Funding Sources

Active

United States Department of Defense - Biomedical Translational Initiative
Transplantation of allograft face or facial subunit for treatment of severe facial deformity.
The major goal is to study the procedures, surgical technique, and the outcomes of facial composite tissue transplantation.

United States Department of Defense - Armed Forces Institute of Regenerative Medicine 
Portable perfusion system to increase preservation time of isolated limbs for replantation or allotransplantation.
The major goal is to develop a novel device that can extend allowable limb ischemia time by a factor of 2 to 3 from its current value.

Congressionally Directed Medical Research Programs - Defense Medical Research and Development Program Clinical Trial Award - Regenerative Medicine, Pain, Sensory System
A novel protocol for upper extremity restoration by transplantation with intent for tolerance induction
The major goal is to provide restoration of upper extremities using a novel protocol for tolerance induction in collaboration with investigators at the Massachusetts General Hospital.

United States Department of Defense - Armed Forces Institute of Regenerative Medicine II
Biomarker-Guided Withdrawal of Immunosuppressive Therapy in Recipients of Composite Tissue Allografts through the Generation of Peripheral Immune Tolerance
The major goal is to develop peripheral immune tolerance in a cohort of composite tissue allograft recipients using a novel tolerogenic protocol developed in collaboration with investigators at the Beth Israel Deaconess Medical Center.

Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program 2013
Branched nerve allografts to improve outcomes in facial composite tissue transplantation
The major goal of this study is to support the commercialization of a decellularized branched nerve allograft to improve functional outcomes in composite tissue transplantation and the correction of branched nerve defects.

Congressionally Directed Medical Research Programs - Clinical and Rehabilitative Medicine Research Program/Joint Program Committee - Regenerative Medicine Clinical Trial Award 
Novel Strategies to improve immunomodulation and non-invasive clinical monitoring in VCA
The major goal of this study is  enabling functional and aesthetic restoration to patients with severe, unreconstructable vascularized composite tissue defects by safe VCA protocols with minimal side effects.

Brigham and Women's Hospital Biomedical Research Institute
Center for Organ Preservation and Resurrection
The goal of this award is to develop a center for organ-specific preservation guided by markers of tissue function.

Stepping Strong Innovator Award
From Battlefield to Bedside: A Portable Device for Rescuing Limbs
The goal of this project is to develop a portable device for preservation of isolated limbs and other VCAs.

 

Completed:

Greenwall Foundation - Bioethics Award

Virtual tool to address facial appearance transfer in face transplantation.
The major goal is to determine the degree of resemblance between donors and recipients of three-dimensional virtual face transplants.

National Institutes of Health - R21 Award
Virtual tool to address facial appearance transfer in face transplantation.
The major goals are to determine whether three-dimensional virtual face transplant recipients are found to resemble their donors by a group of non-trained reviewers and the degree to which cephalometric measures influence the aesthetic outcomes of virtual facial transplantation.

Biomedical Research Institute at Brigham and Women's Hospital - Translatable Technologies Innovation Grant
Novel Approach to Attenuation of Ischemia-Reperfusion Injury in Limb Allografts
The major goal is to evaluate the therapeutic potential of two highly novel products – a portable isolated limb perfusion device, and an IgM antibody-binding peptide in attenuating ischemia/reperfusion injury in vascularized composite tissues

Greenwall Foundation - Bioethics Award
Ethical Issues in Partial Face Transplantation: Evaluation of Donor and Recipient Identity Changes
The major goal is to evaluate the degree to which a group of familiar reviewers recognize donors of facial transplantations performed by manipulating photographs of known subjects.

Sharpoint - Educational Grant
Microsurgery Skills Training
The major goal is to compare the different methodologies of microsurgery skills acquisition and evaluate stressors that may affect microsurgery performance in surgeons with variable levels of experience.