and J. Loscalzo (Eds.), Philadelphia:Elsevier, pp. 795-821.
505. Klings, E.S., and Loscalzo, J. (2006): Seconary pulmonary hypertension. In Vascular Medicine: A Companion to Braunwald’s Heart Disease. M.A. Creager, V.J. Dzau, and J. Loscalzo (Eds.), Philadelphia:Elsevier, pp. 822-831.
506. Roberts, W.C., and Loscalzo, J. (2006): Joseph Loscalzo, M.D., Ph.D.: a conversation with the editor. Am.J.Cardiol. 97:1110-1122.
507. Loscalzo, J. (2006): The NIH budget and the future of biomedical research. N.Engl.J.Med. 354:1665-1667.
508. Sam, F., Halickman, I., Vita, J.A., Levitsky, Y., Cupples, L.A., Loscalzo, J., Allensworth-Davies, D. (2006): Clinical predictors of improved left ventricular systolic function in an urban cardiomyopathy program. Am.J.Cardiol. 98:1622-1626.
509. Maitland, K., Bridges, L., Davis, W.P., Loscalzo, J., and Pointer, M.A. (2006): Different effects of angiotensin receptor blockade on end-organ damage in salt-dependent and salt-independent hypertension. Circulation 114:905-911.
510. Maron, B., and Loscalzo, J. (2006): Homocysteine. Clin.Lab.Med. 26:591-609.
511. Johnson, R., Leopold, J., and Loscalzo, J. (2006): Vascular calcification: pathobiological mechanisms and clinical implications. Circ.Res. 99:1044-1059.
512. Maron, B.A., and Loscalzo, J. (2006): The role of platelets in fibrinolysis. In Platelets, 2nd Edition, A. Michelson (Ed.), Burlington:Academic Press, pp. 415-430.
513. Awtry, E.A., and Loscalzo, J. (2006): Aspirin. In Platelets, 2nd Edition, A. Michelson (Ed.), Burlington:Academic Press, pp. 1099-1125.
514. Dardik, R., Krapp, T., Rosenthal, E., Loscalzo, J., and Inbal, A. (2007): Effect of FXIII on monocyte and fibroblast function. Cell.Physiol.Biochem. 19:113-120.
515. Voetsch, B., Jin, R.C., Bierl, C., Benke, K.S., Kenet, G., Simioni, P., Ottaviano, F., Damasceno, B.P., Annichino-Bizacchi, J.M., Handy, D.E., and Loscalzo, J. (2007): Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke 38:41-49.
516. Leopold, J.A., Dam, A., Maron, B.A., Scribner, B.S., Liao, R., Handy, D.E., Stanton, R.C., Pitt, B., and Loscalzo, J. (2007): Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nature Med. 13:189-197.
517. Biolo, A., Chao, T., Duhaney, T.S., Kotlyar, E., Allensworth-Davies, D., Loscalzo, J., and Sam, F. (2007): Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict remodeling in African Americans versus non-African Americans with chronic systolic heart failure. Am.J.Cardiol. 100:285-290.
518. Loscalzo, J. (2007): Entrepreneurship in the medical academy: possibilities and challenges in commercialization of research discoveries. Circulation 115:1504-1507.
519. Yang, Y., and Loscalzo, J. (2007): S-nitrosated proteins: formation, metabolism, and function. In Radicals for Life: The Various Forms of Nitric Oxide. E. Van Faassen and A.F. Vanin (Eds.), Amsterdam:Elsevier, pp. 201-221.
520. Yang, Y., Song, Y., and Loscalzo, J. (2007): Regulation of the disulfide proteome by mitochondria in mammalian cells. Proc.Nat’l.Acad.Sci.(USA) 104:10813-10817.
521. Loscalzo, J., Kohane, I., and Barabasi, A.L. (2007): Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol.Syst.Biol. 3:124 (e-publication).
522. Letts, G., and Loscalzo, J. (2007): Targeting inflammation using novel NO donors. J.Am.Soc.Nephrol. 18:2863-2869.
523. Rajasekaran, N.S., Connell, P., Christians, E., Yan, L.-J., Taylor, R., Orosz, A., Zhang, X., Stevenson, T., Peshock, R., Leopold, J.A., Barry, W., Loscalzo, J., Odelberg, S., and Benjamin, I. (2007): Human alphaB-cystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell 130:427-439.
524. Maron, B.A., and Loscalzo, J. (2007): Should hyperhomocysteinemia be treated in patients with atherosclerotic disease? Curr.Athero.Rep. 9:375-383.
525. Sebastian, J.K., Voetsch, B., Stone, J.H., Romay-Penabad, Z., Lo, G.H., Allen, N.B., Davis, J.C., Jr., Hoffman, G.S., McCune, W.J., St. Clair, E.W., Specks, U., Spiera, R., Loscalzo, J., Pierangeli, S., and Merkel, P.A. for the Wegener’s Granulomatosis Etanercept Trial Research Group (2007): The frequency of anticardiolipin antibodies and genetic mutations with hypercoagulability among patients with Wegener’s granulomatosis with and without a history of a thrombotic event. J. Rheum. 34:2446-2450.
526. Lubos, E., Loscalzo, J., and Handy, D.E. (2007): Homocysteine and glutathione peroxidase-1. Antioxid.Redox Signal. 9:1-18.
527. Loscalzo, J. (2007): Association studies in an era of too much information. Clinical analysis of new biomarker and genetic data. Circulation 116:1866-1870.
528. Voetsch, B., Jin, R.D., Bierl, C., Deus-Silva, L., Camargo, E.C., Annichino-Bizacchi, J., and Loscalzo, J. (2008): The role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis. Stroke 39:303-307.
529. Chan, S., and Loscalzo, J. (2008): Pathogenic mechanisms of pulmonary arterial hypertension. J.Mol.Cell.Cardiol. 44:14-30.
530. Ottaviano, P., Handy, D.E., and Loscalzo, J. (2008): Redox regulation in the extracellular environment. Circ.J. 72:1-16.
531. Pitt, B., Loscalzo, J., Ycas, J., and Raichlen, J.S. (2008): Lipid levels after acute coronary syndromes. J.Am.Coll.Cardiol. 51:1440-1445.
532. Braunwald, E., and Loscalzo, J. (2008): Chapter 36: Edema. In Harrison’s Principles of Internal Medicine, 17th Edition. A. Fauci, E. Braunwald, D.L. Kasper, D.L. Longo, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 231-236.
533. Loscalzo, J (2008): Chapter 37: Palpitations. In Harrison’s Principles of Internal Medicine, 17th Edition. A. Fauci, E. Braunwald, D.L. Kasper, D.L. Longo, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 236-237.
534. Loscalzo, J., Braunwald, E., and Libby, P. (2008): Chapter 217: Basic biology of the cardiovascular system. In Harrison’s Principles of Internal Medicine, 17th Edition. A. Fauci, E. Braunwald, D.L. Kasper, D.L. Longo, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 1365-1375.
535. Antman, E., Selwyn, A.P., Braunwald, E., and Loscalzo, J. (2008): Chapter 237: Ischemic heart disease. In Harrison’s Principles of Internal Medicine, 17th Edition. A. Fauci, E. Braunwald, D.L. Kasper, D.L. Longo, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 1514-1527.
536. Creager, M.A., and Loscalzo, J. (2008): Chapter 242: Diseases of the aorta. In Harrison’s Principles of Internal Medicine, 17th Edition. A. Fauci, E. Braunwald, D.L. Kasper, D.L. Longo, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 1563-1568.
537. Creager, M.A., and Loscalzo, J. (2008): Chapter 243: Vascular diseases of the extremities. In Harrison’s Principles of Internal Medicine, 17th Edition. A. Fauci, E. Braunwald, D.L. Kasper, D.L. Longo, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, 1568-1575.
538. Loscalzo, J. (2008): A bold, new initiative for Circulation. A family of subspecialty journals. Circulation 117: 4-5.
539. Loscalzo, J., Tomaselli, G.F., Vaughan, D.E., and Walsh, R.A. (2008): ACCF 2008 Recommendations for Training in Adult Cardiovascular Medicine Core Cardiology Training (COCATS3) (Revision of the 2002 COCATS Training Statement) Task Force 7: Training in Cardiovascular Research. J.Am.Coll.Cardiol. 51:380-383.
540. Lubos, E., Handy, D.E., and Loscalzo, J. (2008): Role of oxidative stress and nitric oxide in atherothrombosis. Front.Biosci. 13:5323-5344.
541. Leopold, J.A., and Loscalzo, J. (2008): Oxidative mechanisms and atherothrombotic cardiovascular disease. Drug Disc.Today: Therap.Strat. 5:5-13.
542. Sung, A.D., Cheng, S., Moslehi, J., Scully, E.P., Prior, J.M., and Loscalzo, J. (2008): Hepatocellular carcinoma with intracavitary cardiac involvement: a case report and review of the literature. Am.J.Cardiol. 102:643-645.
543. HEART Group. A statement on ethics form the HEART Group. Circulation, in press.
544. Song, Y., Coleman, L., Shi, J., Beppu, H., Sato, K., Walsh, K., Loscalzo, J., and Zhang, Y.-Y. (2008): Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice. Am.J.Physiol. 295:H677-H690.
545. Blicharz, T.M., Rissin, D.M., Michaela, B., Hayman, R.B., DiCesare, C., Bhatia, J.S., Grand-Pierre, N., Siqueira, W.L., Helmerhorst, E.J., Loscalzo, J., Oppenheim, F.G., and Walt, D.R. (2008): Monitoring the effect of hemodialysis on salivary nitrite and uric acid in end-stage renal disease patients using colorimetric test strips: a proof of principle. Clin.Chem. 54:1473-1480.
546. Loscalzo, J. (2008): Membrane redox state and apoptosis: death by peroxide. Cell Metab. 8:182-183.
547. Loscalzo, J. (2008): Paraoxonase and coronary heart disease: language misleads, linkage misinforms, function clarifies., Circulation Cardiovascular Genetics 1:79-80.
548. Schnabel, R., Lubos, E., Messow, C.M., Sinning, C.R., Zeller, T., Wild, P.S., Peetz, D., Handy, D.E., Munzel, T., Loscalzo, J., Lackner, K.J., and Blankenberg, S. (2008): Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease: The SElenium Therapy in Coronary Artery disease Patients study. Am.Heart J. 1201:e1-e11.
549. Loscalzo, J. (2008): Buflomedil in peripheral arterial obstructive disease. (Update to Chapter 243). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001294.
550. Loscalzo, J. (2008): Rivaroxaban for prevention of venous thromboembolism. (Update to Chapter 256). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001318.
551. Loscalzo, J. (2008): Lack of effect of chronic anticholinergic therapy on the progression of chronic obstructive lung disease. (Update to Chapter 254). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001387.
552. Loscalzo, J. (2008): Benefit of catheter ablation in atrial fibrillation. (Update to Chapter 226). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001399.
553. Jahangir, E., Vita, J.A., Handy, D., Holbrook, M., Palmisano, J., Beal, R., Loscalzo, J., and Eberhardt, R.E. (2009): The effect of L-arginine and creatine on vascular function and homocysteine metabolism. Vasc.Med. 14:239-248
554. Maron, B.A., and Loscalzo, J. (2009): Treatment of hyperhomocysteinemia. Ann.Rev.Med. 60:39-64.
555. Loscalzo, J. (2009): Consequences of donating a kidney. (Update to Chapter 276). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001415.
556. Loscalzo, J. (2009): Percutaneous coronary intervention compared with coronary artery bypass grafting in severe coronary artery disease. (Update to Chapter 240). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001432.
557. Loscalzo, J. (2009): Cardiovascular prevention guidelines in practice. (Update to Chapter 218). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds). Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001449.
558. Loscalzo, J. (2009): Polypill use for cardiovascular risk factor reduction. (Update to Chapter 218). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds). Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001477.
559. Loscalzo, J. (2009): Antithrombotic therapy in chronic atrial fibrillation. (Update to Chapter 226). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds). Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001468.
560. Loscalzo, J. (2009): Bivalirudin in Primary Angioplasty for Acute Myocardial Infarction. (Update to Chapter 239). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001529.
561. Loscalzo, J. (2009): Advanced Heart Failure Treated with Left Ventricular Assist Device. (Update to Chapter 228). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001545.
562. Loscalzo, J. (2009): Lipoprotein(a) and risk of myocardial infarction. (Update to Chapter 237). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds). Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001493.
563. Loscalzo, J. (2009): Percutaneous coronary intervention compared with coronary artery bypass grafting in severe coronary artery disease. (Update to Chapter 240). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds). Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001432
564. Loscalzo, J. (2009): Roflumilast in moderate-to-severe chronic obstructive lung disease. (Update to Chapter 254). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds). Harrison's Principles of Internal Medicine, 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001519
565. Chamarthi, B., Morris, C.A., Kaiser, U.B., Katz, J.T., and Loscalzo, J. (2009): Stalking the diagnosis. N.Engl.J.Med., in press.
566. Malhotra, A., and Loscalzo, J. (2009): Sleep and cardiovascular disease: an overview. Prog.Cardiovasc.Dis. 51:279-284.
567. Raiesdana, A., and Loscalzo, J. (2009): Chapter 27: Pulmonary arterial hypertension. In Pharmacology and Therapeutics: Principles to Practice. S.A. Waldman and A. Terzic (Eds.), Philadelphia:Saunders, pp.405-415.
568. Bitton, A., Yialamas, M., Levy, B.D., Katz, J.T., Loscalzo, J. (2009): Clinical problem solving: A fragile balance. N.Engl.J.Med. 361:74-79.
569. Maron, B.A., Zhang, Y.-Y., Handy, D.E., Beuve, A., Tang, S.-S., Loscalzo, J., and Leopold, J.A. (2009): Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl-thiol oxidation in vascular smooth muscle cells. J.Biol.Chem. 284:7665-7672.
570. Ottaviano, F.G., Tang, S.-S., Handy, D.E., and Loscalzo, J. (2009): Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells. Mol.Cell.Biochem. 327:111-126.
571. Qin, W. Hu, W., Song, W., Blair, P., W, G., Hu, X., Song, Y., Bauer, S., Feelisch, M., Leopold, J.A., Loscalzo, J., and Halperin, J. (2009): Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am.J.Hematol. 84:221-227.
572. Handy, D.E., Lubos, E., Yang, Y., Galbraith, J.D., Kelly, N., Zhang, Y.-Y., Leopold, J.A., and Loscalzo, J. (2009): Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses. J.Biol.Chem. 284:11913-11921.
573. Loscalzo, J. (2009): Pilot trials in clinical research: of what value are they? Circulation 119:1694-1696.
574. Joseph, J., Handy, D.E., and Loscalzo, J. (2009): Quo vadis: whither homocysteine research? Cardiovasc.Toxicol., e-pub.
575. Freedman, J.E., Blair, P., and Loscalzo, J. (2009): Chapter 2: Overview of platelet-dependent thrombosis. In New Therapeutic Agents in Thrombosis and Thrombolysis, 3rd Edition. J.E. Freedman, J. Loscalzo (Eds.), New York:Informa Healthcare, pp.9-18.
576. Freedman, J.D., and Loscalzo, J. (2009): Chapter 38: Epilogue: the evolution of therapeutic management of thrombotic and cardiovascular disease. In New Therapeutic Agents in Thrombosis and Thrombolysis, 3rd Edition. J.E. Freedman, J. Loscalzo (Eds.), New York:Informa Healthcare, pp.667-670.
577. Xu, Y., Zhang, Z., Stillman, I., Osborne, B.W., Leopold, J.A., Handy, D.E., Loscalzo, J., and Stanton, R.C. (2009): Glucose-6-phosphate dehydrogenase deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J. 24:609-616.
578. McMahon, T., Solomon, C.G., Ross, J.J., Loscalzo, J., and Campion, E.W. (2009): Interactive medical cases—a new Journal feature. N.Engl.J.Med. 361:1112-1113.
579. Loscalzo, J. (2009): Homocysteine-mediated thrombosis and angiostasis in vascular pathology. J.Clin.Invest. 119:3203-3205.
580. Leopold, J.A., and Loscalzo, J. (2009): Oxidative risk for atherothrombotic cardiovascular disease. Free Rad.Biol.Med. 47:1673-1706.
581. Chan, S.Y., Zhang, Y.-Y., Hemann, C., Mahoney, C.E., Zweier, J.L., and Loscalzo, J. (2009): MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 10:273-284.
582. Lim, C.C., Bryan, N.S., Jain, M., Cui, L., Sawyer, D.B., Handy D.E., Loscalzo, J., Feelisch, M., and Liao, R. (2009): Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am.J.Physiol. 297:H2144-H2153.
583. Wolpin, B.M., Weller, P.F., Katz, J.T., Levy, B.D., and Loscalzo, J. (2009): Clinical problem solving: The writing on the wall. N.Engl.J.Med. 361:1387-1392.
584. Lubos, E., Sinning, C.R., Schnabel, R.B., Wild, P.S., Zeller, T., Ruprecht, H.J., Bickel, C., Lackner, K.J., Peetz, D., Loscalzo, J., Muenzel, T., and Blankenberg, S. (2009): Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene Study. Atherosclerosis 209:271-277.
585. Zhang, Z., Liew, C.W., Handy, D.E., Zhang, Y., Leopold, J.A., Hu, J., Kulkarni, R., Loscalzo, J., and Stanton, R.C. (2009): High glucose inhibits glucose-6-phosphate dehydrogenase leading to increased oxidative stress and beta cell apoptosis. FASEB J. 24:1497-1501.
586. Chan, S.Y., and Loscalzo, J. (2009): Pulmonary vascular disease related to hemodynamic stress in the pulmonary circulation. Comp. Physiol., in press.
587. Cuker, A., Connors, J.M., Katz, J.T., Levy, B.D., and Loscalzo, J. (2009): Clinical problem solving: A bloody mystery. N. Engl.J. Med. 361:1887-1894.
588. Levison, J.H., Barbieri, R.L., Katz, J.T., and Loscalzo, J. (2010): Clinical problem solving: Hard to conceive. N.Engl.J.Med. 363:965-970.
589. Miller, A.L., Falk, R.H., Levy, B.D., and Loscalzo, J. (2010): Clinical problem solving: A heavy heart. N.Engl.J.Med. 363:1464-1469.
590. Daumerie, G., Bridges, L., Maitland, K., Toolan, G., Yancey, S., Davis, W., Huang, P., Loscalzo, J., and Pointer, M.A. (2010): The effect of salt on renal damage in NOS deficient mice. Hypertension Res. 33:170-176.
591. Loscalzo, J. (2010): Antioxidant enzyme deficiencies and vascular disease. Expert Rev. Endocrinol. Metab. 5:15-18.
592. Chan, S.Y., and Loscalzo, J. (2010): MiroRNA-210: A unique and peliotropic hypoxamir. Cell Cycle 9:1072-1083.
593. Johnson, J.A., Everett, B.M., Katz, J.T., and Loscalzo, J. (2010): Clinical problem solving: Painful purple toes. N. Engl. J. Med. 362:67-73.
594. McMahon, G.T., Katz, J.T., Thorndike, M.E., Levy, B.D., and Loscalzo, J. (2010): Evaluation of a redesign initiative in an internal medicine residency. N. Engl. J. Med. 362:1304-1311.
595. Lubos, E., Mahoney, C.E., Leopold, J.A., Zhang, Y.-Y., Loscalzo, J., and Handy, D.E. (2010): Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression. FASEB J., in press.
596. Chamarthi, B., Morris, C.A., Kaiser, U.B., Katz, J.T., and Loscalzo, J. (2010): Clinical problem solving: Stalking the diagnosis. N. Engl. J. Med. 362:834-839.
597. Britton, K.A., Stevenson, W.G., Katz, J.T., and Loscalzo, J. (2010): Clinical problem solving: The beat goes on. N. Engl. J. Med. 362:1721-1726.
598. Berzin, T.J., Greenberger, N., Levy, B.D., and Loscalzo, J. (2010: Clinical problem solving: Worth a second look. N. Engl. J. Med., in press.
599. Musunuru, K., and Loscalzo, J. (2010): How I started my career in cardiology. AHA Connections 8:20-21.
600. Grad, Y., Seifter, J.L., Levy, B.D., and Loscalzo, J. (2010): Clinical problem solving: Bitter pills. N. Engl. J. Med. 363:1847-1951.
601. Hu, W., Jin, R., Zhang, J., You, T., Peng, Z., Ge, X., Bronson, R.T., Halperin, J.A., Loscalzo, J., and Qin, X. (2010): The critical roles of platelet activation and reduced nitric oxide bioavaibility in fatal pulmonary arterial hypertension in a murine hemolysis model. Blood 116:1613-1622.
602. Zeiler, T., Wild, P., Szymczak, S., Rotival, M., Schillert, A., Castagne, R., Maouche, S., Germain, M., Lackner, K., Rossmann, H., Eleftheriadis, M., Sinning, C.R., Schnabel, R.B., Lubos, E., Mennerich, D., Rust, W., Perret, C., Proust, C., Nicaud, V., Loscalzo, J., Hubner, N., Tregouet, D., Munzel, T., Ziegler, A., Tiret, L., Blankenberg, S., and Cambien, R. (2010): Genetics and beyond—the transcriptome of human monocytes and disease susceptibility. PLoS One 5:e10693.
603. Antman, E., Pfeffer, M., Stevenson, W., and Loscalzo, J. (2010): New section in Circulation: implications of contemporary clinical trials. Circulation 121:2446.
604. Zhang, Y.Y., Lauten, E., VerBerkmoes, J., Choi, J., Jin, R., Edwards, D.A., and Loscalzo, J. (2010): Nanoglycan complex-formulation extends VEGF retention time in the lung. iomacromolecules 11:1862-1872.
605. Liu, A.Y., Lowe, R.C., Levy, B.D., Katz, J.T., and Loscalzo, J. (2010): Clinical problem solving: A rash hypothesis. N. Engl. J. Med. 363:73-78.
606. Jin, R., and Loscalzo, J. (2010): Vascular nitric oxide: formation and function. J. Blood Med. 1:147-162.
607. Erzurum, S., Rounds, S.I., Stevens, T., Aldred, M., Aliotta, J., Archer, S.L., Asosingh, K., Balaban, R., Bauer, N., Bhattacharya, J., Bogaard, H., Choudhary, G., Dorn, G.W., Dweik, R., Fagan, K., Fallon, M., Finkel, T., Geraci, M., Gladwin, M.T., Hassoun, P.M., Humbert, M., Kaminski, N., Kawut, S.K., Loscalzo, J., McDonald, D., McMurtry, I.F., Newman, J., Nicolls, M., Rabinovitch, M., Shizuru, J., Oka, M., Polgar, P., Rodman, D., Schumacker, P., Stenmark, K., Tuder, R., Voelkel, N., Sullivan, E., Weinshilboum, R., Yoder, M.C., Zhao, Y., Gail, D., Moore, T.M. (2010): Strategic plan for lung vascular research: an NHLBI-ORDR workshop report. Am. J. Crit. Care Med., e-published.
608. Michas, G., Liberman, M., Becker, K.C., Handy, D.E., Loscalzo, J., and Leopold, J.A. (2010): Reciprocal regulation of 11beta-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro. Mol. Cell. Biochem. 346:69-79.
609. Loscalzo, J. (2010): The cellular response to hypoxia: tuning the system with microRNAs. J. Clin. Invest. 120:3815-3817.
610. Beckman, J.A., and Loscalzo, J. (2010): Circulation cardiovascular case series. Circulation 122:1661.
611. Lubos, E., Loscalzo, J., and Handy D.E. (2010): Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antiox. & Redox Signal., in press.
612. Loscalzo, J. (2010): Catheter Ablation of Stable Ventricular Tachycardia (Update to Chapter 226). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001571.
613. Loscalzo, J., Baron, R.M. (2010): Cystic Fibrosis Pulmonary Guidelines: Treatment of Pulmonary Exacerbations. (Update to Chapter 253). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001609.
614. Loscalzo, J., Miller, A.L. (2010): Use of Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms. (Update to Chapter 227). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition:
http://www.accessmedicine.com/updatesContent.aspx?aid=1001690.
615. Loscalzo, J., Baron, R.M. (2010): VX-770 in Patients with Cystic Fibrosis and the G551D-CFTR Mutation. (Update to Chapter 253). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition:
http://www.accessmedicine.com/updatesContent.aspx?aid=1001689.
616. Loscalzo, J., Baron, R.M. (2010): Tiotropium Step-Up Therapy for Adults with Uncontrolled Asthma (Update to Chapter 248). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001679.
617. Loscalzo, J., Miller, A.L. (2010): Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery. (Update to Chapter 230). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001678.
618. Loscalzo, J., Miller, A.L. (2010): Risk of Bleeding with Single, Dual, or Triple Therapy with Warfarin, Aspirin, and Clopidogrel. (Update to Chapter 226). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001671.
619. Loscalzo, J., Baron, R.M. (2010): Antibiotic Therapy and Treatment Failure in Patients Hospitalized for Acute Exacerbations of Chronic Obstructive Pulmonary Disease" (Update to Chapter 254). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition http://www.accessmedicine.com/updatesContent.aspx?aid=1001666.
620. Loscalzo, J., Miller, A.L. (2010): Predictors of Survival in Patients with Pulmonary Arterial Hypertension. (Update to Chapter 244). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition:
http://www.accessmedicine.com/updatesContent.aspx?aid=1001659.
621. Loscalzo, J., Miller, A.L. (2010): Cardiac Function in Survivors of Cancer. (Update to Chapter 231). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001658.
622. Loscalzo, J., Baron, R.M. (2010): Extended Valganciclovir Prophylaxis to Prevent Cytomegalovirus after Lung Transplantation. (Update to Chapter 260). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001649.
623. Loscalzo, J., Miller, A.L. (2010): CYP Genetic Variants, Clopidogrel, and Platelet Function. (Update to Chapter 237). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001648.
624. Loscalzo, J., Baron, R.M. (2010): Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma: A Multicenter, Randomized, Double-Blind, Sham-Controlled Clinical Trial. (Update to Chapter 248). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001631.
625. Loscalzo, J., Miller, A.L. (2010): Revascularization versus Medical Therapy for Renal Artery Stenosis" (Update to Chapter 241). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001630.
626. Handy, D.E., Castro, R., and Loscalzo, J. (2011): Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation 125:2145-2156.
627. Miller, A.L., Schissel, S., Levy, B.D., and Loscalzo, J. (2011): Clinical problem solving: A crazy cause of dyspnea. N. Engl. J. Med. 364:72-77.
628. Vaidya, A., Kaiser, U.B., Levy, B.D., and Loscalzo, J. (2011): Clinical problem solving: Lying Low. N. Engl. J. Med. 364:871-875.
629. Barabasi, A.-L., Gulbahce, N., and Loscalzo, J. (2011); Network medicine: a network-based approach to human disease. Nature Revs. Genet. 12:56-68.
630. Loscalzo, J. (2011): Systems biology and personalized medicine: a network approach to human disease. Proc. Am. Thorac. Soc. 364:196-198.
631. Loscalzo, J., and Barabasi, A.-L. (2011): Systems biology and the future of medicine. WIREs: Syst.Biol. & Med., in press.
632. Labunskyy, V.M., Lee, B.C., Handy, D.E., Loscalzo, J., Hatfield, D.L., and Gladyshev, V.N. (2011): Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antiox. & Redox Signal., in press.
633. Arnett, D.K., and Loscalzo, J. (2011): Inaccurate information in Capitol Health Call article. J.Am.Med.Assoc. 305:256-257.
634. Szent-Gyorgyi, L., Coblyn, J., Turchin, A., Loscalzo, J., and Kachalia, A. (2011): Building a department quality program: a patient-based and provider-led approach. Acad. Med. 86:314-319.
635. Loscalzo, J. (2011): Can scientific quality be quantified? Circulation 123:947-950.
636. Fisher, M., and Loscalzo, J. (2011): The perils of combination antithrombotic therapy and potential resolutions. Circulation 123:232-235.’
637. Gavin, M.C., Morse, D., Partridge, A.H., Levy, B.D., and Loscalzo, J. (2011): Clinical problem solving: Clear and present danger. N. Engl. J. Med., in press.
638. Rogal, S.S., Ukomadu, C., Levy, B.D., and Loscalzo, J. (2011): Clinical problem solving: A sweet source of abdominal pain. N. Engl. J. Med. 364:1762-1767.
639. Loscalzo, J., Baron, R.M. (2011): Lung Volumes and Emphysema in Smokers Who Have Interstitial Lung Abnormalities. (Update to Chapter 254). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001758.
640. Loscalzo, J., Baron, R.M. (2011): Prevention of COPD Exacerbations: Tiotropium versus Salmeterol. (Update to Chapter 254). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001754.
641. Loscalzo, J., Miller, A.L. (2011): CRP Elevation and Time Course of Normalization in Acute Pericarditis. (Update to Chapter 232). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001753.
642. Loscalzo, J., Miller, A.L. (2011): Relationship between Heart Rate Response during Exercise and Pregnancy Outcome in Women with Congenital Heart Disease. (Update to Chapter 229). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001744.
643. Loscalzo. J., Choi M.E. (2011): Molecular Architecture of the Goodpasture Autoantigen in Anti-GBM Nephritis. (Update to Chapter 277). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition:
http://www.accessmedicine.com/updatesContent.aspx?aid=1001743.
644. Loscalzo, J., Baron, R.M. (2011): Worldwide Burden of Disease from Exposure to Second-Hand Smoke. (Update to Chapters 85, 218, 248). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition:
http://www.accessmedicine.com/updatesContent.aspx?aid=1001738.
645. Loscalzo, J., Miller, A.L. (2011): Renal Sympathetic Denervation in Patients with Treatment-Resistant Hypertension. (Update to Chapter 241). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition:
http://www.accessmedicine.com/updatesContent.aspx?aid=1001719.
646. Loscalzo, J., Miller, A.L. (2011): Celiprolol for Prevention of Cardiovascular Events in Vascular Ehlers-Danlos Syndrome. (Update to Chapters 242, 357). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition: http://www.accessmedicine.com/updatesContent.aspx?aid=1001718.
647. Loscalzo, J., Baron, R.M. (2011): A Lung Protective Strategy for Organ Donors. (Update to Chapter 260). A.S. Fauci, E. Braunwald, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson, and J. Loscalzo (Eds.) Harrison’s Principles of Internal Medicine 17th Edition:
http://www.accessmedicine.com/updatesContent.aspx?aid=1001706.
648. Kajstura, J., Rota, M., Hall, S.R., Hosoda, T., D’Amario, D., Sanada, F., Zheng, H., Ogorek, B., Rondon-Clavo, C., Ferreira-Martins, J., Matsuda, A., Arranto, C., Goichberg, P., Giordano, G., Haley, K.J., Bardelli, S., Rayatzadeh, H., Liu, X., Quaini, F., Liao, R., Leri, A., Perrella, M.A., Loscalzo, J., and Anversa, P. (2011): Human lung stem cells. N. Engl. J. Med. 364:1795-1806.
649. Jin, R., Mahoney, C.E., Coleman, L., Ottaviano, F, Croce, K., Leopold, J.A., Zhang, Y-Y., Tang, S-S., Handy, D.E., and Loscalzo, J. (2011): Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. Circulation 123:1963-1973.
650. Horwitz, R.I., Kassirer, J.P., Holcombe, E.S., Humphrey, H.J., Verghese, A., Croft, C., Kwok, M., and Loscalzo, J. (2011): Internal medicine residency redesign: proposal of the internal medicine working group. Am. J. Med., in press.
651. Barroso, M., Rocha, M.S., Esse, R., Gomes, A., Teerlink, T., Jakobs, C., Blom, H.J., Loscalzo, J., Rivera, I., Tavares de Almeida, I., and Castro, R. (2011): Cellular hypomethylation is associated with impaired nitric oxide production by human endothelial cells. Amino Acids, in press.
652. Zhang, J, Handy, D.E., Wang, Y., Bouchard, G., Selhub, J., Loscalzo, J., and Carey, M.C. (2011): Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice. Hepatology, in press.
653. Chan, S., and Loscalzo, J. (2011): Endothelial regulation of pulmonary vascular tone. In Textbook of Pulmonary Vascular Disease. J. X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S.
Rich, S.L. Archer, and J.B. West (Eds.). New York:Springer, pp. 167-195.
654. Loscalzo, J. (2012): Chapter 35: Hypoxia and cyanosis. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 287-290.
655. Braunwald, E., and Loscalzo, J. (2012): Chapter 36: Edema. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 290-295.
656. Loscalzo, J. (2012): Chapter 37: Palpitations. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 295-296.
657. Loscalzo, J. (2012): Chapter e19: Systems biology in health and disease. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, e19-1-e19-7.
658. Freedman, J.E., and Loscalzo, J. (2012): Chapter 117: Arterial and venous thrombosis. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 983-988.
659. Loscalzo, J., Libby, P., and Epstein, J. (2012): Chapter 224: Basic biology of the cardiovascular system. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 1798-1811.
660. Loscalzo, J. (2012): Chapter 226: Approach to the patient with possible cardiovascular disease. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 1817-1820.
661. O’Gara, P.T., and Loscalzo, J. (2012): Chapter 227: Physical examination of the cardiovascular system. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 1821-1830.
662. O’Gara, P.T., and Loscalzo, J. (2012): Chapter 237: Valvular heart disease. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 1929-1950.
663. Stevenson, L.W., and Loscalzo, J. (2012): Chapter 238: Cardiomyopathy and myocarditis. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 1951-1970.
664. Antman, E., Selwyn, A.P., and Loscalzo, J. (2012): Chapter 243: Ischemic heart disease. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 1998-2015.
665. Antman, E., and Loscalzo, J. (2012): Chapter 245: ST-Segment elevation myocardial infarction. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 2021-2035.
666. Creager, M.A., and Loscalzo, J. (2012): Chapter 248: Diseases of the aorta. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 2060-2066.
667. Creager, M.A., and Loscalzo, J. (2012): Chapter 249: Vascular diseases of the extremities. In Harrison’s Principles of Internal Medicine, 18th Edition. D.L. Longo, A. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, and J. Loscalzo (Eds.), New York:McGraw-Hill, pp. 2066-2076.
668. Lubos, E., Kelly, N.J., Oldebeken, S.R., Leopold, J.A., Zhang, Y.-Y., Loscalzo, J., and Handy, D.E. (2011): Glutathione peroxidase-1 deficiency augments pro-inflammatory cytokine-induced redox signaling and human endothelial cell activation. J. Biol. Chem., in press.
669. Malinouski, M., Kehr, S., Finney, L., Vogt, S., Carlson, B.A., Seravalli, J., Jin, R., Handy, D.E., Park, T.J., Loscalzo, J., Hatfield, D.L., and Gladyshev, V.N. (2011): High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. Antiox. Redox Signal., in press.
670. Horwitz R.I., Kassirer, J.P., Holmboe, E.S., Humphrey, H.J., Verghese, A., Croft, C., Kwok, M., and Loscalzo, J. (2011): Internal medicine residency redesign: proposal of the internal medicine working group. Am. J. Med. 124:806-812.
671. Liberman, M., Johnson, R.C., Handy, D.E., Loscalzo, J., and Leopold, J.A. (2011): Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification. Biochem. Biophys. Res. Comm., in press.
672. Anversa, P., Kajstura, J., Leri, A., and Loscalzo, J. (2011): Tissue-specific adult stem cells in the lung. Nature Med. 17:1038-1039.
673. Zhao, Y., Jin, J., Hu, Z., Zhou, H.-M., Yi, J., Xu, L., Wang, X., Yang, Y., and Loscalzo, J. (2011): Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metab. 14:555-566.
674. Lee, A.I., Koo, S., Vaidya, A., Katz, J.T., and Loscalzo, J. (2011): Clinical problem-solving: A bird’s eye view of fever. New Engl. J Med. 365:1727-1732.
675. Handy, D.E., and Loscalzo, J. (2011): Redox regulation of mitochondrial function. Antiox. Redox Signal., in press.
676. Pointer, M.A., Daumerie, G., Bridges, L., Yancey, S., Howard, K., Davis, W., Huang, P., and Loscalzo, J. (2011): Physiological stress increases renal injury in eNOS-knockout mice. Hyperten. Res., in press.
